Pre_GI: BLASTP Hits

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Query: NC_009378:62215:88151 Yersinia pestis Pestoides F plasmid MT, complete sequence

Start: 88151, End: 88696, Length: 546

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009998:62000:495049505387438Shewanella baltica OS195 plasmid pS19501, complete sequencetype-F conjugative transfer system pilin assembly thiol-disulfide isomerase TrbB1e-1479.3
NC_007298:2856104:285610428561042856970867Dechloromonas aromatica RCB, complete genomehypothetical protein1e-0653.1
NC_015422:3493396:349621034962103497085876Alicycliphilus denitrificans K601 chromosome, complete genomeTraF-like protein2e-0651.6