Pre_GI: BLASTP Hits

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Query: NC_009089:3998347:4009389 Clostridium difficile 630, complete genome

Start: 4009389, End: 4009967, Length: 579

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:3863728:387479338747933875371579Clostridium difficile R20291, complete genomeputative siroheme synthase7e-83306
NC_008593:1917118:193813019381301938726597Clostridium novyi NT, complete genomesiroheme synthase, putative2e-31135
NC_015425:2144639:216385521638552164436582Clostridium botulinum BKT015925 chromosome, complete genomesiroheme synthase3e-25114
NC_015589:1630461:164731916473191647960642Desulfotomaculum ruminis DSM 2154 chromosome, complete genomesiroheme synthase4e-22104
NC_009633:74500:809718097181699729Alkaliphilus metalliredigens QYMF chromosome, complete genomesiroheme synthase2e-1788.6
NC_014829:988980:100240310024031003032630Bacillus cellulosilyticus DSM 2522 chromosome, complete genomesiroheme synthase6e-1787
NC_015064:2421034:245288024528802453542663Acidobacterium sp. MP5ACTX9 chromosome, complete genomesiroheme synthase2e-1685.5
NC_015519:488550:499435499435500004570Tepidanaerobacter sp. Re1 chromosome, complete genomesiroheme synthase3e-1685.1
NC_014622:4361553:437613643761364376783648Paenibacillus polymyxa SC2 chromosome, complete genomesiroheme synthase4e-1684.3
NC_020126:3383902:338560933856093386265657Myxococcus stipitatus DSM 14675, complete genomesiroheme synthase8e-1683.6
NC_014973:4630132:465942046594204660094675Geobacter sp. M18 chromosome, complete genomesiroheme synthase2e-1582
NC_016629:3254000:325716832571683257887720Desulfovibrio africanus str. Walvis Bay chromosome, completesiroheme synthase3e-1581.6
NC_020164:280087:292550292550293167618Staphylococcus warneri SG1, complete genomeprecorrin-2 dehydrogenase3e-1581.6
NC_014314:404315:424104424104424745642Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completesiroheme synthase4e-1581.3
NC_015172:515557:518946518946519584639Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeprecorrin-2 dehydrogenase7e-1580.1
NC_010382:3350816:335800033580003358638639Lysinibacillus sphaericus C3-41, complete genomeprecorrin-2 dehydrogenase2e-1479
NC_017353:361350:385106385106385717612Staphylococcus lugdunensis N920143, complete genomehypothetical protein2e-1478.6
NC_014972:3000138:300223530022353002900666Desulfobulbus propionicus DSM 2032 chromosome, complete genomesiroheme synthase3e-1478.2
NC_013850:985331:1003045100304510044601416Klebsiella variicola At-22 chromosome, complete genomeuroporphyrin-III C-methyltransferase3e-1374.7
NC_011126:281926:304211304211304759549Hydrogenobaculum sp. Y04AAS1, complete genomesiroheme synthase8e-1373.6
NC_013209:2384826:2386342238634223877451404Acetobacter pasteurianus IFO 3283-01, complete genomesiroheme synthase7e-1373.6
NC_017100:2383487:2387549238754923889521404Acetobacter pasteurianus IFO 3283-03, complete genomesiroheme synthase7e-1373.6
NC_017108:2383370:2384886238488623862891404Acetobacter pasteurianus IFO 3283-12, complete genomesiroheme synthase7e-1373.6
NC_017111:2383388:2384904238490423863071404Acetobacter pasteurianus IFO 3283-32, complete genomesiroheme synthase7e-1373.6
NC_017121:2383375:2384891238489123862941404Acetobacter pasteurianus IFO 3283-07, complete genomesiroheme synthase7e-1373.6
NC_017125:2383467:2387529238752923889321404Acetobacter pasteurianus IFO 3283-22, complete genomesiroheme synthase7e-1373.6
NC_017146:2383509:2387571238757123889741404Acetobacter pasteurianus IFO 3283-26, complete genomesiroheme synthase7e-1373.6
NC_017150:2290681:2294088229408822954911404Acetobacter pasteurianus IFO 3283-01-42C, complete genomesiroheme synthase7e-1373.6
NC_007350:2460134:246766024676602468271612Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,hypothetical protein3e-1271.6
