Pre_GI: BLASTP Hits

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Query: NC_009089:3782000:3801552 Clostridium difficile 630, complete genome

Start: 3801552, End: 3802865, Length: 1314

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:3621306:3635195363519536365081314Clostridium difficile BI1, complete genomeelectron transfer protein0874
NC_013315:3613288:3627177362717736284901314Clostridium difficile CD196 chromosome, complete genomeelectron transfer protein0874
NC_009698:2450606:2463731246373124650351305Clostridium botulinum A str. Hall chromosome, complete genomeelectron transport protein9e-121434
NC_009697:2478261:2491386249138624926901305Clostridium botulinum A str. ATCC 19397 chromosome, completeelectron transport protein9e-121434
NC_009495:2606238:2619269261926926205731305Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeelectron transferring subunit of proline reductase1e-120433
NC_012563:2761570:2793639279363927949431305Clostridium botulinum A2 str. Kyoto, complete genomeputative electron transport protein1e-120433
NC_009699:2654672:2667794266779426690981305Clostridium botulinum F str. Langeland chromosome, complete genomeelectron transport protein1e-120433
NC_017297:2635892:2667942266794226692461305Clostridium botulinum F str. 230613 chromosome, complete genomeputative electron transport protein1e-120433
NC_010516:2594159:2607315260731526086191305Clostridium botulinum B1 str. Okra, complete genomeputative electron transport protein1e-120433
NC_012658:2641446:2674696267469626760001305Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative electron transport protein1e-120433
NC_010520:2668702:2681811268181126831151305Clostridium botulinum A3 str. Loch Maree, complete genomeputative electron transport protein3e-120432
NC_010516:2594159:2611158261115826124681311Clostridium botulinum B1 str. Okra, complete genomeputative electron transport protein4e-118424
NC_012658:2641446:2678542267854226798521311Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative electron transport protein6e-117421
NC_009495:2606238:2623112262311226244221311Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeelectron transferring subunit of proline reductase4e-117421
NC_009697:2478261:2495229249522924965391311Clostridium botulinum A str. ATCC 19397 chromosome, completeelectron transport protein4e-117421
NC_009698:2450606:2467574246757424688841311Clostridium botulinum A str. Hall chromosome, complete genomeelectron transport protein4e-117421
NC_012563:2761570:2797497279749727988071311Clostridium botulinum A2 str. Kyoto, complete genomeputative electron transport protein4e-117421
NC_010520:2668702:2685656268565626869661311Clostridium botulinum A3 str. Loch Maree, complete genomeputative electron transport protein9e-117420
NC_009699:2654672:2671477267147726727871311Clostridium botulinum F str. Langeland chromosome, complete genomeelectron transport protein5e-116417
NC_010516:2567911:2586690258669025878081119Clostridium botulinum B1 str. Okra, complete genomeputative electron transport protein2e-95349
NC_017297:2635892:2647309264730926484271119Clostridium botulinum F str. 230613 chromosome, complete genomeputative electron transport protein5e-95348
NC_012658:2641446:2656704265670426578221119Clostridium botulinum Ba4 str. 657 chromosome, complete genome9e-95347
NC_012563:2761570:2772988277298827741061119Clostridium botulinum A2 str. Kyoto, complete genomeputative electron transport protein1e-94347
NC_012658:2641446:2672240267224026733581119Clostridium botulinum Ba4 str. 657 chromosome, complete genome6e-94345
NC_009698:2450606:2461270246127024623881119Clostridium botulinum A str. Hall chromosome, complete genomeNADH dehydrogenase7e-94344
NC_009495:2606238:2616809261680926179271119Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeelectron transferring subunit of proline reductase7e-94344
