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Query: NC_009495:2056546:2075159 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 2075159, End: 2075803, Length: 645

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:1985404:200401720040172004661645Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein9e-96349
NC_009697:1985187:200380020038002004444645Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein9e-96349
NC_012563:2203037:222165022216502222294645Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein9e-96349
NC_009699:2116500:213341221334122134056645Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein3e-95347
NC_017297:2114222:213351621335162134160645Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein3e-95347
NC_010516:2064027:208334420833442083988645Clostridium botulinum B1 str. Okra, complete genomehypothetical protein3e-95347
NC_010520:2171584:219285221928522193496645Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein1e-93342
NC_010080:1685280:170159317015931702201609Lactobacillus helveticus DPC 4571, complete genomehypothetical protein3e-0755.5
NC_018528:1681060:169850216985021699101600Lactobacillus helveticus R0052 chromosome, complete genomeintegral membrane protein1e-0653.5
NC_015602:1339067:135502213550221355630609Lactobacillus kefiranofaciens ZW3 chromosome, complete genomeintegral membrane protein6e-0650.8