Pre_GI: BLASTP Hits

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Query: NC_009089:3998347:4015772 Clostridium difficile 630, complete genome

Start: 4015772, End: 4016497, Length: 726

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:3863728:388117638811763881901726Clostridium difficile R20291, complete genomecobalt-precorrin-3b c(17)-methyltransferase2e-126451
NC_011094:2061000:208552820855282086253726Salmonella enterica subsp. enterica serovar Schwarzengrund strprecorrin-3B C(17)-methyltransferase1e-83309
NC_011149:2040396:206384020638402064565726Salmonella enterica subsp. enterica serovar Agona str. SL483,precorrin-3B C17-methyltransferase1e-83308
NC_013892:853366:861121861121861846726Xenorhabdus bovienii SS-2004 chromosome, complete genomecobalt-precorrin-3B C(17)-methyltransferase4e-80297
NC_005126:3485330:349271434927143493439726Photorhabdus luminescens subsp. laumondii TTO1, complete genomeprecorrin-3B C17-methyltransferase5e-80297
NC_012962:1827000:183773718377371838462726Photorhabdus asymbiotica, complete genomeprecorrin-3b c17-methyltransferase (precorrin-3 methyltransferase (precorrin-3 methylase)1e-79296
NC_015519:488550:493294493294494025732Tepidanaerobacter sp. Re1 chromosome, complete genomeprecorrin-3B C17-methyltransferase2e-69262
NC_015687:1508664:152661915266191527335717Clostridium acetobutylicum DSM 1731 chromosome, complete genomeprecorrin-3B C17-methyltransferase4e-68258
NC_003030:1510000:152501815250181525734717Clostridium acetobutylicum ATCC 824, complete genomeprecorrin-3B C17-methyltransferase4e-68258
NC_017295:1507956:152443215244321525148717Clostridium acetobutylicum EA 2018 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase4e-68258
NC_014328:3482980:348689334868933487615723Clostridium ljungdahlii ATCC 49587 chromosome, complete genomecobalt-precorrin-3B C(17)-methyltransferase5e-67254
NC_004557:749330:764247764247764972726Clostridium tetani E88, complete genomeprecorrin-3B C17-methyltransferase1e-66252
NC_016791:1132451:114214511421451142879735Clostridium sp. BNL1100 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase1e-64246
NC_011898:1558208:157887715788771579611735Clostridium cellulolyticum H10, complete genomeprecorrin-3B C17-methyltransferase2e-64245
NC_014633:442755:472950472950473675726Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceprecorrin-3 methyltransferase2e-63241
NC_008593:2250871:225583022558302256576747Clostridium novyi NT, complete genomeprecorrin-3B C17-methyltransferase2e-62238
NC_009617:1487110:149149514914951492217723Clostridium beijerinckii NCIMB 8052 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase2e-62238
NC_021182:1245692:126186512618651262581717Clostridium pasteurianum BC1, complete genomeprecorrin-3B C17-methyltransferase1e-61236
NC_015565:624298:637421637421638131711Desulfotomaculum carboxydivorans CO-1-SRB chromosome, completeprecorrin-3B C17-methyltransferase3e-61235
NC_014734:3086165:310047331004733101207735Paludibacter propionicigenes WB4 chromosome, complete genomeprecorriN-3 methyltransferase2e-59229
NC_013517:1055854:109968810996881100410723Sebaldella termitidis ATCC 33386, complete genomeprecorrin-3B C17-methyltransferase6e-59227
NC_010001:1702350:171834817183481719076729Clostridium phytofermentans ISDg, complete genomeprecorrin-3B C17-methyltransferase4e-58224
NC_009253:2927802:293631229363122937022711Desulfotomaculum reducens MI-1 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase8e-57220
NC_009633:74500:965799657997319741Alkaliphilus metalliredigens QYMF chromosome, complete genomeprecorrin-3B C(17)-methyltransferase4e-56218
NC_010382:3350816:3367306336730633689731668Lysinibacillus sphaericus C3-41, complete genomecobalt-precorrin-3B C(17)-methyltransferase2e-56218
NC_021171:415771:4188744188744205231650Bacillus sp. 1NLA3E, complete genomeprecorrin 3 methylase8e-56216
NC_006138:225832:239958239958240728771Desulfotalea psychrophila LSv54, complete genomeprecorrin-3B C17-methyltransferase (CobJ)2e-55215
NC_014622:5315500:5330981533098153327921812Paenibacillus polymyxa SC2 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase2e-54212
NC_014483:4957315:4972779497277949745571779Paenibacillus polymyxa E681 chromosome, complete genomeCobalt-precorrin-3B C(17)-methyltransferase (Cobalt-precorrin-3 methyltransferase)3e-54211
NC_016627:4203775:421953742195374220262726Clostridium clariflavum DSM 19732 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase3e-54211
NC_016641:1085862:1099871109987111017091839Paenibacillus terrae HPL-003 chromosome, complete genomecobalt-precorrin-3B C(17)-methyltransferase1e-53209
NC_015690:7518732:7524198752419875260931896Paenibacillus mucilaginosus KNP414 chromosome, complete genomeprecorrin-3 methylase6e-53207
NC_012491:1263469:1270856127085612726131758Brevibacillus brevis NBRC 100599, complete genomeprecorrin-3 methylase7e-53207