NC_017297:2635892:2665483266548326666011119Clostridium botulinum F str. 230613 chromosome, complete genomeputative electron transport protein1e-93343
NC_010516:2594159:2604854260485426059721119Clostridium botulinum B1 str. Okra, complete genomeputative electron transport protein2e-93343
NC_010520:2668702:2679350267935026804681119Clostridium botulinum A3 str. Loch Maree, complete genomeputative electron transport protein2e-93342
NC_012563:2761570:2791178279117827922961119Clostridium botulinum A2 str. Kyoto, complete genomeputative electron transport protein2e-93342
NC_013316:1186156:1192232119223211935691338Clostridium difficile R20291, complete genomeelectron transport complex protein2e-43176
NC_009089:1329826:1336456133645613377931338Clostridium difficile 630, complete genomeelectron transport complex protein2e-43176
NC_013315:1187986:1194616119461611959531338Clostridium difficile CD196 chromosome, complete genomeelectron transport complex protein2e-43176
NC_017179:1197763:1204393120439312057301338Clostridium difficile BI1, complete genomeelectron transport complex protein2e-43176
NC_009697:419443:4220884220884234071320Clostridium botulinum A str. ATCC 19397 chromosome, completeRnfABCDGE type electron transport complex subunit C1e-41171
NC_010718:517473:5227055227055240271323Natranaerobius thermophilus JW/NM-WN-LF, complete genomeelectron transport complex, RnfABCDGE type, C subunit4e-40166
NC_003454:63500:1059431059431072681326Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeNitrogen fixation iron-sulphur protein RNFC2e-39163
NC_017096:1147441:1169499116949911709111413Caldisericum exile AZM16c01, complete genomeelectron transport complex protein RnfC8e-38158
NC_011661:1100576:1113734111373411150471314Dictyoglomus turgidum DSM 6724, complete genomeelectron transport complex, RnfABCDGE type, C subunit9e-37154
NC_009633:2350892:2350892235089223522201329Alkaliphilus metalliredigens QYMF chromosome, complete genomeRnfABCDGE type electron transport complex subunit C1e-35151
NC_016614:686887:6868876868876884641578Vibrio sp. EJY3 chromosome 2, complete sequenceelectron transport complex protein rnfC8e-34145
NC_014632:11925:2101721017223271311Ilyobacter polytropus DSM 2926 chromosome, complete genomeRnfABCDGE type electron transport complex subunit C1e-33144
NC_020291:744329:7466997466997480181320Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeelectron transport complex protein RnfC4e-33142
NC_017095:166896:1940961940961954031308Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeRnfABCDGE type electron transport complex subunit C4e-33142
NC_015709:1459838:1509607150960715110731467Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completeRnfABCDGE type electron transport complex subunit C4e-33142
NC_013959:826868:8459138459138473911479Sideroxydans lithotrophicus ES-1 chromosome, complete genomeelectron transport complex, RnfABCDGE type, C subunit2e-31137
NC_013194:4964000:4981008498100849825341527Candidatus Accumulibacter phosphatis clade IIA str. UW-1, completeelectron transport complex, RnfABCDGE type, C subunit4e-31136
NC_015578:3980496:4028093402809340294961404Treponema primitia ZAS-2 chromosome, complete genomeelectron transport complex protein RnfC2e-30134
NC_010001:1488000:1499464149946415007921329Clostridium phytofermentans ISDg, complete genomeRespiratory-chain NADH dehydrogenase domain 51 kDa subunit9e-30131
NC_018515:1663912:1678000167800016793431344Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeNADH:ubiquinone oxidoreductase, subunit RnfC3e-29130
NC_006138:857692:8670058670058683211317Desulfotalea psychrophila LSv54, complete genomeelectron transport complex protein3e-28126
