Pre_GI: BLASTP Hits

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Query: NC_009089:3782000:3788847 Clostridium difficile 630, complete genome

Start: 3788847, End: 3789728, Length: 882

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:3621306:362534936253493626230882Clostridium difficile BI1, complete genomehypothetical protein8e-155546
NC_013315:3613288:361733136173313618212882Clostridium difficile CD196 chromosome, complete genomehypothetical protein8e-155546
NC_014614:2333890:233825323382532339128876Clostridium sticklandii, complete genomeconserved membrane protein of unknown function (PrdG)2e-84312
NC_010520:2668702:267190226719022672789888Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein6e-84310
NC_010516:2594159:259735925973592598246888Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-82306
NC_012563:2761570:278372327837232784610888Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-82306
NC_009699:2654672:265790026579002658769870Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-82305
NC_017297:2635892:265804926580492658918870Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-82305
NC_012658:2641446:266481226648122665681870Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein5e-82304
NC_009495:2606238:260946726094672610336870Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-81302
NC_009698:2450606:245383524538352454704870Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein4e-81301
NC_009697:2478261:248149024814902482359870Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein4e-81301
NC_010516:2567911:258207425820742582952879Clostridium botulinum B1 str. Okra, complete genomehypothetical protein1e-78293
NC_009495:2571732:259384725938472594725879Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein1e-78293
NC_017297:2635892:264269026426902643568879Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein3e-78291
NC_009699:2635745:264254326425432643421879Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein3e-78291
NC_012563:2761570:276837127683712769249879Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-78291
NC_012658:2641446:265208826520882652966879Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein3e-78291
NC_012563:2761570:277510327751032775999897Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-75282
NC_009699:2635745:264927226492722650168897Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-75282
NC_017297:2635892:264942026494202650316897Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-75282
NC_012658:2641446:265871326587132659609897Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein8e-75280
NC_007929:1290568:131107413110741311940867Lactobacillus salivarius subsp. salivarius UCC118, complete genomeHypothetical membrane spanning protein2e-38159
NC_014334:369974:376997376997377866870Lactobacillus casei str. Zhang chromosome, complete genomehypothetical protein5e-34144
NC_010999:349252:353723353723354592870Lactobacillus casei, complete genomeHypothetical integral membrane protein5e-34144