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Query: NC_009494:775676:777751 Legionella pneumophila str. Corby chromosome, complete genome

Start: 777751, End: 779325, Length: 1575

Host Lineage: Legionella pneumophila; Legionella; Legionellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Legionella pneumophila str. Corby is a human isolate. Causes Legionnaire's disease. This organism is a non-marine bacterium usually found growing inside other organisms such as protozoans in aquatic environments. They can also be found in soil, freshwater, and in biofilms. The first outbreak of Legionnaire's disease occurred in 1976 at an American Legion convention and the resulting pneumonia-like disease resulted in 34 deaths. The cause of the disease was traced to Legionella bacteria. Once the bacteria are brought into the lungs they make contact with alveolar macrophages and are internalized where they can cause severe respiratory distress. Internalization occurs through specialized vacuoles (replicative phagosomes) that allow the bacteria to grow and replicate prior to escape from the macrophage. Formation of the replicative phagosome, which requires reprogramming of the normal phagosome maturation pathway, requires a type IV secretion system called the Dot/Icm system. This type IV system is closely related to the conjugative system of plasmid ColIb-P9, and is involved in the secretion of numerous protein components that aid in formation of the replicative phagosome. Other virulence determinants include a set of multidrug transporters and other efflux pumps for toxic compounds that may allow the organism to persist in its habitat, a set of LPS phase variable genes that enhance immune evasion, and a type II secretion system for transport of hydrolases.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014125:766576:7686517686517702251575Legionella pneumophila 2300/99 Alcoy chromosome, complete genomehypothetical protein01072
NC_006369:734080:7356057356057371791575Legionella pneumophila str. Lens, complete genomehypothetical protein01023
NC_002942:675829:6805946805946821681575Legionella pneumophila subsp. pneumophila str. Philadelphia 1,hypothetical protein01019
NC_006368:750356:7503567503567514951140Legionella pneumophila str. Paris, complete genomehypothetical protein0768
NC_006368:750356:751592751592751930339Legionella pneumophila str. Paris, complete genomehypothetical protein2e-56220