Pre_GI: BLASTN Hits

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Query: NC_009089:1329826 Clostridium difficile 630, complete genome

Start: 1329826, End: 1352153, Length: 22328

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013316:11861561186156120513718982Clostridium difficile R20291, complete genome018460BLASTN svgBLASTP svg
NC_012563:3416509*3416509343524718739Clostridium botulinum A2 str. Kyoto, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_010516:3234791*3234791325832823538Clostridium botulinum B1 str. Okra, complete genome2e-1695.6BLASTN svgBLASTP svg
NC_016012:396910*39691041471617807Candidatus Arthromitus sp. SFB-rat-Yit, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_015687:13773671377367140027722911Clostridium acetobutylicum DSM 1731 chromosome, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_003030:13757641375764139779422031Clostridium acetobutylicum ATCC 824, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_021182:2160580*2160580218559925020Clostridium pasteurianum BC1, complete genome4e-0867.9BLASTN svgBLASTP svg
NC_003454:63500*6350010726843769Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete4e-0867.9BLASTN svgBLASTP svg
NC_014328:794000*79400081614922150Clostridium ljungdahlii ATCC 49587 chromosome, complete genome7e-0763.9BLASTN svgBLASTP svg