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Query: NC_009495:1516000:1525724 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Start: 1525724, End: 1526728, Length: 1005

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010520:1586000:1598124159812415991581035Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein0668
NC_015707:1911431:1918950191895019199661017Thermotoga thermarum DSM 5069 chromosome, complete genomehypothetical protein3e-78292
NC_015953:3227000:3227066322706632281181053Streptomyces sp. SirexAA-E chromosome, complete genomehypothetical protein3e-60232
NC_006361:792904:7929047929047939261023Nocardia farcinica IFM 10152, complete genomehypothetical protein1e-58227
NC_016109:1775259:1775259177525917763291071Kitasatospora setae KM-6054, complete genomehypothetical protein2e-58226
NC_014815:1490957:151042115104211511401981Micromonospora sp. L5 chromosome, complete genomehypothetical protein1e-55216
NC_014830:3156873:3158150315815031591961047Intrasporangium calvum DSM 43043 chromosome, complete genomeglycoside hydrolase family 2 sugar binding protein4e-44178
NC_008260:2021162:2038399203839920394331035Alcanivorax borkumensis SK2, complete genomehypothetical protein7e-22104