Pre_GI: BLASTP Hits

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Query: NC_009495:3502000:3507221 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 3507221, End: 3507970, Length: 750

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:3359766:338031733803173381066750Clostridium botulinum A str. Hall chromosome, complete genomePP-loop family protein1e-141502
NC_009697:3463736:348320934832093483958750Clostridium botulinum A str. ATCC 19397 chromosome, completePP-loop family protein1e-141502
NC_017297:3594000:359947135994713600220750Clostridium botulinum F str. 230613 chromosome, complete genomePP-loop family protein2e-139494
NC_009699:3581376:360085536008553601604750Clostridium botulinum F str. Langeland chromosome, complete genomePP-loop family protein2e-139494
NC_012563:3729817:374929537492953750044750Clostridium botulinum A2 str. Kyoto, complete genomePP-loop family protein3e-139494
NC_010520:3580000:358509335850933585842750Clostridium botulinum A3 str. Loch Maree, complete genomePP-loop family protein6e-137486
NC_008593:2136759:214340821434082144145738Clostridium novyi NT, complete genomehypothetical protein1e-90332
NC_015425:2389400:239992923999292400630702Clostridium botulinum BKT015925 chromosome, complete genomePP-loop family protein4e-87320
NC_009495:183767:199073199073199795723Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein7e-52203
NC_014209:1363151:137674813767481377455708Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,PP-loop domain protein3e-45182
NC_013921:1344000:135699113569911357698708Thermoanaerobacter italicus Ab9 chromosome, complete genomePP-loop domain protein1e-44179
NC_010320:1805818:182159518215951822302708Thermoanaerobacter sp. X514 chromosome, complete genomePP-loop domain-containing protein3e-44178
NC_014538:1125000:113204111320411132748708Thermoanaerobacter sp. X513 chromosome, complete genomePP-loop domain-containing protein3e-44178
NC_010321:1361748:137499913749991375706708Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completePP-loop domain-containing protein3e-44178
NC_014964:1353939:136718913671891367896708Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completePP-loop domain-containing protein3e-44178
NC_015958:1465631:147908314790831479790708Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomePP-loop domain-containing protein2e-43176
NC_015381:4182194:418259541825954183584990Burkholderia gladioli BSR3 chromosome 1, complete sequencePP-loop family protein1e-30133
NC_008825:564392:586478586478587419942Methylibium petroleiphilum PM1, complete genomehypothetical protein2e-30132
NC_016589:2875000:2903444290344429044511008Burkholderia sp. YI23 chromosome 1, complete sequencePP-loop domain-containing protein1e-29130
NC_015731:25493:254932549326398906Nitrosomonas sp. Is79A3 chromosome, complete genometRNA 2-thiocytidine biosynthesis protein TtcA1e-29130
NC_005861:1027000:104063410406341041374741Candidatus Protochlamydia amoebophila UWE25, complete genomehypothetical protein3e-29129
NC_007951:4608560:4627865462786546288751011Burkholderia xenovorans LB400 chromosome 1, complete sequencehypothetical protein4e-29128
NC_008800:2298000:230832423083242309265942Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,C32 tRNA thiolase4e-29128
NC_018868:282738:299473299473300393921Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genomehypothetical protein3e-29128
NC_012917:2641000:265690226569022657837936Pectobacterium carotovorum subsp. carotovorum PC1, complete genomePP-loop domain protein5e-29127
CP002516:2580774:260536326053632606298936Escherichia coli KO11, complete genomePP-loop domain protein3e-28125
CP002185:1493280:149955214995521500487936Escherichia coli W, complete genomepredicted C32 tRNA thiolase3e-28125
NC_016902:2580774:260536326053632606298936Escherichia coli KO11FL chromosome, complete genomePP-loop domain-containing protein3e-28125
NC_010473:1493983:149843314984331499368936Escherichia coli str. K-12 substr. DH10B, complete genomeputative tRNA 2-thiocytidine (s(2)C32) synthase3e-28125
