Some Help

Query: NC_009089:3998347:3998347 Clostridium difficile 630, complete genome

Start: 3998347, End: 3999609, Length: 1263

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:3863728:3863728386372838649901263Clostridium difficile R20291, complete genomeputative nucleotide pyrophosphatase0804
NC_008593:1917118:1956619195661919579321314Clostridium novyi NT, complete genometype I phosphodiesterase/nucleotide pyrophosphatase family protein4e-60232
NC_016011:1419394:1438829143882914400971269Listeria ivanovii subsp. ivanovii PAM 55, complete genomeputative pyrophosphatase2e-59229
NC_015425:2144639:2184324218432421856041281Clostridium botulinum BKT015925 chromosome, complete genometype I phosphodiesterase/nucleotide pyrophosphatase family protein1e-58227
NC_019903:134169:1368121368121380891278Desulfitobacterium dichloroeliminans LMG P-21439 chromosome,AP superfamily protein5e-55215
NC_014376:2921769:2926742292674229280761335Clostridium saccharolyticum WM1 chromosome, complete genometype I phosphodiesterase/nucleotide pyrophosphatase3e-52206
NC_014963:3530097:3543300354330035446371338Terriglobus saanensis SP1PR4 chromosome, complete genometype I phosphodiesterase/nucleotide pyrophosphatase2e-35150
NC_014804:189368:2053062053062064271122Thermococcus barophilus MP chromosome, complete genomealkaline phosphodiesterase I5e-23108
NC_016012:135500:1482401482401495321293Candidatus Arthromitus sp. SFB-rat-Yit, complete genometype I phosphodiesterase/nucleotide pyrophosphatase1e-22107
NC_015913:178451:1911731911731924621290Candidatus Arthromitus sp. SFB-mouse-Japan, complete genometype I phosphodiesterase/nucleotide1e-20100
NC_013061:3390399:3408627340862734100011375Pedobacter heparinus DSM 2366, complete genome3e-1893.2