Pre_GI: BLASTP Hits

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Query: NC_009089:3782000:3783072 Clostridium difficile 630, complete genome

Start: 3783072, End: 3784355, Length: 1284

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:2012500:2023850202385020251421293Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein5e-79295
NC_009697:2012500:2023633202363320249251293Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-79295
NC_009495:2085000:2094992209499220962841293Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-79295
NC_017297:2143000:2153431215343121547231293Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein4e-78291
NC_009699:2142177:2153332215333221546241293Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-78291
NC_010516:2093901:2103098210309821043901293Clostridium botulinum B1 str. Okra, complete genomehypothetical protein4e-78291
NC_012563:2230403:2241701224170122429901290Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-78291
NC_012658:2138791:2149723214972321510121290Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein8e-78291
NC_018515:4196409:4206266420626642075731308Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein5e-75281
NC_018870:2479114:2486924248692424882431320Thermacetogenium phaeum DSM 12270 chromosome, complete genomeserine dehydratase-like, subunit alpha6e-74278
NC_014933:3942156:3962382396238239636651284Bacteroides helcogenes P 36-108 chromosome, complete genomeinner membrane protein1e-71270
NC_015311:365007:3802283802283815171290Prevotella denticola F0289 chromosome, complete genomehypothetical protein7e-66251
NC_014618:586240:6143916143916157011311Enterobacter cloacae SCF1 chromosome, complete genomehypothetical protein1e-64247
NC_008262:904000:9168959168959181781284Clostridium perfringens SM101, complete genomehypothetical protein3e-62239
NC_013941:3884725:3884725388472538860351311Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein3e-62239
NC_002695:3994970:3994970399497039962801311Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein3e-62239
NC_011415:3523364:3523364352336435246741311Escherichia coli SE11 chromosome, complete genomehypothetical protein8e-62238
CU928145:3608917:3608917360891736102271311Escherichia coli 55989 chromosome, complete genomeconserved hypothetical protein8e-62238
NC_011748:3608917:3608917360891736102271311Escherichia coli 55989, complete genomehypothetical protein8e-62238
NC_003366:981105:9901919901919914741284Clostridium perfringens str. 13, complete genomehypothetical protein2e-61236
NC_010658:3014371:3031259303125930325691311Shigella boydii CDC 3083-94, complete genomehypothetical protein3e-61236
NC_012947:630757:6508556508556521651311Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypothetical protein3e-61236
NC_011750:3768692:3768692376869237700021311Escherichia coli IAI39 chromosome, complete genomehypothetical protein3e-61236
NC_011751:3710786:3710786371078637120961311Escherichia coli UMN026 chromosome, complete genomehypothetical protein4e-61235
NC_014364:2904443:2907783290778329090841302Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeprotein of unknown function DUF10634e-61235
NC_021066:3703725:3711465371146537127751311Raoultella ornithinolytica B6, complete genomehypothetical protein5e-60232
NC_016077:2044876:2048537204853720498771341Acidaminococcus intestini RyC-MR95 chromosome, complete genomehypothetical protein1e-57224
NC_012779:2957000:2971262297126229725571296Edwardsiella ictaluri 93-146, complete genomehypothetical protein1e-55217
NC_015873:380485:4054994054994068181320Megasphaera elsdenii DSM 20460, complete genomeUPF0597 protein HMPREF0889_14066e-54211
NC_012785:638000:6431456431456444131269Kosmotoga olearia TBF 19.5.1, complete genomeprotein of unknown function DUF10632e-53210
NC_016048:4163225:4166769416676941680461278Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein2e-45183
NC_016630:1610723:1621430162143016226651236Filifactor alocis ATCC 35896 chromosome, complete genomeinner membrane protein1e-41171
NC_015500:159199:1626371626371639261290Treponema brennaborense DSM 12168 chromosome, complete genomeUPF0597 protein yhaM2e-30134