Pre_GI: BLASTN Hits

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Query: NC_009089:1283000 Clostridium difficile 630, complete genome

Start: 1283000, End: 1324218, Length: 41219

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_013316:2033906*2033906211557281667Clostridium difficile R20291, complete genome01134BLASTN svgBLASTP svg
NC_015385:2050648*2050648208291832271Treponema succinifaciens DSM 2489 chromosome, complete genome0684BLASTN svgBLASTP svg
NC_012781:700226*70022673549235267Eubacterium rectale ATCC 33656, complete genome1e-28137BLASTN svgBLASTP svg
NC_012781:2552723*2552723258830435582Eubacterium rectale ATCC 33656, complete genome1e-28137BLASTN svgBLASTP svg
NC_018867:10238*102387208361846Dehalobacter sp. CF chromosome, complete genome4e-25125BLASTN svgBLASTP svg
NC_013316:40959054095905412999634092Clostridium difficile R20291, complete genome2e-23119BLASTN svgBLASTP svg
NC_009089:370555*37055539409923545Clostridium difficile 630, complete genome9e-20107BLASTN svgBLASTP svg
NC_004668:2198027*2198027227009972073Enterococcus faecalis V583, complete genome4e-19105BLASTN svgBLASTP svg
NC_012781:33156143315614335472839115Eubacterium rectale ATCC 33656, complete genome1e-18103BLASTN svgBLASTP svg
NC_013316:371953*37195339532823376Clostridium difficile R20291, complete genome2e-1799.6BLASTN svgBLASTP svg
NC_002758:43446243446245281818357Staphylococcus aureus subsp. aureus Mu50, complete genome8e-1487.7BLASTN svgBLASTP svg
NC_009089:42807542807546635638282Clostridium difficile 630, complete genome2e-1179.8BLASTN svgBLASTP svg
NC_008023:1070986*1070986111333242347Streptococcus pyogenes MGAS2096, complete genome2e-1179.8BLASTN svgBLASTP svg
NC_018720:993869*993869102159927731Bifidobacterium asteroides PRL2011 chromosome, complete genome5e-0971.9BLASTN svgBLASTP svg
NC_021175:15976131597613162110823496Streptococcus oligofermentans AS 1.3089, complete genome2e-0869.9BLASTN svgBLASTP svg
NC_013895:13328321332832138009947268Clostridiales genomosp. BVAB3 str. UPII9-5 chromosome, complete2e-0869.9BLASTN svgBLASTP svg
NC_013798:17441181744118176331619199Streptococcus gallolyticus UCN34, complete genome1e-0663.9BLASTN svgBLASTP svg
NC_009089:21500622150062217431124250Clostridium difficile 630, complete genome1e-0663.9BLASTN svgBLASTP svg