Pre_GI: BLASTP Hits

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Query: NC_009089:3998347:4018909 Clostridium difficile 630, complete genome

Start: 4018909, End: 4019517, Length: 609

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:3863728:388431338843133884921609Clostridium difficile R20291, complete genomeputative cobalt-precorrin-6y C(5)-methyltransferase7e-108389
NC_005126:3485330:349580034958003496402603Photorhabdus luminescens subsp. laumondii TTO1, complete genomeprecorrin-6B methylase1e-53209
NC_012962:1827000:183477418347741835376603Photorhabdus asymbiotica, complete genomesynthesis of vitamin b12 adenosyl cobalamide4e-52204
NC_013892:853366:864258864258864878621Xenorhabdus bovienii SS-2004 chromosome, complete genomecobalt-precorrin-6Y C(5)-methyltransferase (Cobalt-precorrin-6 methyltransferase) (Cobalt-precorrin-6Y methylase)4e-46184
NC_011149:2040396:206692620669262067531606Salmonella enterica subsp. enterica serovar Agona str. SL483,precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit1e-43176
NC_011094:2061000:208861420886142089219606Salmonella enterica subsp. enterica serovar Schwarzengrund strcobalt-precorrin-6Y C(5)-methyltransferase3e-43174
NC_014633:442755:469171469171469800630Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceprecorrin-6Y C5,15-methyltransferase3e-36151
NC_013517:1055854:109592510959251096548624Sebaldella termitidis ATCC 33386, complete genomeprecorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit9e-35146
NC_003366:1427785:142778514277851428396612Clostridium perfringens str. 13, complete genomeprecorrin-6Y methylase3e-34144
NC_021182:1245692:125783312578331258570738Clostridium pasteurianum BC1, complete genomeprecorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit1e-32139
NC_009633:74500:927539275393373621Alkaliphilus metalliredigens QYMF chromosome, complete genomeprecorrin-6Y C5,15-methyltransferase subunit CbiE4e-32137
NC_004557:749330:7605677605677617811215Clostridium tetani E88, complete genomeprecorrin-6B methylase/decarboxylase cbiT/cbiE4e-27121
NC_014328:3482980:349087734908773491494618Clostridium ljungdahlii ATCC 49587 chromosome, complete genomecobalt-precorrin-6Y C(5)-methyltransferase1e-26119
NC_008593:2250871:225965922596592260279621Clostridium novyi NT, complete genomeprecorrin-6B methylase/decarboxylase cbiT/cbiE1e-26119
NC_010001:1702350:1719119171911917210861968Clostridium phytofermentans ISDg, complete genomeprecorrin-6x reductase1e-25115
NC_015519:488550:489620489620490261642Tepidanaerobacter sp. Re1 chromosome, complete genomeprecorrin-6y C5,15-methyltransferase subunit CbiE3e-22105
NC_014734:3086165:309627730962773096936660Paludibacter propionicigenes WB4 chromosome, complete genomeprecorriN-6y c5,15-methyltransferase (decarboxylating), cbie subunit4e-22104
NC_015565:624298:634393634393635019627Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeprecorrin-6y C5,15-methyltransferase , CbiE subunit4e-22104
NC_014483:4957315:4967470496747049687261257Paenibacillus polymyxa E681 chromosome, complete genomeProbable cobalt-precorrin-6Y C(5)-methyltransferase (Cobalt-precorrin-6 methyltransferase)1e-1996.3
NC_015690:7518732:7518732751873275200091278Paenibacillus mucilaginosus KNP414 chromosome, complete genomeCbiET protein3e-1995.1
NC_009253:2927802:293950329395032940129627Desulfotomaculum reducens MI-1 chromosome, complete genomeprecorrin-6y C5,15-methyltransferase subunit CbiE1e-1893.2
NC_016641:1085862:1094656109465610959121257Paenibacillus terrae HPL-003 chromosome, complete genomeprecorrin-6y c5,15-methyltransferase4e-1891.3
NC_019903:1058657:1063940106394010651721233Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,precorrin-6y C5,15-methyltransferase subunit CbiE/precorrin-6Y C5,15-methyltransferase subunit CbiT5e-1890.9
NC_017068:1788235:181783618178361818507672Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative cobalt-precorrin-6Y C(5)-methyltransferase6e-1890.9
NC_012491:1263469:1276131127613112773601230Brevibacillus brevis NBRC 100599, complete genomeCbiET protein7e-1890.5