NC_007513:1900000:1901899190189919035121614Synechococcus sp. CC9902, complete genomePrecorrin-3B C17-methyltransferase region1e-51203
NC_007355:729498:751701751701752501801Methanosarcina barkeri str. fusaro chromosome 1, complete sequenceprecorrin-3B C17-methyltransferase1e-51202
NC_007181:333891:341130341130341885756Sulfolobus acidocaldarius DSM 639, complete genomeprecorrin-3B C17-methyltransferase3e-51201
NC_019903:1058657:106786010678601068546687Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,precorrin-3 methyltransferase6e-50197
NC_005072:1458799:1466807146680714686271821Prochlorococcus marinus subsp. pastoris str. CCMP1986, completebifunctional cbiH protien and PRECORRIN-3B C17-METHYLTRANSFERASE3e-48191
NC_011059:1391734:1408793140879314102021410Prosthecochloris aestuarii DSM 271, complete genomeprecorrin-3B C17-methyltransferase2e-47189
NC_008817:1476473:1504223150422315060371815Prochlorococcus marinus str. MIT 9515, complete genomebifunctional cbiH protein and precorrin-3B C17-methyltransferase2e-47189
NC_015574:2501869:2506408250640825074691062Methanobacterium sp. SWAN-1 chromosome, complete genomeprecorrin-3B C17-methyltransferase1e-46186
NC_008148:672608:6777946777946794791686Rubrobacter xylanophilus DSM 9941, complete genomeprecorrin-3B C17-methyltransferase2e-46186
NC_003106:1809137:183548318354831836244762Sulfolobus tokodaii str. 7, complete genomeprecorrin-3B C17-methyltransferase5e-46184
NC_015636:379000:395975395975396733759Methanothermococcus okinawensis IH1 chromosome, complete genomeprecorrin-3B C17-methyltransferase7e-45180
NC_009091:1423677:1451388145138814531901803Prochlorococcus marinus str. MIT 9301, complete genomebifunctional cbiH protein and precorrin-3B C17-methyltransferase1e-44179
NC_009840:1485383:1544035154403515458371803Prochlorococcus marinus str. MIT 9215, complete genomebifunctional cbiH protein and precorrin-3B C17-methyltransferase2e-43175
NC_007577:1517000:1517268151726815190881821Prochlorococcus marinus str. MIT 9312, complete genomeprecorrin-3B C17-methyltransferase4e-41168
NC_012589:87592:981899818998935747Sulfolobus islandicus L.S.2.15, complete genomeprecorrin-3B C17-methyltransferase7e-40164
NC_012588:87592:981899818998935747Sulfolobus islandicus M.14.25 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase9e-40163
NC_012632:87590:981879818798933747Sulfolobus islandicus M.16.27 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase9e-40163
NC_017276:85380:980369803698782747Sulfolobus islandicus REY15A chromosome, complete genomeprecorrin-3B C(17)-methyltransferase9e-40163
NC_013769:87582:981939819398939747Sulfolobus islandicus L.D.8.5 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase9e-40163
NC_013159:1807599:1831240183124018327721533Saccharomonospora viridis DSM 43017, complete genomeprecorrin-2 C20-methyltransferase2e-36152
NC_016800:1219121:1236650123665012381461497Corynebacterium diphtheriae BH8 chromosome, complete genomeputative bifunctional cobalamin biosynthesis protein3e-36151
NC_016789:1232993:1252219125221912537151497Corynebacterium diphtheriae PW8 chromosome, complete genomeputative bifunctional cobalamin biosynthesis protein3e-36151
NC_016783:1216708:1234119123411912356151497Corynebacterium diphtheriae INCA 402 chromosome, complete genomeputative bifunctional cobalamin biosynthesis protein4e-36151
NC_014166:2149984:215664721566472157426780Arcobacter nitrofigilis DSM 7299 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase4e-35148
NC_020829:636773:6541906541906558391650Pseudomonas denitrificans ATCC 13867, complete genomeprecorrin-3B C17-methyltransferase1e-33143
NC_011758:326366:328427328427329197771Methylobacterium chloromethanicum CM4 plasmid pMCHL01, completeprecorrin-3B C17-methyltransferase2e-33142
NC_015065:232240:2417502417502432731524Acidobacterium sp. MP5ACTX9 plasmid pACIX902, complete sequenceprecorrin-3B C17-methyltransferase8e-33140
NC_021177:4258102:4271844427184442733791536Streptomyces fulvissimus DSM 40593, complete genomePrecorrin-3B C17-methyltransferase2e-32139
NC_007434:2290934:2307445230744523093041860Burkholderia pseudomallei 1710b chromosome I, complete sequenceprecorrin-3b C17-methyltransferase3e-28125
NC_015656:2795784:2799166279916628010701905Frankia symbiont of Datisca glomerata chromosome, complete genomeprecorrin-3B C17-methyltransferase5e-26117
NC_010511:2703684:270511927051192705970852Methylobacterium sp. 4-46 chromosome, complete genomeprecorrin-3B C(17)-methyltransferase7e-26117
NC_008595:2432184:2452417245241724539071491Mycobacterium avium 104, complete genomecobalamin biosynthesis protein cobIJ1e-24113
NC_009975:1565865:158799915879991588718720Methanococcus maripaludis C6, complete genomeuroporphyrin-III C-methyltransferase8e-0754.3
NC_013316:3863728:3876506387650638780051500Clostridium difficile R20291, complete genomeporphyrin biosynthesis protein includes: uroporphyrinogen-III methyltransferase and uroporphyrinogen-III synthase]3e-0652.4