NC_007907:456164:4740524740524754431392Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-27124
NC_010723:1967106:1974326197432619756511326Clostridium botulinum E3 str. Alaska E43, complete genomeethanolamine utilization Fe-S center protein eut3e-26119
NC_016613:1877688:1878236187823618796031368Vibrio sp. EJY3 chromosome 1, complete sequencerespiratory-chain NADH dehydrogenase domain 51 kDa subunit5e-26119
NC_007519:3240864:3261406326140632627341329Desulfovibrio alaskensis G20 chromosome, complete genomeelectron transfer protein (PduS)6e-26119
NC_014121:2330451:2358067235806723598901824Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeelectron transport complex protein RnfC1e-25118
NC_016584:1714507:1724022172402217253621341Desulfosporosinus orientis DSM 765 chromosome, complete genomeNADH:ubiquinone oxidoreductase, subunit RnfC7e-26118
NC_009253:1381401:1392594139259413939161323Desulfotomaculum reducens MI-1 chromosome, complete genomerespiratory-chain NADH dehydrogenase domain-containing protein2e-25117
NC_011837:830436:8555068555068568341329Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-25117
NC_010674:1822963:1834020183402018353451326Clostridium botulinum B str. Eklund 17B, complete genomeethanolamine utilization Fe-S center protein eut2e-25117
NC_009706:830461:8515598515598528841326Clostridium kluyveri DSM 555 chromosome, complete genomeRnfC related NADH dehydrogenase2e-25117
NC_009706:830461:8555348555348568591326Clostridium kluyveri DSM 555 chromosome, complete genomeRnfC related NADH dehydrogenase2e-25117
NC_011837:830436:8515348515348528591326Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-25117
NC_016584:1998000:2031783203178320331231341Desulfosporosinus orientis DSM 765 chromosome, complete genomeNADH:ubiquinone oxidoreductase, subunit RnfC7e-25115
NC_011740:2072173:2073282207328220746221341Escherichia fergusonii ATCC 35469, complete genomeputative propanediol utilization protein: ferredoxin pduS3e-24113
NC_009633:3933941:3944504394450439458411338Alkaliphilus metalliredigens QYMF chromosome, complete genomerespiratory-chain NADH dehydrogenase domain-containing protein4e-23109
NC_008309:1155218:1174542117454211765211980Haemophilus somnus 129PT, complete genomeelectron transport complex protein3e-23109
NC_010519:1764261:1777691177769117798112121Haemophilus somnus 2336 chromosome, complete genomeelectron transporter subunit RnfC1e-22107
NC_010723:1465097:1480088148008814814161329Clostridium botulinum E3 str. Alaska E43, complete genomerespiratory-chain NADH dehydrogenase domain, 51 kda subunit3e-22106
NC_009922:2556033:2568096256809625694241329Alkaliphilus oremlandii OhILAs, complete genomeRespiratory-chain NADH dehydrogenase domain 51 kDa subunit5e-22105
NC_011837:830436:8575168575168588471332Clostridium kluyveri NBRC 12016, complete genomehypothetical protein6e-22105
NC_011837:830436:8535418535418548721332Clostridium kluyveri NBRC 12016, complete genomehypothetical protein6e-22105
NC_009706:830461:8576458576458589731329Clostridium kluyveri DSM 555 chromosome, complete genomeRnfC related NADH dehydrogenase6e-22105
NC_009706:830461:8535698535698548971329Clostridium kluyveri DSM 555 chromosome, complete genomeRnfC related NADH dehydrogenase6e-22105
NC_016584:5625975:5634980563498056363171338Desulfosporosinus orientis DSM 765 chromosome, complete genomeNADH:ubiquinone oxidoreductase, subunit RnfC2e-21104
NC_014328:4316008:4326216432621643275441329Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative RnfC related NADH dehydrogenase1e-21104
NC_018870:705900:7311347311347324651332Thermacetogenium phaeum DSM 12270 chromosome, complete genomeputative NADH:ubiquinone oxidoreductase6e-21102
NC_014633:442755:4465294465294478721344Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequencerespiratory-chain NADH dehydrogenase domain 51 kDa subunit6e-21102
