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Query: NC_009089:4140764:4144250 Clostridium difficile 630, complete genome

Start: 4144250, End: 4144939, Length: 690

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:4018451:402266440226644023368705Clostridium difficile R20291, complete genomeputative thymidylate kinase5e-132469
NC_010723:173280:211211211211211888678Clostridium botulinum E3 str. Alaska E43, complete genomethymidylate kinase1e-76285
NC_010674:192951:209394209394210071678Clostridium botulinum B str. Eklund 17B, complete genomethymidylate kinase3e-76284
NC_014328:85290:141771141771142454684Clostridium ljungdahlii ATCC 49587 chromosome, complete genomethymidylate kinase4e-74277
NC_019978:39000:577165771658384669Halobacteroides halobius DSM 5150, complete genomethymidylate kinase9e-73273
NC_008596:1933836:194975319497531950385633Mycobacterium smegmatis str. MC2 155, complete genomethymidylate kinase7e-1477.4
NC_000961:1481685:148976714897671490384618Pyrococcus horikoshii OT3, complete genomethymidylate kinase3e-1375.5
NC_003450:788000:790096790096790707612Corynebacterium glutamicum ATCC 13032, complete genomethymidylate kinase3e-1065.5
NC_010556:26567:421934219342831639Exiguobacterium sibiricum 255-15, complete genomedTMP kinase3e-0858.9
NC_012726:1263927:127638312763831276952570Sulfolobus islandicus M.16.4 chromosome, complete genomedTMP kinase1e-0756.6
NC_009828:469778:490244490244490852609Thermotoga lettingae TMO, complete genomedTMP kinase2e-0756.2
NC_013769:1294359:130773713077371308306570Sulfolobus islandicus L.D.8.5 chromosome, complete genomedTMP kinase2e-0756.2
NC_013156:633475:633475633475634035561Methanocaldococcus fervens AG86, complete genomethymidylate kinase2e-0652.8
NC_020411:114683:118226118226118828603Hydrogenobaculum sp. HO, complete genomethymidylate kinase5e-0651.2
NC_015587:114684:118227118227118829603Hydrogenobaculum sp. SHO chromosome, complete genomeThymidylate kinase5e-0651.2
NC_015557:114648:118191118191118793603Hydrogenobaculum sp. 3684 chromosome, complete genomethymidylate kinase5e-0651.2
NC_014658:417537:416967416967417557591Methanothermus fervidus DSM 2088 chromosome, complete genomethymidylate kinase6e-0651.2
NC_019970:35985:750747507475691618Thermoanaerobacterium thermosaccharolyticum M0795, complete genomethymidylate kinase7e-0650.8
NC_014410:51711:886228862289239618Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,thymidylate kinase7e-0650.8