Pre_GI: BLASTP Hits

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Query: NC_009089:3998347:3999672 Clostridium difficile 630, complete genome

Start: 3999672, End: 4000982, Length: 1311

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:3863728:3865053386505338663631311Clostridium difficile R20291, complete genomeABC transporter, solute-binding protein0859
NC_017218:31247:4968249682510551374Bifidobacterium breve ACS-071-V-Sch8b chromosome, complete genomeABC transporter substrate-binding protein2e-45183
NC_013526:439813:4416824416824430281347Thermobaculum terrenum ATCC BAA-798 chromosome 2, complete genomeextracellular solute-binding protein family 12e-44180
NC_011769:787496:7908717908717921661296Desulfovibrio vulgaris str. 'Miyazaki F', complete genomeextracellular solute-binding protein family 13e-38159
NC_019897:3810000:3818655381865538200731419Thermobacillus composti KWC4 chromosome, complete genomesugar ABC transporter substrate-binding protein7e-37155
NC_012669:1700626:1728388172838817297431356Beutenbergia cavernae DSM 12333, complete genomeextracellular solute-binding protein family 17e-37155
NC_011283:5011497:5033154503315450344641311Klebsiella pneumoniae 342 chromosome, complete genomeABC transporter substrate-binding protein1e-32140
NC_013850:4829455:4856074485607448573841311Klebsiella variicola At-22 chromosome, complete genomeextracellular solute-binding protein family 11e-32140
NC_016860:4024000:4046385404638540476951311Salmonella enterica subsp. enterica serovar Typhimurium strglycerol-3-phosphate-binding periplasmic protein1e-31137
NC_013592:713036:7527397527397540611323Dickeya dadantii Ech586, complete genomeextracellular solute-binding protein family 11e-30134
NC_012880:3827390:3830190383019038314971308Dickeya dadantii Ech703, complete genomeextracellular solute-binding protein family 11e-29130
NC_014844:659829:7003187003187016251308Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomefamily 1 extracellular solute-binding protein2e-29130
NC_012912:3853377:3854455385445538557771323Dickeya zeae Ech1591, complete genomeextracellular solute-binding protein family 12e-29130
NC_014761:74500:9164691646928451200Oceanithermus profundus DSM 14977 chromosome, complete genomecarbohydrate ABC transporter substrate-binding protein, cut1 family4e-29129
NC_016633:3402242:3418638341863834200021365Sphaerochaeta pleomorpha str. Grapes chromosome, complete genomesugar ABC transporter periplasmic protein7e-29128
NC_015848:3175692:3197808319780831991181311Mycobacterium canettii CIPT 140010059, complete genomeputative Sn-glycerol-3-phosphate-binding lipoprotein UGPB2e-28127
NC_020291:6310000:6326586632658663278271242Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeABC-type sugar transport system, periplasmic component1e-28127
NC_019950:3139865:3162191316219131635011311Mycobacterium canettii CIPT 140060008 complete genomePutative Sn-glycerol-3-phosphate-binding lipoprotein UgpB6e-28125
NC_014829:4088494:4107683410768341090171335Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeextracellular solute-binding protein family 11e-26120
NC_015224:279037:2931502931502944751326Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,glycerol-3-phosphate transporter periplasmic binding protein1e-25117
NC_014831:2258398:2263861226386122652011341Thermaerobacter marianensis DSM 12885 chromosome, complete genomeextracellular solute-binding protein family 15e-25115
NC_015634:2991669:2994762299476229961051344Bacillus coagulans 2-6 chromosome, complete genomeglycerol-3-phosphate ABC transporter substrate-binding protein6e-25115
NC_016641:4653889:4671448467144846727221275Paenibacillus terrae HPL-003 chromosome, complete genomefamily 1 extracellular solute-binding protein1e-24114
NC_011742:3799788:3799788379978838011041317Escherichia coli S88 chromosome, complete genomeglycerol-3-phosphate transporter periplasmic binding protein8e-24112
NC_003911:253400:2588512588512602361386Silicibacter pomeroyi DSS-3, complete genomeSN-glycerol-3-phophate ABC transporter, periplasmic SN-glycerol-3-phosphate-binding protein1e-23111
NC_016641:1984206:1986876198687619881261251Paenibacillus terrae HPL-003 chromosome, complete genomesugar ABC transporter periplasmic protein4e-23109
NC_016641:4653889:4669035466903546702971263Paenibacillus terrae HPL-003 chromosome, complete genomefamily 1 extracellular solute-binding protein2e-22107
NC_015601:436822:4556534556534569121260Erysipelothrix rhusiopathiae str. Fujisawa, complete genomeABC transporter substrate-binding protein2e-21103
