Pre_GI: BLASTP Hits

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Query: NC_009089:3998347:4010120 Clostridium difficile 630, complete genome

Start: 4010120, End: 4011091, Length: 972

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:3863728:387552438755243876489966Clostridium difficile R20291, complete genomedelta-aminolevulinic acid dehydratase0651
NC_015275:3976631:398416739841673985135969Clostridium lentocellum DSM 5427 chromosome, complete genomePorphobilinogen synthase7e-139493
NC_015425:2144639:216040221604022161373972Clostridium botulinum BKT015925 chromosome, complete genomeporphobilinogen synthase2e-131468
NC_008593:1917118:193469119346911935662972Clostridium novyi NT, complete genomedelta-aminolevulinic acid dehydratase5e-131467
NC_015519:488550:498473498473499453981Tepidanaerobacter sp. Re1 chromosome, complete genomePorphobilinogen synthase5e-126450
NC_017295:95919:109304109304110266963Clostridium acetobutylicum EA 2018 chromosome, complete genomedelta-aminolevulinic acid dehydratase6e-122437
NC_015687:95918:109303109303110265963Clostridium acetobutylicum DSM 1731 chromosome, complete genomedelta-aminolevulinic acid dehydratase6e-122437
NC_003030:95918:109303109303110265963Clostridium acetobutylicum ATCC 824, complete genomedelta-aminolevulinic acid dehydratase6e-122437
NC_014328:3482980:349580934958093496783975Clostridium ljungdahlii ATCC 49587 chromosome, complete genomedelta-aminolevulinic acid dehydratase2e-120432
NC_009633:74500:841358413585109975Alkaliphilus metalliredigens QYMF chromosome, complete genomedelta-aminolevulinic acid dehydratase4e-118424
NC_017200:4267408:428298542829854283974990Bacillus thuringiensis serovar finitimus YBT-020 chromosome,delta-aminolevulinic acid dehydratase6e-115414
NC_011725:4428726:444058244405824441571990Bacillus cereus B4264 chromosome, complete genomedelta-aminolevulinic acid dehydratase7e-115413
NC_017208:4435573:444549444454944446483990Bacillus thuringiensis serovar chinensis CT-43 chromosome, completedelta-aminolevulinic acid dehydratase2e-114412
NC_006274:4295730:431446343144634315452990Bacillus cereus E33L, complete genomedelta-aminolevulinic acid dehydratase2e-114412
NC_011658:4243561:426137742613774262366990Bacillus cereus AH187 chromosome, complete genomedelta-aminolevulinic acid dehydratase2e-114412
NC_016771:4195888:421516042151604216149990Bacillus cereus NC7401, complete genomedelta-aminolevulinic acid dehydratase2e-114412
NC_003909:4209385:422328442232844224273990Bacillus cereus ATCC 10987, complete genomedelta-aminolevulinic acid dehydratase2e-114412
NC_008600:4263505:427635342763534277342990Bacillus thuringiensis str. Al Hakam, complete genomeporphobilinogen synthase1e-114412
NC_012472:4255729:427475442747544275743990Bacillus cereus 03BB102, complete genomedelta-aminolevulinic acid dehydratase1e-114412
NC_003997:4252000:427001942700194271008990Bacillus anthracis str. Ames, complete genomedelta-aminolevulinic acid dehydratase1e-114412
NC_007530:4251773:427014642701464271135990Bacillus anthracis str. 'Ames Ancestor', complete genomedelta-aminolevulinic acid dehydratase1e-114412
NC_005945:4251789:427051842705184271507990Bacillus anthracis str. Sterne, complete genomedelta-aminolevulinic acid dehydratase1e-114412
NC_011773:4296082:430771943077194308708990Bacillus cereus AH820 chromosome, complete genomedelta-aminolevulinic acid dehydratase1e-114412
NC_012659:4252000:427004642700464271035990Bacillus anthracis str. A0248, complete genomedelta-aminolevulinic acid dehydratase1e-114412
