Pre_GI: BLASTP Hits

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Query: NC_009089:3782000:3789848 Clostridium difficile 630, complete genome

Start: 3789848, End: 3790855, Length: 1008

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:3621306:3626350362635036273571008Clostridium difficile BI1, complete genomeproline racemase0654
NC_013315:3613288:3618332361833236193391008Clostridium difficile CD196 chromosome, complete genomeproline racemase0654
NC_014614:2333890:2339192233919223401991008Clostridium sticklandii, complete genomeProline racemase A precursor (TcPRACA) (TcPA45-A) (rTcPA45)1e-132473
NC_010516:2594159:2598816259881625998231008Clostridium botulinum B1 str. Okra, complete genomeproline racemase2e-117422
NC_012563:2761570:2785140278514027861471008Clostridium botulinum A2 str. Kyoto, complete genomeproline racemase2e-117422
NC_010520:2668702:2673312267331226743191008Clostridium botulinum A3 str. Loch Maree, complete genomeproline racemase2e-117422
NC_009495:2606238:2610771261077126117781008Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeproline racemase2e-117422
NC_009697:2478261:2482884248288424838911008Clostridium botulinum A str. ATCC 19397 chromosome, completeproline racemase2e-117422
NC_009698:2450606:2455229245522924562361008Clostridium botulinum A str. Hall chromosome, complete genomeproline racemase2e-117422
NC_009699:2654672:2659294265929426603011008Clostridium botulinum F str. Langeland chromosome, complete genomeproline racemase2e-117422
NC_017297:2635892:2659443265944326604501008Clostridium botulinum F str. 230613 chromosome, complete genomeproline racemase2e-117422
NC_012658:2641446:2666201266620126672081008Clostridium botulinum Ba4 str. 657 chromosome, complete genomeproline racemase2e-117422
NC_016641:2773757:2782839278283927838401002Paenibacillus terrae HPL-003 chromosome, complete genomeproline racemase6e-86317
NC_011883:2031222:2034668203466820356751008Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774,proline racemase9e-80297
NC_013524:1207845:1226906122690612279071002Sphaerobacter thermophilus DSM 20745 chromosome 2, complete genomeProline racemase4e-77288
NC_008148:2231045:2270834227083422718471014Rubrobacter xylanophilus DSM 9941, complete genomeproline racemase4e-76285
NC_014815:4621552:4653973465397346549741002Micromonospora sp. L5 chromosome, complete genomeproline racemase5e-75281
NC_013947:4363250:4381353438135343823541002Stackebrandtia nassauensis DSM 44728 chromosome, complete genomeProline racemase2e-72272
NC_014934:4834000:4835848483584848368551008Cellulophaga algicola DSM 14237 chromosome, complete genomeproline racemase1e-68260
NC_010170:1324758:132581013258101326808999Bordetella petrii, complete genomehypothetical protein5e-68258
NC_008148:2231045:2259325225932522603321008Rubrobacter xylanophilus DSM 9941, complete genomeproline racemase7e-67254
NC_016745:546249:5491605491605501611002Oceanimonas sp. GK1 chromosome, complete genomehydroxyproline-2-epimerase5e-66251
NC_003305:1035342:105673110567311057729999Agrobacterium tumefaciens str. C58 chromosome linear, completehypothetical protein2e-61236
NC_016002:2652500:2654016265401626550801065Pseudogulbenkiania sp. NH8B, complete genomeproline racemase1e-60233
NC_015379:4426827:443879244387924439715924Pseudomonas brassicacearum subsp. brassicacearum NFM421 chromosome,4-hydroxyproline epimerase9e-55214
NC_012483:3731542:379978937997893800736948Acidobacterium capsulatum ATCC 51196, complete genomeputative proline racemase5e-50198
NC_016642:1913432:1923747192374719247721026Pseudovibrio sp. FO-BEG1 chromosome, complete genomeproline racemase7e-50197
NC_020064:1854589:185364218536421854592951Serratia marcescens FGI94, complete genomeproline racemase4e-49195
NC_007802:1484641:1498924149892414999641041Jannaschia sp. CCS1, complete genomeproline racemase2e-48192
NC_020829:809457:812039812039812983945Pseudomonas denitrificans ATCC 13867, complete genomeproline racemase3e-48192
NC_011894:4013830:403950240395024040473972Methylobacterium nodulans ORS 2060, complete genomeproline racemase8e-48191
NC_010511:4258000:427531442753144276285972Methylobacterium sp. 4-46 chromosome, complete genomeproline racemase3e-46186
NC_011894:4013830:404885040488504049818969Methylobacterium nodulans ORS 2060, complete genomeproline racemase6e-42171
NC_017506:923500:9359189359189369791062Marinobacter adhaerens HP15 chromosome, complete genomeproline racemase7e-38158
NC_014166:1179335:1184831118483111858681038Arcobacter nitrofigilis DSM 7299 chromosome, complete genomeproline racemase3e-33142
NC_014841:131308:1482791482791493431065Pantoea sp. At-9b plasmid pPAT9B04, complete sequenceProline racemase6e-27121