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Query: NC_009495:280000:289562 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 289562, End: 290221, Length: 660

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:275919:282562282562283221660Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-130464
NC_009633:2137999:214002721400272140611585Alkaliphilus metalliredigens QYMF chromosome, complete genomecupin1e-61236
NC_009012:2953638:296956229695622970170609Clostridium thermocellum ATCC 27405, complete genomeCupin 2, conserved barrel7e-61233
NC_000964:2702376:271415927141592714719561Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein1e-60232
NC_019896:1483073:151112415111241511684561Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completehypothetical protein2e-60231
NC_014976:684000:698796698796699356561Bacillus subtilis BSn5 chromosome, complete genomeputative dioxygenase2e-59228
NC_016641:2618587:262747426274742628007534Paenibacillus terrae HPL-003 chromosome, complete genomecupin4e-59227
NC_019842:484933:532745532745533278534Bacillus amyloliquefaciens subsp. plantarum AS43.3 chromosome,hypothetical protein4e-59227
NC_009725:496443:540979540979541512534Bacillus amyloliquefaciens FZB42, complete genomeYrkC7e-59226
NC_015690:1109335:111838011183801119114735Paenibacillus mucilaginosus KNP414 chromosome, complete genomeCupin 2 barrel domain-containing protein8e-59226
NC_014551:483773:505864505864506397534Bacillus amyloliquefaciens DSM 7, complete genomedioxygenase; cupin family2e-58225
NC_017188:461177:493341493341493874534Bacillus amyloliquefaciens TA208 chromosome, complete genomedioxygenase; cupin family protein2e-58225
NC_017191:467207:499363499363499896534Bacillus amyloliquefaciens XH7 chromosome, complete genomedioxygenase; cupin family2e-58225
NC_013406:781308:798376798376798921546Paenibacillus sp. Y412MC10 chromosome, complete genomeCupin 2 conserved barrel domain-containing protein2e-50198
NC_006582:883922:898007898007898519513Bacillus clausii KSM-K16, complete genomehypothetical protein5e-50197
NC_004193:375416:398220398220399122903Oceanobacillus iheyensis HTE831, complete genomehypothetical protein6e-49193
NC_016052:2335648:235546023554602355882423Tetragenococcus halophilus NBRC 12172, complete genomehypothetical protein4e-42171
NC_007759:1169547:118048611804861180995510Syntrophus aciditrophicus SB, complete genomemannose-6-phosphate isomerase3e-42171
NC_013169:612456:612993612993613415423Kytococcus sedentarius DSM 20547, complete genomemannose-6-phosphate isomerase3e-38158
NC_009482:2109270:212250321225032123018516Synechococcus sp. RCC307 chromosome, complete genomehypothetical protein3e-38158
NC_007164:822000:822014822014822490477Corynebacterium jeikeium K411, complete genomehypothetical protein1e-33143
NC_019940:389979:410808410808411194387Thioflavicoccus mobilis 8321 chromosome, complete genomemannose-6-phosphate isomerase6e-30130
NC_015671:255808:285289285289285717429Cellvibrio gilvus ATCC 13127 chromosome, complete genomeCupin 2 barrel domain-containing protein5e-1787.8