NC_016779:4217171:422760042276004228589990Bacillus cereus F837/76 chromosome, complete genomeporphobilinogen synthase1e-114412
NC_005957:4244019:425960142596014260590990Bacillus thuringiensis serovar konkukian str. 97-27, completedelta-aminolevulinic acid dehydratase1e-114412
NC_011772:4397599:440823044082304409219990Bacillus cereus G9842, complete genomedelta-aminolevulinic acid dehydratase1e-114412
NC_014335:4181710:420073542007354201724990Bacillus cereus biovar anthracis str. CI chromosome, completedelta-aminolevulinic acid dehydratase3e-114411
NC_014171:4317520:433082743308274331816990Bacillus thuringiensis BMB171 chromosome, complete genomedelta-aminolevulinic acid dehydratase5e-114410
NC_004722:4405363:441591644159164416905990Bacillus cereus ATCC 14579, complete genomedelta-aminolevulinic acid dehydratase5e-114410
NC_010184:4287999:430590743059074306896990Bacillus weihenstephanensis KBAB4, complete genomePorphobilinogen synthase9e-114410
NC_015589:1630461:165317916531791654162984Desulfotomaculum ruminis DSM 2154 chromosome, complete genomePorphobilinogen synthase1e-113409
NC_004557:749330:755228755228756217990Clostridium tetani E88, complete genomedelta-aminolevulinic acid dehydratase2e-113408
NC_011146:482440:4868244868244878431020Geobacter bemidjiensis Bem, complete genomedelta-aminolevulinic acid dehydratase1e-111403
NC_016791:1132451:114656611465661147543978Clostridium sp. BNL1100 chromosome, complete genomedelta-aminolevulinic acid dehydratase1e-111403
NC_010730:1519458:154045115404511541428978Sulfurihydrogenibium sp. YO3AOP1, complete genomePorphobilinogen synthase7e-111400
NC_014973:4630132:4653324465332446543431020Geobacter sp. M18 chromosome, complete genomePorphobilinogen synthase5e-110397
NC_014829:3305762:332342833234283324405978Bacillus cellulosilyticus DSM 2522 chromosome, complete genomePorphobilinogen synthase1e-109396
NC_014622:4361553:437260143726014373599999Paenibacillus polymyxa SC2 chromosome, complete genomedelta-aminolevulinic acid dehydratase (porphobilinogen synthase)2e-109395
NC_014633:442755:481302481302482279978Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequenceporphobilinogen synthase2e-109395
NC_011898:1558208:158330415833041584281978Clostridium cellulolyticum H10, complete genomedelta-aminolevulinic acid dehydratase5e-109394
NC_017068:2436960:249607724960772497057981Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative delta-aminolevulinic acid dehydratase6e-109394
NC_010001:1702350:171217017121701713165996Clostridium phytofermentans ISDg, complete genomePorphobilinogen synthase8e-109393
NC_013517:1055854:111218711121871113164978Sebaldella termitidis ATCC 33386, complete genomePorphobilinogen synthase5e-106384
NC_014314:404315:428459428459429445987Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeporphobilinogen synthase1e-104379
NC_009012:2953638:299787529978752998855981Clostridium thermocellum ATCC 27405, complete genomePorphobilinogen synthase8e-104377
NC_003552:661579:681830681830682804975Methanosarcina acetivorans C2A, complete genomedelta-aminolevulinic acid dehydratase9e-103373
NC_017052:1610500:164130416413041642287984Synechocystis sp. PCC 6803 substr. PCC-N, complete genomedelta-aminolevulinic acid dehydratase4e-102371
NC_017039:1610602:164131616413161642299984Synechocystis sp. PCC 6803 substr. PCC-P, complete genomedelta-aminolevulinic acid dehydratase4e-102371
NC_000911:1611500:164228816422881643271984Synechocystis sp. PCC 6803, complete genomedelta-aminolevulinic acid dehydratase4e-102371