NC_000913:1404000:140903714090371409972936Escherichia coli K12, complete genomepredicted C32 tRNA thiolase3e-28125
AC_000091:1407693:141272714127271413662936Escherichia coli W3110 DNA, complete genomepredicted C32 tRNA thiolase3e-28125
NC_012759:1296000:130109613010961302031936Escherichia coli BW2952 chromosome, complete genomeC32 tRNA thiolase3e-28125
NC_009648:1541699:154169915416991542634936Klebsiella pneumoniae subsp. pneumoniae MGH 78578, complete genomeC32 tRNA thiolase3e-28125
NC_011415:1472500:147444114744411475376936Escherichia coli SE11 chromosome, complete genomeC32 tRNA thiolase2e-28125
NC_012947:2366000:238526623852662386201936Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeC32 tRNA thiolase2e-28125
NC_012967:1403733:140818314081831409118936Escherichia coli B str. REL606 chromosome, complete genomeC32 tRNA thiolase2e-28125
NC_013716:1756545:176912717691271770062936Citrobacter rodentium ICC168, complete genometRNA 2-thiocytidine biosynthesis protein ttcA6e-28124
NC_011149:1429523:145488714548871455822936Salmonella enterica subsp. enterica serovar Agona str. SL483,YdaO6e-28124
NC_015761:1630000:163960516396051640540936Salmonella bongori NCTC 12419, complete genomehypothetical protein5e-28124
NC_014121:1848971:185572818557281856663936Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeC32 tRNA thiolase5e-28124
NC_011294:1465500:146842814684281469363936Salmonella enterica subsp. enterica serovar Enteritidis strC32 tRNA thiolase5e-28124
NC_020063:2449554:246555224655522466487936Enterobacteriaceae bacterium strain FGI 57, complete genomeputative ATPase of the PP-loop superfamily implicated in cell cycle control4e-28124
NC_017379:1233482:123836712383671239128762Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein2e-26119
NC_019940:1309359:132790513279051328654750Thioflavicoccus mobilis 8321 chromosome, complete genomeATPase of the PP-loop superfamily implicated in cell cycle control4e-26118
NC_017378:1175639:118052011805201181281762Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein7e-26117
NC_014315:1668366:168172916817291682613885Nitrosococcus watsoni C-113 chromosome, complete genomePP-loop domain-containing protein2e-25116
NC_009092:2282437:230676723067672307720954Shewanella loihica PV-4, complete genomePP-loop domain protein3e-25115
NC_011770:4542183:454432145443214545145825Pseudomonas aeruginosa LESB58, complete genomeputative ATPase of the PP-loop superfamily9e-25114
NC_008463:4342119:434425743442574345081825Pseudomonas aeruginosa UCBPP-PA14, complete genomeputative ATPase of the PP-loop superfamily9e-25114
NC_018012:4184500:418915041891504189950801Thiocystis violascens DSM 198 chromosome, complete genomeputative ATPase of the PP-loop superfamily implicated in cell cycle control9e-24110
NC_015737:1385585:1391393139139313925441152Clostridium sp. SY8519, complete genomehypothetical protein8e-23107
NC_008599:1489868:149288114928811493633753Campylobacter fetus subsp. fetus 82-40, complete genomePP-loop family protein3e-22105
NC_008209:1385094:138509413850941386023930Roseobacter denitrificans OCh 114, complete genomehypothetical protein2e-21103
NC_015499:1403447:141819014181901418915726Thermodesulfobium narugense DSM 14796 chromosome, complete genomePP-loop domain protein4e-21101
NC_015931:1653604:1653604165360416546471044Pyrolobus fumarii 1A, complete genomePP-loop domain containing protein2e-2099.4
NC_008942:960306:963510963510964412903Methanocorpusculum labreanum Z, complete genomehypothetical protein2e-1996.3
NC_016051:1429800:145592514559251456902978Thermococcus sp. AM4 chromosome, complete genomePP-loop superfamily ATPase7e-1994.4
NC_013410:1651000:165494716549471655708762Fibrobacter succinogenes subsp. succinogenes S85 chromosome,PP-loop domain-containing protein8e-1994
NC_015958:84270:949399493995832894Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genometRNA methyl transferase-like protein6e-1891.3
NC_014538:73272:788567885679749894Thermoanaerobacter sp. X513 chromosome, complete genomeATPase1e-1790.1
