Pre_GI: BLASTP Hits

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Query: NC_009089:3998347:4016494 Clostridium difficile 630, complete genome

Start: 4016494, End: 4017615, Length: 1122

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:3863728:3881898388189838830191122Clostridium difficile R20291, complete genomeputative cobalamin biosynthesis protein0734
NC_011149:2040396:2064565206456520656201056Salmonella enterica subsp. enterica serovar Agona str. SL483,CbiG5e-69261
NC_011094:2061000:2086253208625320873081056Salmonella enterica subsp. enterica serovar Schwarzengrund strcobalamin biosynthesis protein CbiG1e-68260
NC_013892:853366:8618408618408629041065Xenorhabdus bovienii SS-2004 chromosome, complete genomeprotein cbiG6e-67254
NC_012962:1827000:1836682183668218377431062Photorhabdus asymbiotica, complete genomecobalamin biosynthesis protein g (cbig)2e-66253
NC_005126:3485330:3493433349343334944941062Photorhabdus luminescens subsp. laumondii TTO1, complete genomecobalamin biosynthesis protein CbiG3e-66252
NC_009633:74500:9544395443965071065Alkaliphilus metalliredigens QYMF chromosome, complete genomecobalamin (vitamin B12) biosynthesis protein CbiG6e-60231
NC_004557:749330:763231763231764226996Clostridium tetani E88, complete genomecobalamin biosynthesis protein CbiG2e-54213
NC_021182:1245692:1260602126060212616871086Clostridium pasteurianum BC1, complete genomecobalamin biosynthesis protein CbiG3e-53209
NC_015519:488550:4921914921914932971107Tepidanaerobacter sp. Re1 chromosome, complete genomecobalamin (vitamin B12) biosynthesis CbiG protein1e-48194
NC_016791:1132451:1140073114007311410951023Clostridium sp. BNL1100 chromosome, complete genomecobalamin biosynthesis protein CbiG2e-48193
NC_015687:1508664:151558415155841516564981Clostridium acetobutylicum DSM 1731 chromosome, complete genomecobalamin biosynthesis protein CbiG2e-48193
NC_003030:1510000:151398315139831514963981Clostridium acetobutylicum ATCC 824, complete genomecobalamin biosynthesis protein CbiG2e-48193
NC_017295:1507956:151339715133971514377981Clostridium acetobutylicum EA 2018 chromosome, complete genomecobalamin biosynthesis protein CbiG2e-48193
NC_014633:442755:471968471968472957990Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencecobalamin (vitamin B12) biosynthesis protein CbiG1e-47190
NC_011898:1558208:1576835157683515778571023Clostridium cellulolyticum H10, complete genomecobalamin (vitamin B12) biosynthesis CbiG protein2e-47189
NC_014734:3086165:3099233309923331002401008Paludibacter propionicigenes WB4 chromosome, complete genomecobalamin (vitamin b12) biosynthesis cbig protein2e-47189
NC_010001:1702350:1717296171729617183511056Clostridium phytofermentans ISDg, complete genomecobalamin (vitamin B12) biosynthesis CbiG protein4e-47189
NC_015565:624298:6363696363696374271059Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completecobalamin (vitamin B12) biosynthesis CbiG protein1e-46187
NC_020291:3900046:3921659392165939227171059Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecobalt-precorrin 5A acetaldehyde-lyase3e-46186
NC_008593:2250871:2256626225662622576601035Clostridium novyi NT, complete genomecobalamin biosynthesis protein cbiG1e-45184
NC_014328:3482980:3487674348767434886781005Clostridium ljungdahlii ATCC 49587 chromosome, complete genomecobalamin biosynthesis protein CbiG1e-45183
NC_019903:1058657:1066730106673010678331104Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,cobalamin biosynthesis protein CbiG3e-44179
NC_009253:2927802:2937007293700729380711065Desulfotomaculum reducens MI-1 chromosome, complete genomecobalamin (vitamin B12) biosynthesis protein CbiG8e-43174
NC_016641:1085862:1092036109203610931241089Paenibacillus terrae HPL-003 chromosome, complete genomeprotein cbig3e-41169
NC_011026:2624775:2648727264872726506161890Chloroherpeton thalassium ATCC 35110, complete genomeprecorrin-4 C11-methyltransferase3e-41169
NC_013517:1055854:109864410986441099642999Sebaldella termitidis ATCC 33386, complete genomecobalamin (vitamin B12) biosynthesis CbiG protein5e-39162
