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Query: NC_009089:4140764:4156716 Clostridium difficile 630, complete genome

Start: 4156716, End: 4157306, Length: 591

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:4018451:403503840350384035655618Clostridium difficile R20291, complete genomehypothetical protein6e-86316
NC_014393:187454:208501208501209106606Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein1e-37155
NC_021182:2422226:242566124256612426251591Clostridium pasteurianum BC1, complete genomehypothetical protein2e-33141
NC_017295:389500:389635389635390213579Clostridium acetobutylicum EA 2018 chromosome, complete genomehypothetical protein1e-32139
NC_015687:389500:389641389641390219579Clostridium acetobutylicum DSM 1731 chromosome, complete genomehypothetical protein1e-32139
NC_003030:389500:389645389645390223579Clostridium acetobutylicum ATCC 824, complete genomeUncharacterized membrane protein, homolog of YPAA B.subtilis1e-32139
NC_015425:198315:204840204840205409570Clostridium botulinum BKT015925 chromosome, complete genomemembrane protein5e-31134
NC_015425:1867620:188721518872151887847633Clostridium botulinum BKT015925 chromosome, complete genomemembrane protein3e-31134
NC_018664:2459994:248022024802202480981762Clostridium acidurici 9a chromosome, complete genomehypothetical protein3e-31134
NC_008593:1631438:164791616479161648512597Clostridium novyi NT, complete genomeuncharacterized membrane protein3e-30131
NC_008593:196257:200097200097200708612Clostridium novyi NT, complete genomeuncharacterized membrane protein2e-28125
NC_015958:2361551:236511223651122365648537Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehypothetical protein3e-2098.2
NC_010320:819326:833722833722834249528Thermoanaerobacter sp. X514 chromosome, complete genomehypothetical protein1e-1995.9
NC_015555:277364:285307285307285807501Thermoanaerobacterium xylanolyticum LX-11 chromosome, completemembrane protein-like protein protein2e-1995.9
NC_009922:490500:501560501560502069510Alkaliphilus oremlandii OhILAs, complete genomemembrane protein6e-1994
NC_015385:351393:369454369454370110657Treponema succinifaciens DSM 2489 chromosome, complete genomehypothetical protein4e-1270.9
NC_014624:3561756:356274735627473563340594Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein7e-1063.9