NC_010320:1769486:178549117854911786384894Thermoanaerobacter sp. X514 chromosome, complete genomePP-loop domain-containing protein1e-1790.1
NC_011529:1554500:155663715566371557608972Thermococcus onnurineus NA1, complete genomeATPase4e-1788.2
NC_014205:760428:763414763414764409996Staphylothermus hellenicus DSM 12710 chromosome, complete genomePP-loop domain protein2e-1582.8
NC_013173:1671288:167528116752811676219939Desulfomicrobium baculatum DSM 4028, complete genomePP-loop domain protein2e-1582.4
NC_015577:3244857:324485732448573245621765Treponema azotonutricium ZAS-9 chromosome, complete genomeATPase, PP-loop superfamily3e-1582.4
NC_014844:2638994:264204526420452642974930Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomePP-loop domain-containing protein4e-1581.6
NC_015562:1816000:183104018310401831951912Methanotorris igneus Kol 5 chromosome, complete genometRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase2e-1479.7
NC_013407:1177731:118883811888381189755918Methanocaldococcus vulcanius M7, complete genomePP-loop domain protein4e-1478.6
NC_015948:2421933:243531324353132436308996Haloarcula hispanica ATCC 33960 chromosome chromosome I, completePP-loop domain-containing protein5e-1478.2
NC_009012:2661795:2683143268314326845551413Clostridium thermocellum ATCC 27405, complete genometRNA(Ile)-lysidine synthetase8e-1477.4
NC_009515:510121:531360531360532277918Methanobrevibacter smithii ATCC 35061, complete genomePP family ATPase2e-1376.3
NC_009776:617532:6363546363546375051152Ignicoccus hospitalis KIN4/I, complete genomePP-loop domain protein2e-1375.9
NC_015865:1260461:128320912832091284117909Thermococcus sp. 4557 chromosome, complete genomeATPase4e-1375.1
NC_013202:149473:171414171414172412999Halomicrobium mukohataei DSM 12286, complete genomePP-loop domain protein6e-1374.3
NC_014483:39729:5869858698601461449Paenibacillus polymyxa E681 chromosome, complete genometRNA(Ile)-lysidine synthase1e-1273.9
NC_016641:1639356:1657391165739116588391449Paenibacillus terrae HPL-003 chromosome, complete genometRNA(Ile)-lysidine synthase1e-1170.1
NC_005791:1334880:133557813355781336522945Methanococcus maripaludis S2, complete genomehypothetical protein2e-1169.7
NC_015847:1418036:141990114199011420836936Methanococcus maripaludis XI chromosome, complete genomePP-loop domain-containing protein2e-1169.3
NC_017095:1333810:133532013353201336231912Fervidobacterium pennivorans DSM 9078 chromosome, complete genomehypothetical protein2e-1169.3
NC_005213:202400:255499255499256305807Nanoarchaeum equitans Kin4-M, complete genomehypothetical protein2e-1169.3
NC_015931:1537960:154828615482861549212927Pyrolobus fumarii 1A, complete genomePP-loop domain containing protein4e-1168.6
NC_018704:81733:8173381733831361404Amphibacillus xylanus NBRC 15112, complete genometRNA(Ile)-lysidine synthase4e-1168.6
NC_014374:344500:349736349736350725990Acidilobus saccharovorans 345-15 chromosome, complete genomehypothetical protein4e-1168.6
NC_009975:1203372:122850712285071229481975Methanococcus maripaludis C6, complete genomePP-loop domain protein6e-1168.2
NC_013849:933913:949846949846950718873Ferroglobus placidus DSM 10642 chromosome, complete genomePP-loop domain protein1e-1067
NC_009975:1203372:122556212255621226497936Methanococcus maripaludis C6, complete genomePP-loop domain protein8e-1064.3
NC_014758:1489761:1510126151012615113881263Calditerrivibrio nitroreducens DSM 19672 chromosome, completetRNA(ile)-lysidine synthetase1e-0963.9
NC_009634:714715:715694715694716620927Methanococcus vannielii SB chromosome, complete genomePP-loop domain-containing protein1e-0963.5
NC_015425:163000:1656221656221670251404Clostridium botulinum BKT015925 chromosome, complete genomecell cycle protein MesJ2e-0963.2
NC_009637:602079:603943603943604878936Methanococcus maripaludis C7 chromosome, complete genomePP-loop domain-containing protein2e-0963.2
