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Query: NC_009495:3502000:3510307 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 3510307, End: 3510951, Length: 645

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:3463736:348629534862953486939645Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein1e-70265
NC_017297:3594000:360255736025573603201645Clostridium botulinum F str. 230613 chromosome, complete genomeintegral membrane protein1e-70265
NC_009699:3581376:360394136039413604585645Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-70265
NC_012563:3729817:375238137523813753025645Clostridium botulinum A2 str. Kyoto, complete genomeintegral membrane protein TIGR019063e-70264
NC_010520:3580000:358817935881793588823645Clostridium botulinum A3 str. Loch Maree, complete genomeintegral membrane protein TIGR019062e-66252
NC_004557:2552418:255468325546832555321639Clostridium tetani E88, complete genomemembrane spanning protein4e-26117
NC_005945:1459357:146087214608721461558687Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-21102
NC_007530:1459412:146091814609181461604687Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-21102
NC_014393:3650957:365335536533553653984630Clostridium cellulovorans 743B chromosome, complete genomeintegral membrane protein TIGR019064e-21101
NC_021182:1473535:148854114885411489209669Clostridium pasteurianum BC1, complete genomeintegral membrane protein TIGR019062e-1995.9
NC_010723:3530000:353746035374603538140681Clostridium botulinum E3 str. Alaska E43, complete genomeintegral membrane protein7e-1373.9
NC_014334:769205:770640770640771263624Lactobacillus casei str. Zhang chromosome, complete genomehypothetical protein3e-1272
NC_008262:2498000:250201825020182502668651Clostridium perfringens SM101, complete genomeintegral membrane protein4e-1271.6
NC_013198:813830:818158818158818790633Lactobacillus rhamnosus GG, complete genomeconserved hypothetical protein (integral membrane protein by homology)4e-1271.2
NC_010999:880878:881660881660882283624Lactobacillus casei, complete genomePutative uncharacterized protein ylfI5e-1271.2
NC_008526:817628:819063819063819686624Lactobacillus casei ATCC 334, complete genomePredicted membrane protein5e-1271.2
NC_013199:811929:812706812706813338633Lactobacillus rhamnosus Lc 705, complete genomeconserved hypothetical protein (integral membrane protein by homology)2e-1169.3
NC_010674:3674739:368027836802783680958681Clostridium botulinum B str. Eklund 17B, complete genomeintegral membrane protein4e-1168.2
NC_012470:853561:856218856218856859642Streptococcus equi subsp. zooepidemicus, complete genomemembrane protein6e-1064.3
NC_016605:766836:771932771932772564633Pediococcus claussenii ATCC BAA-344 chromosome, complete genomehypothetical protein1e-0860.1
NC_011134:1222739:123839712383971239044648Streptococcus equi subsp. zooepidemicus str. MGCS10565, completehypothetical membrane spanning protein2e-0859.7
NC_014727:1537183:155327615532761553881606Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,membrane protein5e-0754.7
NC_010080:445398:448172448172448780609Lactobacillus helveticus DPC 4571, complete genomeputative membrane protein6e-0754.3
NC_018528:446610:452265452265452873609Lactobacillus helveticus R0052 chromosome, complete genomeMembrane protein2e-0652.4