NC_008571:365047:379326379326379919594Gramella forsetii KT0803, complete genomesiroheme synthase5e-1270.9
NC_019977:828427:841329841329842000672Methanomethylovorans hollandica DSM 15978, complete genomesiroheme synthase, N-terminal domain protein5e-1270.9
NC_014734:3086165:310258131025813103183603Paludibacter propionicigenes WB4 chromosome, complete genomesiroheme synthase1e-1169.7
NC_011296:801612:807728807728808363636Thermodesulfovibrio yellowstonii DSM 11347, complete genomesiroheme synthase7e-1167
NC_016632:285408:2929032929032942911389Serratia symbiotica str. 'Cinara cedri' chromosome, completeuroporphyrin-III C-methyltransferase1e-1066.2
NC_009848:1494253:151654215165421517045504Bacillus pumilus SAFR-032, complete genomeprecorrin-2 dehydrogenase6e-1063.9
NC_019940:2893535:2915948291594829173781431Thioflavicoccus mobilis 8321 chromosome, complete genomeuroporphyrin-III C-methyltransferase6e-1063.9
NC_013517:2413373:243136924313692431806438Sebaldella termitidis ATCC 33386, complete genomesiroheme synthase2e-0962.4
NC_015518:585816:595110595110595766657Acidianus hospitalis W1 chromosome, complete genomesiroheme synthase2e-0962
NC_015574:228948:233237233237233866630Methanobacterium sp. SWAN-1 chromosome, complete genomesiroheme synthase6e-0960.5
NC_018419:226000:2346532346532361521500Secondary endosymbiont of Ctenarytaina eucalypti chromosome,uroporphyrin-III C-methyltransferase8e-0960.1
NC_020389:1777409:179829617982961798967672Methanosarcina mazei Tuc01, complete genomeSiroheme synthase / Precorrin-2 oxidase/Sirohydrochlorin ferrochelatase2e-0858.9
NC_010125:148500:1735401735401749521413Gluconacetobacter diazotrophicus PAl 5, complete genomeputative siroheme synthase4e-0857.8
NC_003552:661579:679496679496680158663Methanosarcina acetivorans C2A, complete genomeuroporphyrin-III C-methyltransferase4e-0857.8
NC_012632:1892112:190043719004371901081645Sulfolobus islandicus M.16.27 chromosome, complete genomesiroheme synthase7e-0857
NC_012726:1792344:180066918006691801313645Sulfolobus islandicus M.16.4 chromosome, complete genomesiroheme synthase7e-0857
NC_017275:1821913:183023818302381830882645Sulfolobus islandicus HVE10/4 chromosome, complete genomesiroheme synthase7e-0857
NC_017276:1685645:169397016939701694614645Sulfolobus islandicus REY15A chromosome, complete genomesiroheme synthase7e-0857
NC_012588:1788084:179640917964091797053645Sulfolobus islandicus M.14.25 chromosome, complete genomesiroheme synthase7e-0857
NC_013769:1908164:191508719150871915731645Sulfolobus islandicus L.D.8.5 chromosome, complete genomesiroheme synthase1e-0756.2
NC_012622:1859149:186607218660721866716645Sulfolobus islandicus Y.G.57.14 chromosome, complete genomesiroheme synthase1e-0756.2
NC_012589:1917421:192785319278531928497645Sulfolobus islandicus L.S.2.15, complete genomesiroheme synthase1e-0756.2
NC_012623:733638:759003759003759647645Sulfolobus islandicus Y.N.15.51 chromosome, complete genomesiroheme synthase1e-0756.2
NC_007984:221030:2284092284092297971389Baumannia cicadellinicola str. Hc (Homalodisca coagulata), completesiroheme synthase2e-0755.5
NC_010001:1702350:170926817092681709735468Clostridium phytofermentans ISDg, complete genomesiroheme synthase3e-0754.7
NC_009012:2953638:299484429948442995272429Clostridium thermocellum ATCC 27405, complete genomeprecorrin-2 oxidase / ferrochelatase8e-0753.5
NC_014507:1558286:156174715617471562367621Methanoplanus petrolearius DSM 11571 chromosome, complete genomesiroheme synthase1e-0653.1
NC_015733:3736104:3830128383012838315191392Pseudomonas putida S16 chromosome, complete genomeuroporphyrin-III C-methyltransferase2e-0652.4
NC_002947:4484824:4507388450738845087791392Pseudomonas putida KT2440, complete genomeuroporphyrin-III C-methyltransferase2e-0652