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Query: NC_009495:280000:300969 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 300969, End: 301346, Length: 378

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:275919:293969293969294346378Clostridium botulinum A str. ATCC 19397 chromosome, completecytidine/deoxycytidylate deaminase family protein7e-62235
NC_012658:3678000:367889236788923679296405Clostridium botulinum Ba4 str. 657 chromosome, complete genomecytidine deaminase1e-1995.1
NC_010520:3674883:368435336843533684757405Clostridium botulinum A3 str. Loch Maree, complete genomecytidine/deoxycytidylate deaminase family protein1e-1995.1
NC_013721:533048:545245545245545679435Gardnerella vaginalis 409-05, complete genomecytidine/deoxycytidylate deaminase family protein6e-1269.3
NC_013721:820852:831233831233831667435Gardnerella vaginalis 409-05, complete genomecytidine/deoxycytidylate deaminase family protein6e-1269.3
NC_014246:1991093:200201820020182002563546Mobiluncus curtisii ATCC 43063 chromosome, complete genomecytidine deaminase1e-1065.1
NC_016751:1227495:123816512381651238590426Marinitoga piezophila KA3 chromosome, complete genomecytidine deaminase7e-1062.8
NC_015518:685885:708349708349708744396Acidianus hospitalis W1 chromosome, complete genomecytidine deaminase6e-0959.3
NC_016070:1657500:166133116613311661723393Thermoproteus tenax Kra 1, complete genomeCytidine deaminase6e-0856.2
NC_011661:1332309:134439213443921344787396Dictyoglomus turgidum DSM 6724, complete genomecytidine deaminase4e-0753.5
NC_007503:1383255:138913313891331389531399Carboxydothermus hydrogenoformans Z-2901, complete genomecytidine deaminase5e-0753.1
NC_009073:1:666166617044384Pyrobaculum calidifontis JCM 11548, complete genomecytidine deaminase1e-0651.6
NC_016885:2091918:212987721298772130260384Pyrobaculum oguniense TE7 chromosome, complete genomecytidine deaminase3e-0650.8