NC_003869:2267627:2283780228378022851831404Thermoanaerobacter tengcongensis MB4, complete genomepredicted ATPase of the PP-loop superfamily implicated in cell cycle control6e-0961.2
NC_009635:800000:822629822629823564936Methanococcus aeolicus Nankai-3 chromosome, complete genomePP-loop domain-containing protein8e-0960.8
NC_000909:404961:4270914270914281041014Methanocaldococcus jannaschii DSM 2661, complete genomehypothetical protein1e-0860.5
NC_017285:913000:930916930916931875960Chlamydophila pneumoniae LPCoLN chromosome, complete genometRNA(Ile)-lysidine synthetase1e-0860.5
NC_013887:1668913:1691825169182516928351011Methanocaldococcus sp. FS406-22 chromosome, complete genomePP-loop domain protein1e-0860.5
NC_006055:769418:7837767837767849721197Mesoplasma florum L1, complete genomelysidine synthetase1e-0860.1
NC_017208:64500:6731767317686091293Bacillus thuringiensis serovar chinensis CT-43 chromosome, completecell cycle protein MesJ1e-0860.1
NC_008710:819389:8323068323068336251320Borrelia turicatae 91E135, complete genometRNA(Ile)-lysidine synthetase TilS2e-0859.7
NC_015318:1455444:145731014573101458278969Hippea maritima DSM 10411 chromosome, complete genometRNA(Ile)-lysidine synthase2e-0859.7
NC_002754:513790:514553514553515524972Sulfolobus solfataricus P2, complete genomehypothetical protein3e-0858.9
NC_004557:162670:1626701626701640731404Clostridium tetani E88, complete genomecell cycle protein mesJ5e-0858.5
NC_004757:1089057:1109547110954711109231377Nitrosomonas europaea ATCC 19718, complete genomehypothetical protein4e-0858.5
NC_009495:3735703:3769960376996037713661407Clostridium botulinum A str. ATCC 3502 chromosome, complete genometRNA(Ile)-lysidine synthetase4e-0858.5
NC_009698:3609881:3643059364305936444651407Clostridium botulinum A str. Hall chromosome, complete genometRNA(Ile)-lysidine synthetase4e-0858.5
NC_009089:4140764:4161747416174741631351389Clostridium difficile 630, complete genomeputative ATPase4e-0858.5
NC_013316:4018451:4040068404006840414561389Clostridium difficile R20291, complete genomeputative ATPase4e-0858.5
NC_007498:1148249:1168260116826011696361377Pelobacter carbinolicus DSM 2380, complete genomecell cycle protein4e-0858.5
NC_010723:173280:1812001812001826061407Clostridium botulinum E3 str. Alaska E43, complete genometRNA(Ile)-lysidine synthase5e-0858.2
NC_009699:3839575:3872747387274738741531407Clostridium botulinum F str. Langeland chromosome, complete genometRNA(Ile)-lysidine synthetase7e-0857.8
NC_012588:1419318:143754814375481438519972Sulfolobus islandicus M.14.25 chromosome, complete genomePP-loop domain-containing protein6e-0857.8
NC_012622:1395601:141489314148931415864972Sulfolobus islandicus Y.G.57.14 chromosome, complete genomePP-loop domain-containing protein6e-0857.8
NC_012623:1141951:114222811422281143199972Sulfolobus islandicus Y.N.15.51 chromosome, complete genomePP-loop domain-containing protein6e-0857.8
NC_012632:1543735:156196515619651562936972Sulfolobus islandicus M.16.27 chromosome, complete genomePP-loop domain-containing protein6e-0857.8
NC_003106:1457802:145808914580891459057969Sulfolobus tokodaii str. 7, complete genomehypothetical veg136 protein3e-0755.8
NC_009635:800000:8249398249398259431005Methanococcus aeolicus Nankai-3 chromosome, complete genomePP-loop domain-containing protein3e-0755.5
NC_015958:2361551:2377798237779823791741377Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genometRNA(Ile)-lysidine synthase4e-0755.5
NC_008593:153014:1555461555461569401395Clostridium novyi NT, complete genomeCell cycle protein MesJ, putative4e-0755.1
NC_018664:2459994:2484668248466824860501383Clostridium acidurici 9a chromosome, complete genometRNA(Ile)-lysidine synthase5e-0754.7
NC_014328:4471995:4497934449793444993401407Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative tRNA(Ile)-lysidine synthase9e-0754.3
NC_013939:1023443:1026346102634610276051260Deferribacter desulfuricans SSM1, complete genomecell cycle protein MesJ1e-0653.5
NC_010320:819326:8235828235828249581377Thermoanaerobacter sp. X514 chromosome, complete genometRNA(Ile)-lysidine synthetase6e-0651.2