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Query: NC_009495:2056546:2072329 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 2072329, End: 2073180, Length: 852

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:1985404:200118720011872002038852Clostridium botulinum A str. Hall chromosome, complete genometungstate ABC transporter tungstate-binding protein1e-145515
NC_009697:1985187:200097020009702001821852Clostridium botulinum A str. ATCC 19397 chromosome, completetungstate ABC transporter tungstate-binding protein1e-145515
NC_012563:2203037:221882022188202219671852Clostridium botulinum A2 str. Kyoto, complete genometungstate ABC transporter, tungstate-binding protein1e-145515
NC_010516:2064027:208051220805122081363852Clostridium botulinum B1 str. Okra, complete genometungstate ABC transporter, tungstate-binding protein7e-144509
NC_017297:2114222:213068421306842131535852Clostridium botulinum F str. 230613 chromosome, complete genometungstate ABC transporter tungstate-binding protein3e-143507
NC_009699:2116500:213058021305802131431852Clostridium botulinum F str. Langeland chromosome, complete genometungstate ABC transporter tungstate-binding protein3e-143507
NC_010520:2171584:219002321900232190874852Clostridium botulinum A3 str. Loch Maree, complete genometungstate ABC transporter, tungstate-binding protein3e-143507
NC_018664:3073022:307302230730223073915894Clostridium acidurici 9a chromosome, complete genomefamily 1 extracellular solute-binding protein6e-85313
NC_009633:1058000:106943010694301070293864Alkaliphilus metalliredigens QYMF chromosome, complete genomeextracellular solute-binding protein9e-75280
NC_009952:592000:625528625528626358831Dinoroseobacter shibae DFL 12, complete genomebasic organic compound ABC-transporter9e-58223
NC_017082:5925357:592651859265185927351834Bradyrhizobium sp. S23321, complete genomehypothetical protein3e-54211
NC_014972:2371647:239875123987512399641891Desulfobulbus propionicus DSM 2032 chromosome, complete genomehypothetical protein5e-50197
NC_010718:464405:466470466470467291822Natranaerobius thermophilus JW/NM-WN-LF, complete genomemolybdate-binding protein8e-47187
NC_008701:37219:418614186142790930Pyrobaculum islandicum DSM 4184, complete genomebinding protein, putative3e-46185
NC_002163:1471517:147228214722821473091810Campylobacter jejuni subsp. jejuni NCTC 11168, complete genomeputative periplasmic protein3e-45182
NC_015931:857327:875898875898876797900Pyrolobus fumarii 1A, complete genomefamily 1 extracellular solute-binding protein7e-41167
NC_015680:369777:3745793745793756131035Pyrococcus yayanosii CH1 chromosome, complete genomeABC transporter tungsten-binding protein1e-38160