NC_012491:1263469:1278846127884612799911146Brevibacillus brevis NBRC 100599, complete genomeCbiG protein4e-39162
NC_014622:5315500:5323140532314053242281089Paenibacillus polymyxa SC2 chromosome, complete genomeprotein cbig6e-39161
NC_006138:225832:2390322390322400361005Desulfotalea psychrophila LSv54, complete genomecobalamin biosynthesis protein (CbiG)4e-38159
NC_014483:4957315:4964850496485049659381089Paenibacillus polymyxa E681 chromosome, complete genomeCobalamin biosynthesis protein CbiG7e-36151
NC_016627:4203775:4221290422129042223271038Clostridium clariflavum DSM 19732 chromosome, complete genomecobalamin biosynthesis protein CbiG8e-36151
NC_010382:3350816:3360010336001033611311122Lysinibacillus sphaericus C3-41, complete genomeprotein cbiG2e-35150
NC_015574:2501869:250186925018692502861993Methanobacterium sp. SWAN-1 chromosome, complete genomecobalamin (vitamin B12) biosynthesis CbiG protein2e-35150
NC_021171:415771:4271714271714282921122Bacillus sp. 1NLA3E, complete genomecobalamin biosynthesis protein CbiG1e-35150
NC_016776:2956444:2956444295644429582431800Bacteroides fragilis 638R, complete genomeputative bifunctional CbiF/CbiG cobalamin biosynthesis protein9e-33141
NC_011059:1391734:1405703140570314075831881Prosthecochloris aestuarii DSM 271, complete genomeprecorrin-4 C11-methyltransferase2e-32140
NC_008148:672608:6777946777946794791686Rubrobacter xylanophilus DSM 9941, complete genomeprecorrin-3B C17-methyltransferase3e-29129
NC_014166:2149984:2157426215742621584421017Arcobacter nitrofigilis DSM 7299 chromosome, complete genomecobalamin (vitamin B12) biosynthesis protein CbiG2e-27124
NC_007577:1517000:1517268151726815190881821Prochlorococcus marinus str. MIT 9312, complete genomeprecorrin-3B C17-methyltransferase1e-20100
NC_007513:1900000:1901899190189919035121614Synechococcus sp. CC9902, complete genomePrecorrin-3B C17-methyltransferase region2e-1997.4
NC_009840:1485383:1544035154403515458371803Prochlorococcus marinus str. MIT 9215, complete genomebifunctional cbiH protein and precorrin-3B C17-methyltransferase2e-1997.1
NC_009091:1423677:1451388145138814531901803Prochlorococcus marinus str. MIT 9301, complete genomebifunctional cbiH protein and precorrin-3B C17-methyltransferase2e-1790.5
NC_005072:1458799:1466807146680714686271821Prochlorococcus marinus subsp. pastoris str. CCMP1986, completebifunctional cbiH protien and PRECORRIN-3B C17-METHYLTRANSFERASE5e-1789
NC_015656:2795784:2799166279916628010701905Frankia symbiont of Datisca glomerata chromosome, complete genomeprecorrin-3B C17-methyltransferase7e-1788.6
NC_007181:333891:343749343749344726978Sulfolobus acidocaldarius DSM 639, complete genomecobalamin biosynthesis protein CbiG1e-1687.4
NC_008817:1476473:1504223150422315060371815Prochlorococcus marinus str. MIT 9515, complete genomebifunctional cbiH protein and precorrin-3B C17-methyltransferase2e-1480.1
NC_003106:1809137:183793618379361838742807Sulfolobus tokodaii str. 7, complete genomecobalamin biosynthesis protein CbiG1e-1378.2
NC_013769:87582:940969409695085990Sulfolobus islandicus L.D.8.5 chromosome, complete genomecobalamin (vitamin B12) biosynthesis protein CbiG2e-1376.6
NC_012589:87592:940929409295081990Sulfolobus islandicus L.S.2.15, complete genomecobalamin (vitamin B12) biosynthesis CbiG protein2e-1376.6
NC_012588:87592:940929409295081990Sulfolobus islandicus M.14.25 chromosome, complete genomecobalamin biosynthesis protein CbiG2e-1376.6
NC_012632:87590:940909409095079990Sulfolobus islandicus M.16.27 chromosome, complete genomecobalamin biosynthesis protein CbiG2e-1376.6
NC_017276:85380:939399393994928990Sulfolobus islandicus REY15A chromosome, complete genomecobalamin (vitamin B12) biosynthesis protein CbiG2e-1376.6
NC_020829:636773:6541906541906558391650Pseudomonas denitrificans ATCC 13867, complete genomeprecorrin-3B C17-methyltransferase2e-0860.5
NC_007434:2290934:2307445230744523093041860Burkholderia pseudomallei 1710b chromosome I, complete sequenceprecorrin-3b C17-methyltransferase7e-0858.5