NC_004668:2762464:2781265278126527825451281Enterococcus faecalis V583, complete genomeABC transporter, substrate-binding protein5e-2099.4
NC_020291:1045058:1051597105159710528561260Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeextracellular solute-binding protein, family 18e-2098.6
NC_015690:2039215:2052584205258420539121329Paenibacillus mucilaginosus KNP414 chromosome, complete genomeextracellular solute-binding protein5e-1995.9
NC_014364:815346:8707958707958721201326Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeextracellular solute-binding protein family 19e-1995.1
NC_016935:2567039:2601872260187226032001329Paenibacillus mucilaginosus 3016 chromosome, complete genomeextracellular solute-binding protein1e-1895.1
NC_010003:1126800:1137103113710311383921290Petrotoga mobilis SJ95, complete genomeextracellular solute-binding protein family 13e-1893.2
NC_017280:1584961:158523015852301586159930Campylobacter jejuni subsp. jejuni M1 chromosome, complete genomehypothetical protein5e-1892.8
NC_014958:66120:8491084910861931284Deinococcus maricopensis DSM 21211 chromosome, complete genomefamily 1 extracellular solute-binding protein2e-1790.9
NC_020453:1072979:1074707107470710758881182Agromonas oligotrophica S58 DNA, complete genomeputative sugar binding protein of ABC transporter precursor2e-1687
UCMB5137:2054735:2092017209201720933151299Bacillus atrophaeus UCMB-5137pectin degradation byproducts-binding lipoprotein2e-1687
NC_014364:3500041:3506794350679435080321239Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeextracellular solute-binding protein family 14e-1686.3
NC_014364:1899983:1918380191838019196721293Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeextracellular solute-binding protein family 15e-1685.9
NC_014246:1787154:1798378179837817996131236Mobiluncus curtisii ATCC 43063 chromosome, complete genomesugar ABC transporter substrate-binding protein8e-1685.1
NC_014958:514225:5359135359135372171305Deinococcus maricopensis DSM 21211 chromosome, complete genomefamily 1 extracellular solute-binding protein3e-1583.6
NC_014727:966779:9735809735809748751296Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,ABC superfamily ATP binding cassette transporter5e-1582.8
NC_017079:4550406:4558150455815045595291380Caldilinea aerophila DSM 14535 = NBRC 104270, complete genomeputative ABC transporter substrate binding protein1e-1481.3
NC_014652:2323598:2330356233035623315821227Caldicellulosiruptor hydrothermalis 108 chromosome, completeextracellular solute-binding protein family 12e-1480.5
NC_010572:2843589:2863797286379728650441248Streptomyces griseus subsp. griseus NBRC 13350, complete genomeputative ABC transporter substrate-binding protein3e-1480.1
NC_021182:966839:9705849705849718611278Clostridium pasteurianum BC1, complete genomeABC-type sugar transport system, periplasmic component4e-1479.7
NC_009437:475817:4947954947954960211227Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeextracellular solute-binding protein9e-1478.6
NC_014334:2696000:2713981271398127153571377Lactobacillus casei str. Zhang chromosome, complete genomesugar ABC transporter periplasmic protein2e-1377.8
NC_016641:4011000:4028112402811240294521341Paenibacillus terrae HPL-003 chromosome, complete genomefamily 1 extracellular solute-binding protein2e-1377.8
NC_010511:6067000:6127720612772061290901371Methylobacterium sp. 4-46 chromosome, complete genomeextracellular solute-binding protein2e-1377.4
NC_014721:373607:3913783913783926041227Caldicellulosiruptor kristjanssonii 177R1B chromosome, completeextracellular solute-binding protein family 12e-1377.4
NC_015949:2101302:2106691210669121079171227Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomefamily 1 extracellular solute-binding protein2e-1377
NC_014720:2420455:2437885243788524391111227Caldicellulosiruptor kronotskyensis 2002 chromosome, completeextracellular solute-binding protein family 13e-1376.6
NC_012034:438000:4587584587584599841227Anaerocellum thermophilum DSM 6725, complete genomeextracellular solute-binding protein family 13e-1376.6
NC_014364:815346:8385568385568398301275Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeextracellular solute-binding protein family 13e-1376.6
NC_014392:412916:4339374339374351631227Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomeextracellular solute-binding protein family 15e-1375.9
NC_013174:309943:3295333295333308551323Jonesia denitrificans DSM 20603, complete genomeextracellular solute-binding protein family 11e-1274.7
NC_011899:86800:9030190301915361236Halothermothrix orenii H 168, complete genomeextracellular solute-binding protein family 13e-1273.6
