Pre_GI: BLASTP Hits

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Query: NC_009089:3782000:3792695 Clostridium difficile 630, complete genome

Start: 3792695, End: 3793420, Length: 726

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2761570:278776227877622788487726Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, gamma subunit PrdB, selenocysteine-containing6e-101366
NC_010520:2668702:267593426759342676659726Clostridium botulinum A3 str. Loch Maree, complete genomeD-proline reductase, PrdB subunit6e-101366
NC_010516:2594159:260143826014382602163726Clostridium botulinum B1 str. Okra, complete genomeD-proline reductase, PrdB subunit, selenocysteine-containing8e-101366
NC_010516:2567911:258331925833192584038720Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdB subunit, selenocysteine-containing2e-98358
NC_012563:2761570:276961627696162770335720Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, gamma subunit PrdB, selenocysteine-containing2e-98358
NC_017297:2635892:266234026623402662792453Clostridium botulinum F str. 230613 chromosome, complete genome4e-53207
NC_012658:2641446:265360626536062654052447Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative D-proline reductase, PrdB subunit7e-52203
NC_017297:2635892:264420826442082644654447Clostridium botulinum F str. 230613 chromosome, complete genome1e-51203
NC_017297:2635892:266206726620672662312246Clostridium botulinum F str. 230613 chromosome, complete genome4e-33141
NC_012658:2641446:265333326533332653578246Clostridium botulinum Ba4 str. 657 chromosome, complete genomePrdB protein2e-32139
NC_014330:2026193:2035146203514620364441299Brachyspira pilosicoli 95/1000 chromosome, complete genomeglycine/sarcosine/betaine reductase selenoprotein GrdB8e-1477.4
NC_010718:497222:5021915021915034981308Natranaerobius thermophilus JW/NM-WN-LF, complete genomeselenoprotein B, glycine/betaine/sarcosine/D-proline reductase family1e-1376.6
NC_010516:1382000:1389249138924913905501302Clostridium botulinum B1 str. Okra, complete genomeglycine reductase complex component B, gamma subunit, selenocysteine-containing1e-1273.6
NC_012563:1464000:1471349147134914726501302Clostridium botulinum A2 str. Kyoto, complete genomeglycine reductase, selenoprotein B1e-1273.2
NC_010520:1427981:1435777143577714370781302Clostridium botulinum A3 str. Loch Maree, complete genomeglycine reductase complex component B, gamma subunit, selenocysteine-containing1e-1273.2
NC_014328:3066628:3076704307670430780171314Clostridium ljungdahlii ATCC 49587 chromosome, complete genomebetaine reductase complex component B subunit gamma3e-1168.9
NC_013223:1090397:112428511242851124746462Desulfohalobium retbaense DSM 5692, complete genomehypothetical protein1e-1067
NC_016025:65923:921729217292648477Candidatus Chloracidobacterium thermophilum B chromosome chromosomehypothetical protein2e-0756.6
NC_014328:2990790:3022254302225430235671314Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeglycine reductase complex component B subunit gamma2e-0756.2