NC_014654:1113116:1129372112937211307211350Halanaerobium sp. 'sapolanicus' chromosome, complete genomeRespiratory-chain NADH dehydrogenase domain 51 kDa subunit3e-20100
NC_010674:1496500:1509875150987515112031329Clostridium botulinum B str. Eklund 17B, complete genomerespiratory-chain NADH dehydrogenase domain, 51 kda subunit3e-20100
NC_017243:1813158:1819282181928218209431662Brachyspira intermedia PWS/A chromosome, complete genomehypothetical protein2e-1997.4
NC_014614:284005:3039403039403052771338Clostridium sticklandii, complete genomeRespiratory-chain NADH dehydrogenase domain, 51 kDa subunit3e-1996.7
NC_007955:1464000:1473614147361414749751362Methanococcoides burtonii DSM 6242, complete genomeelectron transport complex, RnfABCDGE type, C subunit6e-1892.4
NC_015567:2328782:2348192234819223504622271Serratia sp. AS9 chromosome, complete genomeElectron transport complex protein rnfC1e-1791.3
NC_015566:2328771:2348181234818123505802400Serratia sp. AS12 chromosome, complete genomeElectron transport complex protein rnfC2e-1790.5
NC_009633:286677:3036153036153049611347Alkaliphilus metalliredigens QYMF chromosome, complete genomerespiratory-chain NADH dehydrogenase domain-containing protein6e-1789
NC_015424:2836920:2850483285048328531942712Aeromonas veronii B565 chromosome, complete genomeRnfABCDGE type electron transport complex subunit C1e-1584.7
NC_016816:2508204:2530624253062425331972574Pantoea ananatis LMG 5342, complete genomeRnfABCDGE type electron transport complex subunit C1e-1481.3
NC_009348:2631759:2649127264912726513882262Aeromonas salmonicida subsp. salmonicida A449, complete genomeelectron transport complex protein RnfC2e-1480.5
NC_010520:2668702:267915226791522679328177Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein1e-1274.7
NC_012658:2641446:267204226720422672218177Clostridium botulinum Ba4 str. 657 chromosome, complete genome1e-1274.7
NC_009698:2450606:246107224610722461248177Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein1e-1274.7
NC_017297:2635892:264711726471172647287171Clostridium botulinum F str. 230613 chromosome, complete genomeputative electron transport protein2e-1273.9
NC_012658:2641446:265651226565122656682171Clostridium botulinum Ba4 str. 657 chromosome, complete genome2e-1273.9
NC_012563:2761570:277279627727962772966171Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-1273.9
NC_010516:2567911:258649825864982586668171Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-1273.9
NC_012563:2761570:279098027909802791156177Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-1273.6
NC_010516:2594159:260465626046562604832177Clostridium botulinum B1 str. Okra, complete genomehypothetical protein4e-1273.2
NC_009495:2606238:261661126166112616787177Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein4e-1273.2
NC_017297:2635892:266528526652852665461177Clostridium botulinum F str. 230613 chromosome, complete genomeputative electron transport protein4e-1273.2
NC_017297:2635892:267270026727002672936237Clostridium botulinum F str. 230613 chromosome, complete genome5e-1272.8
NC_015216:2548057:2563084256308425649431860Methanobacterium sp. AL-21 chromosome, complete genomeNADH dehydrogenase (quinone)2e-0964.3
NC_015275:443213:4450174450174461201104Clostridium lentocellum DSM 5427 chromosome, complete genomeRespiratory-chain NADH dehydrogenase domain 51 kDa subunit2e-0964.3
NC_007498:1072112:1080314108031410820291716Pelobacter carbinolicus DSM 2380, complete genomeNADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit7e-0858.9
NC_017096:1147441:1158594115859411602491656Caldisericum exile AZM16c01, complete genomeputative NADH dehydrogenase subunit1e-0757.8
NC_018870:1506918:1506918150691815088401923Thermacetogenium phaeum DSM 12270 chromosome, complete genomeNADH-quinone oxidoreductase 51 kDa subunit F2e-0757.8
