Pre_GI: BLASTP Hits

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Query: NC_009089:3782000:3790875 Clostridium difficile 630, complete genome

Start: 3790875, End: 3791357, Length: 483

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3613288:361935936193593619841483Clostridium difficile CD196 chromosome, complete genomehypothetical protein2e-78290
NC_017179:3621306:362737736273773627850474Clostridium difficile BI1, complete genomehypothetical protein2e-76284
NC_017179:3621306:362787736278773628344468Clostridium difficile BI1, complete genomehypothetical protein3e-34144
NC_013315:3613288:361985936198593620326468Clostridium difficile CD196 chromosome, complete genomehypothetical protein3e-34144
NC_009089:3782000:379137537913753791842468Clostridium difficile 630, complete genomehypothetical protein3e-34144
NC_010516:2594159:259983725998372600307471Clostridium botulinum B1 str. Okra, complete genomePrdE protein2e-32138
NC_012658:2641446:266722226672222667692471Clostridium botulinum Ba4 str. 657 chromosome, complete genome3e-32137
NC_009699:2654672:266031626603162660786471Clostridium botulinum F str. Langeland chromosome, complete genomePrdE protein3e-32137
NC_012563:2761570:278616127861612786631471Clostridium botulinum A2 str. Kyoto, complete genome3e-32137
NC_009495:2606238:261179226117922612262471Clostridium botulinum A str. ATCC 3502 chromosome, complete genomePrdE protein3e-32137
NC_009697:2478261:248390524839052484375471Clostridium botulinum A str. ATCC 19397 chromosome, completePrdE protein3e-32137
NC_009698:2450606:245625024562502456720471Clostridium botulinum A str. Hall chromosome, complete genomePrdE protein3e-32137
NC_010520:2668702:267433326743332674803471Clostridium botulinum A3 str. Loch Maree, complete genomePrdE protein2e-31134
NC_014614:2333890:234019623401962340672477Clostridium sticklandii, complete genomeputative uncharacterized protein (PrdE)5e-31133
NC_017297:2635892:266057726605772660936360Clostridium botulinum F str. 230613 chromosome, complete genomePrdA domain protein4e-2097.1
NC_010516:2567911:2584352258435225864662115Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdA proprotein5e-1580.1
NC_009699:2635745:2644821264482126469352115Clostridium botulinum F str. Langeland chromosome, complete genomeD-proline reductase subunit PrdA5e-1580.1
NC_017297:2635892:2644968264496826470822115Clostridium botulinum F str. 230613 chromosome, complete genomeD-proline reductase subunit PrdA5e-1580.1
NC_012563:2761570:2770649277064927727632115Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, PrdA proprotein5e-1580.1
NC_012658:2641446:2654366265436626564802115Clostridium botulinum Ba4 str. 657 chromosome, complete genomeD-proline reductase, PrdA proprotein7e-1579.7
NC_009089:3782000:3793823379382337957031881Clostridium difficile 630, complete genomeproline reductase subunit proprotein1e-1479
NC_013315:3613288:3622307362230736241871881Clostridium difficile CD196 chromosome, complete genomeproline reductase subunit proprotein1e-1479
NC_017179:3621306:3630325363032536322051881Clostridium difficile BI1, complete genomeproline reductase subunit proprotein1e-1479
NC_010520:2668702:2677019267701926791302112Clostridium botulinum A3 str. Loch Maree, complete genomeputative D-proline reductase, PrdA proprotein2e-1478.2
NC_009697:2478261:2486591248659124887022112Clostridium botulinum A str. ATCC 19397 chromosome, completeD-proline reductase subunit PrdA5e-1477
NC_009698:2450606:2458936245893624610472112Clostridium botulinum A str. Hall chromosome, complete genomeD-proline reductase subunit PrdA5e-1477
NC_009495:2606238:2614478261447826165862109Clostridium botulinum A str. ATCC 3502 chromosome, complete genomesubunit of proline reductase5e-1477
NC_012658:2641446:2669909266990926720202112Clostridium botulinum Ba4 str. 657 chromosome, complete genomeD-proline reductase, PrdA proprotein5e-1477
NC_010516:2594159:2602523260252326046312109Clostridium botulinum B1 str. Okra, complete genomeputative D-proline reductase, PrdA proprotein5e-1477
NC_009699:2654672:2663002266300226651102109Clostridium botulinum F str. Langeland chromosome, complete genomeD-proline reductase subunit PrdA5e-1477
NC_017297:2635892:2663152266315226652602109Clostridium botulinum F str. 230613 chromosome, complete genomeputative D-proline reductase, PrdA proprotein5e-1477
NC_012563:2761570:2788847278884727909552109Clostridium botulinum A2 str. Kyoto, complete genomeD-proline reductase, PrdA proprotein4e-1477
NC_014614:2333890:2342523234252323444121890Clostridium sticklandii, complete genomeD-proline reductase proprotein prdA [Contains: D-proline reductase subunit beta (D-proline reductase 45 kDa subunit); D-proline reductase subunit alph1e-1375.5