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Query: NC_009495:280000:293557 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 293557, End: 294531, Length: 975

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:275919:286557286557287531975Clostridium botulinum A str. ATCC 19397 chromosome, complete2-keto-3-deoxygluconate permease1e-120432
NC_010321:1703000:171124317112431712208966Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, complete2-keto-3-deoxygluconate permease1e-56220
NC_014964:1695000:170345617034561704421966Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, complete2-keto-3-deoxygluconate permease1e-56220
NC_019978:1182056:119232511923251193296972Halobacteroides halobius DSM 5150, complete genome2-keto-3-deoxygluconate permease2e-54213
NC_009328:3322802:3341237334123733422681032Geobacillus thermodenitrificans NG80-2 chromosome, complete genome2-keto-3-deoxygluconate permease6e-50198
NC_007503:1111457:112025011202501121212963Carboxydothermus hydrogenoformans Z-2901, complete genome2-keto-3-deoxygluconate permease9e-42171
NC_013406:347995:364518364518365501984Paenibacillus sp. Y412MC10 chromosome, complete genome2-keto-3-deoxygluconate permease3e-41169
NC_020302:85821:1335821335821346251044Corynebacterium halotolerans YIM 70093 = DSM 44683, complete2-keto-3-deoxygluconate permease8e-41167
NC_006270:3627974:365184436518443652827984Bacillus licheniformis ATCC 14580, complete genome2-keto-3-deoxygluconate permease1e-33144
NC_006322:3628143:365201336520133652999987Bacillus licheniformis ATCC 14580, complete genome2-keto-3-deoxygluconate permease1e-33144
NC_015663:2807574:281868828186882819686999Enterobacter aerogenes KCTC 2190 chromosome, complete genome2-keto-3-deoxygluconate permease1e-32140
NC_016860:4024000:403945840394584040423966Salmonella enterica subsp. enterica serovar Typhimurium str2-keto-3-deoxygluconate permease2e-32139
NC_011001:163813:1782701782701792891020Burkholderia cenocepacia J2315 chromosome 2, complete sequence2-keto-3-deoxygluconate permease1e-30134