NC_004347:1038253:1055382105538210567671386Shewanella oneidensis MR-1, complete genomeNADH dehydrogenase I, F subunit6e-0755.8
NC_020409:135699:1594381594381606731236Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeputative Electron transport complex protein RnfC8e-0755.5
NC_017955:3670670:3695193369519336965601368Modestobacter marinus, complete genomeNADH dehydrogenase (quinone)8e-0755.5
NC_012785:205502:2055022055022071211620Kosmotoga olearia TBF 19.5.1, complete genomeNADH dehydrogenase (quinone)7e-0755.5
NC_009922:315870:3255043255043272521749Alkaliphilus oremlandii OhILAs, complete genomeNADH dehydrogenase (quinone)9e-0755.1
NC_009437:685214:6885706885706903241755Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeNADH dehydrogenase (quinone)1e-0654.7
NC_010554:1871000:1883715188371518850791365Proteus mirabilis HI4320, complete genomeNADH-quinone oxidoreductase chain F1e-0654.7
NC_014228:2812000:2815882281588228172461365Xenorhabdus nematophila ATCC 19061, complete genomeNADH dehydrogenase I chain F1e-0654.7
NC_017253:155170:1679971679971693311335Buchnera aphidicola str. JF99 (Acyrthosiphon pisum) chromosome,NADH dehydrogenase I chain F2e-0653.9
NC_011832:820658:8709698709698726571689Candidatus Methanosphaerula palustris E1-9c, complete genomeNADH dehydrogenase (quinone)3e-0653.5
NC_008610:253483:2552032552032564711269Candidatus Ruthia magnifica str. Cm (Calyptogena magnifica),NADH-quinone oxidoreductase, F subunit3e-0653.5
NC_014972:2328228:2358047235804723596631617Desulfobulbus propionicus DSM 2032 chromosome, complete genomeNAD(P)-dependent nickel-iron dehydrogenase flavin-containing subunit3e-0653.5
NC_004545:141478:1642691642691656031335Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genomeNADH dehydrogenase I chain F4e-0653.1
NC_017096:1147441:1156560115656011582031644Caldisericum exile AZM16c01, complete genomeputative formate dehydrogenase beta subunit6e-0652.8
NC_011833:147426:1679851679851693191335Buchnera aphidicola str. 5A (Acyrthosiphon pisum) chromosome,NADH dehydrogenase I subunit F6e-0652.8
NC_004061:166375:1686741686741700171344Buchnera aphidicola str. Sg (Schizaphis graminum), complete genomeNADH dehydrogenase I chain F6e-0652.8
NC_010694:1324250:1344252134425213455921341Erwinia tasmaniensis, complete genomeNADH dehydrogenase I chain F5e-0652.8
NC_015662:110950:1217191217191230351317Buchnera aphidicola (Cinara tujafilina) chromosome, completeNADH dehydrogenase I subunit F5e-0652.8
NC_017252:155166:1679931679931693271335Buchnera aphidicola str. TLW03 (Acyrthosiphon pisum) chromosome,NADH dehydrogenase I subunit F7e-0652.4
NC_017255:156195:1679971679971693311335Buchnera aphidicola str. LL01 (Acyrthosiphon pisum) chromosome,NADH dehydrogenase I subunit F7e-0652.4
NC_005966:715591:7178977178977192281332Acinetobacter sp. ADP1, complete genomeNADH dehydrogenase I chain F7e-0652.4
NC_008800:1497746:1500922150092215022921371Yersinia enterocolitica subsp. enterocolitica 8081 chromosome,NADH dehydrogenase I subunit F7e-0652.4
NC_017259:148346:1595931595931609421350Buchnera aphidicola str. Ua (Uroleucon ambrosiae) chromosome,NADH dehydrogenase I subunit F7e-0652.4
NC_015224:3191000:3203663320366332050301368Yersinia enterocolitica subsp. palearctica 105.5R(r) chromosome,NADH dehydrogenase I subunit F6e-0652.4
NC_018524:2711817:2725529272552927268571329Nocardiopsis alba ATCC BAA-2165 chromosome, complete genomeNADH oxidoreductase (quinone), F subunit6e-0652.4
NC_002528:148274:1679671679671693011335Buchnera aphidicola str. APS (Acyrthosiphon pisum), completeNADH dehydrogenase I chain F6e-0652.4
NC_011834:156197:1680001680001693341335Buchnera aphidicola str. Tuc7 (Acyrthosiphon pisum) chromosome,NADH dehydrogenase I subunit F7e-0652.4