NC_014734:3086165:311038831103883111374987Paludibacter propionicigenes WB4 chromosome, complete genomeporphobilinogen synthase2e-101369
NC_009663:2156206:216921721692172170188972Sulfurovum sp. NBC37-1, complete genomedelta-aminolevulinic acid dehydratase1e-101369
NC_012778:748143:7549057549057559721068Eubacterium eligens ATCC 27750, complete genomeporphobilinogen synthase3e-101368
NC_015320:409949:429764429764430711948Archaeoglobus veneficus SNP6 chromosome, complete genomePorphobilinogen synthase6e-101367
NC_018876:2380018:239008523900852391059975Methanolobus psychrophilus R15 chromosome, complete genomeporphobilinogen synthase6e-100364
NC_019977:828427:839004839004839978975Methanomethylovorans hollandica DSM 15978, complete genomedelta-aminolevulinic acid dehydratase1e-98359
NC_016627:4203775:421492942149294215909981Clostridium clariflavum DSM 19732 chromosome, complete genomedelta-aminolevulinic acid dehydratase1e-98359
NC_013520:1638000:164220416422041643178975Veillonella parvula DSM 2008, complete genomedelta-aminolevulinic acid dehydratase2e-98358
NC_011969:4140000:415792941579294158768840Bacillus cereus Q1 chromosome, complete genomedelta-aminolevulinic acid dehydratase5e-98357
NC_016627:2023750:204706320470632048043981Clostridium clariflavum DSM 19732 chromosome, complete genomedelta-aminolevulinic acid dehydratase1e-97356
NC_014122:939190:946127946127947092966Methanocaldococcus infernus ME chromosome, complete genomePorphobilinogen synthase6e-96350
NC_015177:258504:276661276661277632972Pedobacter saltans DSM 12145 chromosome, complete genomePorphobilinogen synthase8e-96350
NC_015966:2337833:2363294236329423643161023Rhodothermus marinus SG0.5JP17-172 chromosome, complete genomePorphobilinogen synthase6e-95347
NC_012526:1502975:1516970151697015179711002Deinococcus deserti VCD115, complete genomeputative Porphobilinogen synthase (Delta-aminolevulinic acid dehydratase)1e-94346
NC_015315:1717151:1717151171715117181671017Thermoproteus uzoniensis 768-20 chromosome, complete genomedelta-aminolevulinic acid dehydratase1e-92340
NC_016070:1340500:1368151136815113691731023Thermoproteus tenax Kra 1, complete genomeporphobilinogen synthase4e-92338
NC_017276:1685645:1691760169176016927701011Sulfolobus islandicus REY15A chromosome, complete genomeporphobilinogen synthase4e-92338
NC_017275:1821913:1828028182802818290381011Sulfolobus islandicus HVE10/4 chromosome, complete genomeporphobilinogen synthase4e-92338
NC_012632:1892112:1898227189822718992371011Sulfolobus islandicus M.16.27 chromosome, complete genomedelta-aminolevulinic acid dehydratase4e-92338
NC_012588:1788084:1794199179419917952091011Sulfolobus islandicus M.14.25 chromosome, complete genomedelta-aminolevulinic acid dehydratase4e-92338
NC_012589:1917421:1925643192564319266531011Sulfolobus islandicus L.S.2.15, complete genomePorphobilinogen synthase7e-92337
NC_012622:1859149:1863862186386218648721011Sulfolobus islandicus Y.G.57.14 chromosome, complete genomedelta-aminolevulinic acid dehydratase7e-92337
NC_012623:733638:7608477608477618571011Sulfolobus islandicus Y.N.15.51 chromosome, complete genomedelta-aminolevulinic acid dehydratase7e-92337
NC_013769:1908164:1912877191287719138871011Sulfolobus islandicus L.D.8.5 chromosome, complete genomeporphobilinogen synthase7e-92337
NC_012726:1792344:1798459179845917994691011Sulfolobus islandicus M.16.4 chromosome, complete genomedelta-aminolevulinic acid dehydratase2e-91336