NC_012669:4118230:4129844412984441311091266Beutenbergia cavernae DSM 12333, complete genomeextracellular solute-binding protein family 13e-1273.6
NC_014212:3091571:3099872309987231012211350Meiothermus silvanus DSM 9946 chromosome, complete genomeextracellular solute-binding protein family 12e-1273.6
NC_019970:929666:9492049492049505231320Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeABC-type sugar transport system, periplasmic component2e-1273.6
NC_014644:1532500:1554471155447115556941224Gardnerella vaginalis ATCC 14019 chromosome, complete genomeABC transporter binding protein1e-1171.6
NC_013202:906044:9060449060449073451302Halomicrobium mukohataei DSM 12286, complete genomeextracellular solute-binding protein family 12e-1170.5
NC_017179:2895571:2895571289557128968451275Clostridium difficile BI1, complete genomeextracellular solute-binding protein9e-1168.6
NC_013315:2887559:2887559288755928888331275Clostridium difficile CD196 chromosome, complete genomeextracellular solute-binding protein9e-1168.6
NC_013316:2968000:2968117296811729693911275Clostridium difficile R20291, complete genomeputative extracellular solute-binding protein9e-1168.6
NC_005773:5149768:5164737516473751660531317Pseudomonas syringae pv. phaseolicola 1448A, complete genomeglycerol-3-phosphate ABC transporter, periplasmic glycerol-3-phosphate-binding protein2e-1067.4
NC_014206:1694330:1714328171432817156381311Geobacillus sp. C56-T3 chromosome, complete genomefamily 1 extracellular solute-binding protein3e-1066.6
NC_015602:1143038:1151785115178511530861302Lactobacillus kefiranofaciens ZW3 chromosome, complete genomeglycerol-3-phosphate ABC transporter3e-1066.6
NC_020134:1783000:1783007178300717843291323Clostridium stercorarium subsp. stercorarium DSM 8532, completeextracellular solute-binding protein, family 14e-1066.2
NC_014831:1818968:1838590183859018399481359Thermaerobacter marianensis DSM 12885 chromosome, complete genomecarbohydrate ABC transporter substrate-binding protein, CUT1 family7e-1065.5
NC_016616:3585435:3607849360784936092131365Dechlorosoma suillum PS chromosome, complete genomesugar ABC transporter periplasmic protein8e-1065.5
NC_013721:1204566:1214195121419512156371443Gardnerella vaginalis 409-05, complete genomebacterial extracellular solute-binding protein9e-1065.1
NC_009380:3043140:3066965306696530683051341Salinispora tropica CNB-440 chromosome, complete genomehypothetical protein1e-0965.1
NC_015520:2859820:2864204286420428655201317Mahella australiensis 50-1 BON chromosome, complete genomefamily 1 extracellular solute-binding protein3e-0963.5
NC_013172:466300:4684394684394697731335Brachybacterium faecium DSM 4810, complete genomeABC-type sugar transport system, periplasmic component3e-0963.5
NC_014364:4488875:4533226453322645345061281Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeextracellular solute-binding protein family 14e-0963.2
NC_014652:757381:7573817573817587451365Caldicellulosiruptor hydrothermalis 108 chromosome, completeextracellular solute-binding protein family 14e-0963.2
NC_020210:1951746:1962799196279919641211323Geobacillus sp. GHH01, complete genomeExtracellular solute-binding protein family 15e-0962.8
NC_013521:302574:3200153200153212951281Sanguibacter keddieii DSM 10542, complete genomecarbohydrate-binding protein8e-0962
NC_014915:1909275:1921556192155619229171362Geobacillus sp. Y412MC52 chromosome, complete genomeextracellular solute-binding protein family 19e-0962
NC_013411:2767400:2781619278161927829831365Geobacillus sp. Y412MC61, complete genomeextracellular solute-binding protein family 19e-0962
NC_016935:1365463:1418581141858114199781398Paenibacillus mucilaginosus 3016 chromosome, complete genomefamily 1 extracellular solute-binding protein1e-0861.6
NC_015690:3941113:3999206399920640005281323Paenibacillus mucilaginosus KNP414 chromosome, complete genomefamily 1 extracellular solute-binding protein1e-0861.2
NC_009952:526456:5340715340715354141344Dinoroseobacter shibae DFL 12, complete genomeABC-type sugar / sn-glycerol 3-phosphate transport protein2e-0861.2
NC_010407:1775227:1784339178433917856341296Clavibacter michiganensis subsp. sepedonicus chromosome, completeputative substrate-binding transport2e-0861.2
NC_015052:2383865:2388169238816923895091341Bifidobacterium longum subsp. infantis 157F, complete genomeABC transporter substrate-binding protein2e-0860.8
NC_007005:5367454:5366138536613853674571320Pseudomonas syringae pv. syringae B728a, complete genomeextracellular solute-binding protein, family 12e-0860.8
NC_008618:200017:2074392074392087191281Bifidobacterium adolescentis ATCC 15703, complete genomesolute binding protein of ABC transporter system2e-0860.5
