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Query: NC_009494:775676:801075 Legionella pneumophila str. Corby chromosome, complete genome

Start: 801075, End: 801293, Length: 219

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Legionella pneumophila str. Corby is a human isolate. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014125:766576:787114787114787332219Legionella pneumophila 2300/99 Alcoy chromosome, complete genomemultidrug efflux protein4e-36149
NC_006368:750356:778084778084778434351Legionella pneumophila str. Paris, complete genomehypothetical protein6e-35145
NC_006369:734080:763740763740764090351Legionella pneumophila str. Lens, complete genomehypothetical protein2e-34144
NC_011901:2466360:247126724712672471692426Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completehypothetical protein6e-1889.4
NC_007484:2045500:2046956204695620495052550Nitrosococcus oceani ATCC 19707, complete genomehypothetical protein3e-1477.4
NC_008702:3375027:337684833768483377219372Azoarcus sp. BH72, complete genomeconserved hypothetical protein3e-1373.6
NC_014221:2943950:2953689295368929568863198Truepera radiovictrix DSM 17093 chromosome, complete genomeprotein of unknown function DUF5595e-1269.7
NC_014313:3617910:370237024091390Hyphomicrobium denitrificans ATCC 51888 chromosome, completeprotein of unknown function DUF5591e-1168.2
NC_019904:3072241:308520730852073085575369Echinicola vietnamensis DSM 17526 chromosome, complete genomehypothetical protein7e-1062.8
NC_020156:49666:705407054070791252Nonlabens dokdonensis DSW-6, complete genometype I site-specific deoxyribonuclease, HsdR family1e-0962
NC_008245:529378:547003547003547389387Francisella tularensis subsp. tularensis FSC 198, complete genomehypothetical protein3e-0960.5
NC_006570:529426:547051547051547437387Francisella tularensis subsp. tularensis Schu 4, complete genomehypothetical protein3e-0960.5
NC_016933:608889:622980622980623366387Francisella tularensis TIGB03 chromosome, complete genomeDNA methylase putative3e-0960.5
NC_016937:529459:547073547073547459387Francisella tularensis subsp. tularensis TI0902 chromosome,DNA methylase putative3e-0960.5
NC_008369:939356:952207952207952593387Francisella tularensis subsp. holarctica OSU18, complete genomehypothetical protein3e-0960.5
NC_009749:937412:950264950264950650387Francisella tularensis subsp. holarctica FTA, complete genomehypothetical protein3e-0960.5
NC_007880:935670:948522948522948908387Francisella tularensis subsp. holarctica, complete genomehypothetical protein3e-0960.5
NC_009257:963536:966722966722967108387Francisella tularensis subsp. tularensis WY96-3418 chromosome,hypothetical protein3e-0960.5
NC_008571:365047:3828973828973860373141Gramella forsetii KT0803, complete genome5-methyltetrahydrofolate:homocysteine methyltran sferase-cobalamin binding domain3e-0960.5
NC_015696:285456:296447296447296827381Francisella sp. TX077308 chromosome, complete genomeDNA methylase1e-0858.9
NC_002939:1480474:149751214975121498039528Geobacter sulfurreducens PCA, complete genomehypothetical protein4e-0856.6
NC_015633:461143:485740485740486096357Vibrio anguillarum 775 chromosome chromosome I, complete sequencehypothetical protein5e-0753.1
NC_019960:1362370:136185313618531362383531Prevotella dentalis DSM 3688 chromosome 1, complete sequencehypothetical protein2e-0651.2