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Query: NC_009089:873295:874523 Clostridium difficile 630, complete genome

Start: 874523, End: 874654, Length: 132

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:796313:800583800583800702120Clostridium difficile CD196 chromosome, complete genome3e-1167.4
NC_013316:796895:798123798123798242120Clostridium difficile R20291, complete genome3e-1167.4
NC_015164:3431279:344942134494213449996576Bacteroides salanitronis DSM 18170 chromosome, complete genomeacetyltransferase1e-0858.5
NC_014976:2175667:219220721922072192761555Bacillus subtilis BSn5 chromosome, complete genomemaltose O-acetyltransferase2e-0754.3
NC_019896:17873:192601926019814555Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completeMaltose O-acetyltransferase2e-0754.3
NC_009831:3583856:359683835968383597374537Shewanella sediminis HAW-EB3, complete genomeAcetyltransferase (isoleucine patch superfamily)-like protein6e-0753.1
NC_021182:3525523:353388535338853534514630Clostridium pasteurianum BC1, complete genomephosphonate metabolim protein, transferase hexapeptide repeat family6e-0753.1
NC_020291:4944835:496306149630614963621561Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeacetyltransferase5e-0753.1
NC_020244:4020315:404157640415764042130555Bacillus subtilis XF-1, complete genomemaltose O-acetyltransferase4e-0753.1
NC_016047:2150000:217531121753112175871561Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completemaltose O-acetyltransferase7e-0752.8
NC_015514:477935:490460490460491035576Cellulomonas fimi ATCC 484 chromosome, complete genomeisoleucine patch superfamily acetyltransferase9e-0752.4
NC_015674:1562968:156296815629681563144177Helicobacter bizzozeronii CIII-1, complete genomeacetyltransferase1e-0652
NC_014841:248487:260239260239260805567Pantoea sp. At-9b plasmid pPAT9B04, complete sequencenodulation protein L1e-0651.6
NC_016609:6022778:603412460341246034699576Niastella koreensis GR20-10 chromosome, complete genomeacetyltransferase1e-0651.6
NC_003552:484000:492073492073492648576Methanosarcina acetivorans C2A, complete genomenodulation protein L2e-0651.2
NC_013730:2359939:236271723627172363292576Spirosoma linguale DSM 74, complete genomeacetyltransferase2e-0651.2
NC_016628:1:193051930519919615Vibrio furnissii NCTC 11218 chromosome 2, complete sequenceAcetyltransferase (isoleucine patch superfamily) protein4e-0650.1
NC_013037:48900:685146851469011498Dyadobacter fermentans DSM 18053, complete genometransferase hexapeptide repeat containing protein7e-0649.3
NC_019892:5171629:518570851857085186268561Singulisphaera acidiphila DSM 18658 chromosome, complete genomeacetyltransferase8e-0649.3
NC_015572:1252000:129332712933271293929603Methylomonas methanica MC09 chromosome, complete genomeputative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ9e-0648.9