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Query: NC_009089:4140764:4146634 Clostridium difficile 630, complete genome

Start: 4146634, End: 4146825, Length: 192

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:4018451:402504840250484025239192Clostridium difficile R20291, complete genomehypothetical protein2e-27120
NC_010718:497222:514926514926515120195Natranaerobius thermophilus JW/NM-WN-LF, complete genomeprotein of unknown function DUF3782e-1167.8
NC_017208:4845281:486509348650934865326234Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein1e-0755.5
NC_014171:4708282:472903247290324729265234Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein1e-0755.5
NC_014722:193500:203652203652204068417Burkholderia rhizoxinica HKI 454, complete genomehypothetical protein2e-0651.2
NC_017297:490922:516220516220516435216Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein4e-0650.1
NC_009699:490652:515951515951516166216Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-0650.1
NC_012563:519037:544164544164544379216Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein6e-0649.7
NC_009495:482500:504799504799505014216Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-0649.7
NC_009697:444801:469575469575469790216Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-0649.7
NC_009698:467500:489963489963490178216Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein5e-0649.7
NC_010520:2585014:258802425880242588245222Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein5e-0649.7
NC_009698:2367171:237018123701812370402222Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein7e-0649.3
NC_009697:2394826:239783623978362398057222Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein7e-0649.3
NC_009495:2524000:252580425258042526034231Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein7e-0649.3
NC_010516:2511035:251403525140352514256222Clostridium botulinum B1 str. Okra, complete genomehypothetical protein9e-0648.9
NC_012563:2680246:270032527003252700546222Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein9e-0648.9