NC_012029:11986:131641316414144981Halorubrum lacusprofundi ATCC 49239 chromosome 1, complete genomedelta-aminolevulinic acid dehydratase4e-91335
NC_014507:1558286:155951415595141560497984Methanoplanus petrolearius DSM 11571 chromosome, complete genomePorphobilinogen synthase1e-90333
NC_008701:37219:3721937219382291011Pyrobaculum islandicum DSM 4184, complete genomePorphobilinogen synthase5e-90331
NC_009481:1927995:1927995192799519289961002Synechococcus sp. WH 7803 chromosome, complete genomedelta-aminolevulinic acid dehydratase2e-89328
NC_015518:585816:592939592939593892954Acidianus hospitalis W1 chromosome, complete genomePorphobilinogen synthase7e-89327
NC_020181:527592:5565435565435575651023Enterobacter aerogenes EA1509E, complete genomePorphobilinogen synthase7e-87320
NC_005070:1837051:1837481183748118384821002Synechococcus sp. WH 8102, complete genomedelta-aminolevulinic acid dehydratase7e-87320
NC_015942:3185193:318519331851933186185993Acidithiobacillus ferrivorans SS3 chromosome, complete genomedelta-aminolevulinic acid dehydratase3e-86318
NC_006625:63342:6475264752657741023Klebsiella pneumoniae NTUH-K2044 plasmid pK2044, complete sequencedelta-aminolevulinic acid dehydratase2e-85316
NC_014761:1405408:140904014090401410011972Oceanithermus profundus DSM 14977 chromosome, complete genomeporphobilinogen synthase7e-85313
NC_014924:3065430:308189930818993082888990Pseudoxanthomonas suwonensis 11-1 chromosome, complete genomePorphobilinogen synthase1e-84313
NC_004344:129798:153868153868154842975Wigglesworthia glossinidia endosymbiont of Glossina brevipalpis,delta-aminolevulinic acid dehydratase2e-83309
NC_015731:2950874:295839629583962959361966Nitrosomonas sp. Is79A3 chromosome, complete genomedelta-aminolevulinic acid dehydratase2e-80299
NC_007954:334795:338674338674339672999Shewanella denitrificans OS217, complete genomePorphobilinogen synthase3e-80298
NC_019815:589762:5923425923425933671026Candidatus Kinetoplastibacterium crithidii (ex Angomonas deaneidelta-aminolevulinic acid dehydratase7e-80297
NC_011565:385454:389368389368390333966Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,delta-aminolevulinic acid dehydratase8e-79293
NC_019814:125611:1302331302331312491017Candidatus Kinetoplastibacterium blastocrithidii (ex Strigomonasdelta-aminolevulinic acid dehydratase7e-78290
NC_011369:1135592:1138094113809411391071014Rhizobium leguminosarum bv. trifolii WSM2304 chromosome, completedelta-aminolevulinic acid dehydratase2e-77289
NC_007109:894000:907835907835908830996Rickettsia felis URRWXCal2, complete genomedelta-aminolevulinic acid dehydratase3e-77288
NC_020299:764526:7693817693817703971017Candidatus Kinetoplastibacterium oncopeltii TCC290E, completeporphobilinogen synthase AlaD5e-77288
NC_010612:1005778:101028110102811011264984Mycobacterium marinum M, complete genomedelta-aminolevulinic acid dehydratase HemB1e-76286
NC_020133:942375:960459960459961442984Mycobacterium liflandii 128FXT, complete genomedelta-aminolevulinic acid dehydratase HemB3e-76285
NC_020064:1854589:186997818699781870946969Serratia marcescens FGI94, complete genomedelta-aminolevulinic acid dehydratase3e-76285
NC_009792:923155:942641942641943498858Citrobacter koseri ATCC BAA-895, complete genomehypothetical protein2e-73276
NC_002944:4446083:446606944660694467049981Mycobacterium avium subsp. paratuberculosis K-10, complete genomedelta-aminolevulinic acid dehydratase3e-73275
NC_007798:301456:321045321045322010966Neorickettsia sennetsu str. Miyayama, complete genomeporphobilinogen synthase4e-69261