Pre_GI: BLASTP Hits

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Query: NC_009495:3502000:3510946 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 3510946, End: 3511680, Length: 735

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:3463736:348693434869343487668735Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-87321
NC_012563:3729817:375302037530203753754735Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-86318
NC_009699:3581376:360458036045803605314735Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-84312
NC_017297:3594000:360319636031963603666471Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein9e-63239
NC_004557:2552418:255532525553252556050726Clostridium tetani E88, complete genomeputative membrane-associated alkaline phosphatase4e-39161
NC_014410:2149886:215677721567772157466690Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,SNARE associated Golgi protein9e-33140
NC_015555:693461:707062707062707739678Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeSNARE associated Golgi protein-like protein1e-32140
NC_019970:2190695:220060122006012201278678Thermoanaerobacterium thermosaccharolyticum M0795, complete genomehypothetical protein4e-32138
NC_013967:827150:844055844055844780726Haloferax volcanii DS2 chromosome, complete genomeDedA family3e-1995.9
NC_017297:2796000:280701528070152807734720Clostridium botulinum F str. 230613 chromosome, complete genomeDedA family protein3e-1685.5
NC_012029:1604291:161339816133981614102705Halorubrum lacusprofundi ATCC 49239 chromosome 1, complete genomeSNARE associated Golgi protein6e-1684.3
NC_010516:2777205:279108927910892791808720Clostridium botulinum B1 str. Okra, complete genomeDedA family protein2e-1582.8
NC_010520:2807429:282162728216272822346720Clostridium botulinum A3 str. Loch Maree, complete genomeDedA family protein6e-1581.3
NC_010516:2777205:279038627903862791123738Clostridium botulinum B1 str. Okra, complete genomeDedA family protein3e-1479
NC_017297:2796000:280631228063122807049738Clostridium botulinum F str. 230613 chromosome, complete genomeDedA family protein4e-1478.2
NC_010520:3580000:358881835888183589030213Clostridium botulinum A3 str. Loch Maree, complete genomeputative integral membrane protein8e-1477.4
NC_010520:2807429:282092428209242821661738Clostridium botulinum A3 str. Loch Maree, complete genomeDedA family protein2e-1376.3
NC_008212:1759535:176638017663801767144765Haloquadratum walsbyi DSM 16790, complete genomehypothetical protein2e-1272.4
NC_018665:2563375:256901525690152569668654Exiguobacterium antarcticum B7 chromosome, complete genomeSNARE associated Golgi family protein3e-1272.4
NC_010556:2773396:277921927792192779872654Exiguobacterium sibiricum 255-15, complete genomeSNARE associated Golgi protein9e-1270.5
NC_013204:3491441:349643934964393497257819Eggerthella lenta DSM 2243, complete genomeSNARE associated Golgi protein5e-1168.2
NC_015602:1339067:135502213550221355630609Lactobacillus kefiranofaciens ZW3 chromosome, complete genomeintegral membrane protein3e-0962.4
NC_003888:3817000:381774538177453818494750Streptomyces coelicolor A3(2), complete genomeintegral membrane protein6e-0961.2
NC_015214:1700000:171706417170641717672609Lactobacillus acidophilus 30SC chromosome, complete genomehypothetical protein1e-0860.5
NC_014724:1731238:174829617482961748904609Lactobacillus amylovorus GRL 1112 chromosome, complete genomehypothetical protein1e-0860.5
NC_010080:1685280:170159317015931702201609Lactobacillus helveticus DPC 4571, complete genomehypothetical protein2e-0859.7
NC_008530:1551356:158414115841411584740600Lactobacillus gasseri ATCC 33323, complete genomehypothetical protein8e-0857.4
NC_021175:1291707:130703013070301307656627Streptococcus oligofermentans AS 1.3089, complete genomehypothetical protein9e-0857.4
NC_003888:1395319:139846313984631399239777Streptomyces coelicolor A3(2), complete genomeintegral membrane protein2e-0756.2
NC_005362:1651767:168836216883621688961600Lactobacillus johnsonii NCC 533, complete genomehypothetical protein2e-0756.2
NC_013504:1468227:149820214982021498801600Lactobacillus johnsonii FI9785 chromosome, complete genomehypothetical protein2e-0756.2
NC_018528:1681060:169850216985021699101600Lactobacillus helveticus R0052 chromosome, complete genomeintegral membrane protein8e-0754.3
NC_014976:627935:627935627935628561627Bacillus subtilis BSn5 chromosome, complete genomehypothetical protein1e-0653.5
UCMB5137:2054735:205947220594722060098627Bacillus atrophaeus UCMB-5137hypothetical protein2e-0653.1
NC_019940:1670262:1670262167026216725172256Thioflavicoccus mobilis 8321 chromosome, complete genomephosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase2e-0652.8
NC_014639:2169277:217073621707362171362627Bacillus atrophaeus 1942 chromosome, complete genomehypothetical protein3e-0652.4
CP002207:2169277:217073621707362171362627Bacillus atrophaeus 1942, complete genomehypothetical protein3e-0652.4
NC_009464:180335:190897190897191577681Uncultured methanogenic archaeon RC-I, complete genomehypothetical protein3e-0652.4