Pre_GI: BLASTP Hits

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Query: NC_009378:62215:70203 Yersinia pestis Pestoides F plasmid MT, complete sequence

Start: 70203, End: 70589, Length: 387

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: Atypical strain isolated from the former Soviet Union, USSR. This strain lacks a plasminogen activator and is virulent by the aerosol route. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008118:56777:647656476565151387Yersinia pestis Nepal516 plasmid pMT, complete sequencehypothetical protein3e-69259
NC_008120:62000:669876698767373387Yersinia pestis Antiqua plasmid pMT, complete sequencehypothetical protein3e-69259
NC_005815:61148:710957109571481387Yersinia pestis biovar Microtus str. 91001 plasmid pMT1, completehypothetical protein3e-69259
NC_004838:51013:841048410484490387Yersinia pestis KIM plasmid pMT-1, complete sequencehypothetical protein3e-69259
NC_003134:64672:883208832088706387Yersinia pestis CO92 plasmid pMT1, complete sequencehypothetical protein3e-69259