NC_015671:874500:8980898980898994231335Cellvibrio gilvus ATCC 13127 chromosome, complete genomefamily 1 extracellular solute-binding protein3e-0860.1
NC_016582:7946000:7952288795228879535861299Streptomyces bingchenggensis BCW-1 chromosome, complete genomeMalE-type ABC sugar transport system periplasmic component4e-0859.7
NC_013131:7945280:7972883797288379740971215Catenulispora acidiphila DSM 44928, complete genomeextracellular solute-binding protein family 15e-0859.7
NC_013521:302574:3359023359023371611260Sanguibacter keddieii DSM 10542, complete genomeABC-type sugar transport system, periplasmic component5e-0859.3
NC_009328:448224:4564704564704577231254Geobacillus thermodenitrificans NG80-2 chromosome, complete genomesugar transporter sugar binding protein6e-0859.3
NC_013406:3926531:3941852394185239432551404Paenibacillus sp. Y412MC10 chromosome, complete genomefamily 1 extracellular solute-binding protein6e-0858.9
NC_016935:2918689:2938022293802229393321311Paenibacillus mucilaginosus 3016 chromosome, complete genomefamily 1 extracellular solute-binding protein7e-0858.9
NC_014364:1263427:1278910127891012802081299Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeextracellular solute-binding protein family 11e-0758.2
NC_007760:4751000:4759345475934547605471203Anaeromyxobacter dehalogenans 2CP-C, complete genomeABC sugar transporter, periplasmic ligand binding protein1e-0758.2
NC_017221:2268276:2284399228439922855711173Bifidobacterium longum subsp. longum KACC 91563 chromosome,ABC transporter substrate-binding protein1e-0758.2
NC_016641:2773757:2775512277551227768281317Paenibacillus terrae HPL-003 chromosome, complete genomefamily 1 extracellular solute-binding protein1e-0758.2
NC_020291:4502467:4509612450961245110751464Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecarbohydrate ABC transporter substrate-binding protein, CUT1 family2e-0757.8
NC_014829:1154520:1155755115575511570861332Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeextracellular solute-binding protein family 13e-0757
NC_013406:303218:3367583367583380501293Paenibacillus sp. Y412MC10 chromosome, complete genomefamily 1 extracellular solute-binding protein3e-0757
NC_015577:1462874:1482972148297214842281257Treponema azotonutricium ZAS-9 chromosome, complete genomeputative bacterial extracellular solute-binding protein9e-0755.1
NC_011145:4797548:4807758480775848089601203Anaeromyxobacter sp. K, complete genomeextracellular solute-binding protein family 12e-0654.3
NC_017954:161787:1874481874481890011554Thermogladius cellulolyticus 1633 chromosome, complete genomecyclomaltodextrin binding protein3e-0653.5
NC_013656:2317224:2320566232056623218101245Lactococcus lactis subsp. lactis KF147, complete genomesugar ABC transporter sugar-binding protein3e-0653.5
NC_012926:140000:1543541543541556281275Streptococcus suis BM407 chromosome, complete genomeextracellular solute-binding lipoprotein4e-0653.1
NC_012924:142500:1543751543751556491275Streptococcus suis SC84, complete genomeextracellular solute-binding lipoprotein4e-0653.1
NC_012925:140000:1545701545701558441275Streptococcus suis P1/7, complete genomeextracellular solute-binding lipoprotein4e-0653.1
NC_009443:142500:1541291541291555561428Streptococcus suis 98HAH33, complete genomesugar ABC transporter periplasmic protein4e-0653.1
NC_012491:6143928:6148872614887261501701299Brevibacillus brevis NBRC 100599, complete genomeprobable ABC transporter substrate binding protein4e-0653.1
NC_017079:4550406:4564677456467745660771401Caldilinea aerophila DSM 14535 = NBRC 104270, complete genomeputative ABC transporter substrate binding protein5e-0652.8
NC_014829:4088494:4103947410394741052421296Bacillus cellulosilyticus DSM 2522 chromosome, complete genomeextracellular solute-binding protein family 15e-0652.8
NC_015637:669593:6811046811046822851182Vibrio anguillarum 775 chromosome chromosome II, complete sequencemaltose/maltodextrin-binding protein5e-0652.8
NC_015953:5865733:5905559590555959068211263Streptomyces sp. SirexAA-E chromosome, complete genomefamily 1 extracellular solute-binding protein5e-0652.8
NC_013517:773280:7751637751637764041242Sebaldella termitidis ATCC 33386, complete genomeextracellular solute-binding protein family 17e-0652.4
NC_004460:1313468:1337845133784513389751131Vibrio vulnificus CMCP6 chromosome II, complete sequenceperiplasmic maltose-binding protein7e-0652.4
NC_013093:2132284:2140041214004121413601320Actinosynnema mirum DSM 43827, complete genomeextracellular solute-binding protein family 19e-0652