NC_014622:5315500:5325758532575853270141257Paenibacillus polymyxa SC2 chromosome, complete genomeprecorrin-6y c5,15-methyltransferase8e-1890.1
NC_021171:415771:4244844244844256891206Bacillus sp. 1NLA3E, complete genomeCbiET protein2e-1685.9
NC_008148:672608:6765866765866777971212Rubrobacter xylanophilus DSM 9941, complete genomePrecorrin-6y C5,15-methyltransferase, subunit CbiE2e-1685.9
NC_015636:1061736:108212510821251082742618Methanothermococcus okinawensis IH1 chromosome, complete genomeprecorrin-6y C5,15-methyltransferase subunit CbiE1e-1583.2
NC_007681:1608223:163099416309941631617624Methanosphaera stadtmanae DSM 3091, complete genomeCbiE4e-1477.8
NC_006138:225832:2370572370572382651209Desulfotalea psychrophila LSv54, complete genomeprecorrin-6Y C5,15-methyltransferase (CobL)7e-1477
NC_012632:87590:934209342094103684Sulfolobus islandicus M.16.27 chromosome, complete genomecobalt-precorrin-6Y C(5)-methyltransferase9e-1373.6
NC_012588:87592:934229342294105684Sulfolobus islandicus M.14.25 chromosome, complete genomecobalt-precorrin-6Y C(5)-methyltransferase9e-1373.6
NC_012589:87592:934229342294105684Sulfolobus islandicus L.S.2.15, complete genomeprecorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit1e-1273.2
NC_013769:87582:934269342694109684Sulfolobus islandicus L.D.8.5 chromosome, complete genomeprecorrin-6y C5,15-methyltransferase subunit CbiE1e-1273.2
NC_017276:85380:932699326993952684Sulfolobus islandicus REY15A chromosome, complete genomeprecorrin-6y C5,15-methyltransferase(decarboxylating), CbiE subunit3e-1271.6
NC_011898:1558208:1585938158593815871251188Clostridium cellulolyticum H10, complete genomeprecorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit4e-1271.2
NC_021177:4258102:4258731425873142600351305Streptomyces fulvissimus DSM 40593, complete genomePrecorrin-6Y C(5,15)-methyltransferase5e-1270.9
NC_016791:1132451:1149200114920011504081209Clostridium sp. BNL1100 chromosome, complete genomeprecorrin-6y C5,15-methyltransferase subunit CbiE/precorrin-6Y C5,15-methyltransferase subunit CbiT5e-1167.8
NC_016627:4203775:4212079421207942132781200Clostridium clariflavum DSM 19732 chromosome, complete genomeprecorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit,precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit2e-1065.5
NC_016801:1255611:1256411125641112576911281Corynebacterium diphtheriae C7 (beta) chromosome, complete genomeprecorrin-6Y C5,15-methyltransferase3e-0858.5
NC_016790:1177349:1178150117815011794301281Corynebacterium diphtheriae VA01 chromosome, complete genomeprecorrin-6Y C5,15-methyltransferase3e-0858.5
NC_002935:1237585:1237585123758512388321248Corynebacterium diphtheriae NCTC 13129, complete genomePutative precorrin-6Y C5,15-methyltransferase3e-0858.5
NC_015519:488550:493294493294494025732Tepidanaerobacter sp. Re1 chromosome, complete genomeprecorrin-3B C17-methyltransferase5e-0857.8
NC_015065:232240:2432702432702444931224Acidobacterium sp. MP5ACTX9 plasmid pACIX902, complete sequenceprecorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit6e-0857.4
NC_013159:1807599:1833522183352218347511230Saccharomonospora viridis DSM 43017, complete genomeprecorrin-6Y C5,15-methyltransferase (decarboxylating)9e-0857
NC_015636:379000:395975395975396733759Methanothermococcus okinawensis IH1 chromosome, complete genomeprecorrin-3B C17-methyltransferase8e-0857
NC_007181:333891:343100343100343735636Sulfolobus acidocaldarius DSM 639, complete genomeprecorrin-6B methylase2e-0755.8
NC_008593:2250871:225766922576692258406738Clostridium novyi NT, complete genomeprecorrin-4 C11-methyltransferase4e-0754.7
NC_015519:488550:491506491506492246741Tepidanaerobacter sp. Re1 chromosome, complete genomeprecorrin-4 C11-methyltransferase7e-0753.9
NC_021182:1245692:126186512618651262581717Clostridium pasteurianum BC1, complete genomeprecorrin-3B C17-methyltransferase7e-0650.4
NC_004557:749330:764247764247764972726Clostridium tetani E88, complete genomeprecorrin-3B C17-methyltransferase8e-0650.4