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Query: NC_009089:4140764:4157490 Clostridium difficile 630, complete genome

Start: 4157490, End: 4158458, Length: 969

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:4018451:403581240358124036780969Clostridium difficile R20291, complete genomeputative peptidase0643
NC_015425:198315:205526205526206494969Clostridium botulinum BKT015925 chromosome, complete genomepeptidase family T43e-97355
NC_008593:196257:200850200850201848999Clostridium novyi NT, complete genomePeptidase family T44e-93341
NC_015519:1205049:121481712148171215776960Tepidanaerobacter sp. Re1 chromosome, complete genomepeptidase S58 DmpA4e-82305
NC_018607:2472250:249307024930702494038969Brachyspira pilosicoli B2904 chromosome, complete genomeesterase4e-78291
NC_017243:554500:568384568384569373990Brachyspira intermedia PWS/A chromosome, complete genomenylC-like family protein1e-77290
NC_019908:1565500:158521015852101586178969Brachyspira pilosicoli P43/6/78 chromosome, complete genomeesterase1e-77290
NC_010718:2337209:2359384235938423604691086Natranaerobius thermophilus JW/NM-WN-LF, complete genomepeptidase S58 DmpA4e-77288
NC_014910:1501952:1523115152311515241281014Alicycliphilus denitrificans BC chromosome, complete genomepeptidase s58 dmpa3e-71269
NC_014624:3561756:356175635617563562727972Eubacterium limosum KIST612 chromosome, complete genomepeptidase S58 DmpA3e-71268
NC_017068:1143515:117829911782991179267969Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative peptidase2e-63242
NC_014831:149626:1515751515751527531179Thermaerobacter marianensis DSM 12885 chromosome, complete genomepeptidase S58 DmpA1e-62240
NC_009719:336000:3360363360363370731038Parvibaculum lavamentivorans DS-1 chromosome, complete genomepeptidase S58 DmpA8e-46184
NC_011420:2803196:2817336281733628184331098Rhodospirillum centenum SW, complete genomepeptidase family T4, putative2e-45183
NC_013947:1537275:154220215422021543104903Stackebrandtia nassauensis DSM 44728 chromosome, complete genomepeptidase S58 DmpA3e-42172
NC_010545:1691999:1715317171531717165131197Corynebacterium urealyticum DSM 7109, complete genomehypothetical protein4e-39162
NC_012632:538967:553861553861554712852Sulfolobus islandicus M.16.27 chromosome, complete genomepeptidase S58 DmpA3e-38159
NC_012623:2004786:202150420215042022355852Sulfolobus islandicus Y.N.15.51 chromosome, complete genomepeptidase S58 DmpA1e-37157
NC_018750:3315309:3336846333684633379371092Streptomyces venezuelae ATCC 10712, complete genomepossible hydrolase2e-32140
NC_013093:2471574:251029925102992511234936Actinosynnema mirum DSM 43827, complete genomepeptidase S58 DmpA2e-24113