Pre_GI: BLASTP Hits

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Query: NC_009089:3782000:3782205 Clostridium difficile 630, complete genome

Start: 3782205, End: 3782744, Length: 540

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007907:4500000:450620445062044506749546Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-45181
NC_011830:1504497:153400415340041534549546Desulfitobacterium hafniense DCB-2, complete genomehypoxanthine phosphoribosyltransferase2e-45181
NC_008095:6323456:634646263464626346995534Myxococcus xanthus DK 1622, complete genomehypoxanthine phosphoribosyltransferase3e-43174
NC_015711:8169752:820841282084128208945534Myxococcus fulvus HW-1 chromosome, complete genomehypoxanthine phosphoribosyltransferase2e-42171
NC_010320:819326:824984824984825529546Thermoanaerobacter sp. X514 chromosome, complete genomehypoxanthine phosphoribosyltransferase2e-42171
NC_015958:2361551:237722723772272377772546Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehypoxanthine phosphoribosyltransferase2e-42171
NC_008593:153014:156942156942157481540Clostridium novyi NT, complete genomehypoxanthine phosphoribosyltransferase3e-42171
NC_020291:117983:134509134509135048540Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypoxanthine phosphoribosyltransferase Hpt2e-41168
NC_009495:3735703:376943137694313769976546Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypoxanthine phosphoribosyltransferase2e-41168
NC_009698:3609881:364253036425303643075546Clostridium botulinum A str. Hall chromosome, complete genomehypoxanthine phosphoribosyltransferase2e-41168
NC_009699:3839575:387221838722183872763546Clostridium botulinum F str. Langeland chromosome, complete genomehypoxanthine phosphoribosyltransferase2e-41168
NC_017243:3141500:315609931560993156629531Brachyspira intermedia PWS/A chromosome, complete genomehypoxanthine-guanine phosphoribosyltransferase9e-41166
NC_018604:2579000:263027826302782630802525Brachyspira pilosicoli WesB complete genomehypoxanthine-guanine phosphoribosyltransferase7e-41166
NC_018607:290500:292176292176292700525Brachyspira pilosicoli B2904 chromosome, complete genomehypoxanthine-guanine phosphoribosyltransferase7e-41166
NC_014330:1113145:114893011489301149454525Brachyspira pilosicoli 95/1000 chromosome, complete genomehypoxanthine-guanine phosphoribosyltransferase7e-41166
NC_008262:2649289:269325626932562693807552Clostridium perfringens SM101, complete genomehypoxanthine phosphoribosyltransferase7e-41166
NC_004557:162670:164060164060164605546Clostridium tetani E88, complete genomehypoxanthine-guanine phosphoribosyltransferase1e-40165
NC_010723:173280:182612182612183151540Clostridium botulinum E3 str. Alaska E43, complete genomehypoxanthine phosphoribosyltransferase3e-40164
NC_015425:163000:167030167030167569540Clostridium botulinum BKT015925 chromosome, complete genomehypoxanthine phosphoribosyltransferase6e-40163
NC_016818:3986570:399778039977803998316537Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completehypoxanthine phosphoribosyltransferase1e-39162
NC_017208:64500:687426874269284543Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypoxanthine-guanine phosphoribosyltransferase7e-40162
NC_018664:2459994:248409624840962484632537Clostridium acidurici 9a chromosome, complete genomehypoxanthine phosphoribosyltransferase Hpt2e-39161
NC_007929:1397989:141815414181541418693540Lactobacillus salivarius subsp. salivarius UCC118, complete genomeHypoxanthine-guanine phosphoribosyltransferase4e-39160
NC_009655:866281:871113871113871649537Actinobacillus succinogenes 130Z chromosome, complete genomehypoxanthine phosphoribosyltransferase5e-39160
NC_001263:1378605:138380013838001384330531Deinococcus radiodurans R1 chromosome 1, complete sequencehypoxanthine-guanine phosphoribosyltransferase3e-38157
NC_014758:1489761:150959315095931510126534Calditerrivibrio nitroreducens DSM 19672 chromosome, completehypoxanthine phosphoribosyltransferase4e-38157
NC_012121:139741:163683163683164228546Staphylococcus carnosus subsp. carnosus TM300, complete genomeputative hypoxanthine-guanine phosphoribosyltransferase2e-37155
NC_013939:1023443:102759810275981028131534Deferribacter desulfuricans SSM1, complete genomehypoxanthine phosphoribosyltransferase9e-38155
NC_012947:3619384:363895136389513639499549Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completehypoxanthine phosphoribosyltransferase2e-37154
NC_010468:3835259:385761638576163858164549Escherichia coli ATCC 8739, complete genomehypoxanthine phosphoribosyltransferase2e-37154
NC_014314:755166:759607759607760176570Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completehypoxanthine phosphoribosyltransferase1e-36152
NC_009092:3732390:373574937357493736279531Shewanella loihica PV-4, complete genomehypoxanthine phosphoribosyltransferase1e-36152
NC_004668:241352:241352241352241897546Enterococcus faecalis V583, complete genomehypoxanthine-guanine phosphoribosyltransferase7e-37152
NC_017316:203233:206316206316206861546Enterococcus faecalis OG1RF chromosome, complete genomehypoxanthine phosphoribosyltransferase7e-37152
NC_009012:2661795:268243526824352682989555Clostridium thermocellum ATCC 27405, complete genomehypoxanthine phosphoribosyltransferase2e-36151
NC_014221:1518583:153433115343311534915585Truepera radiovictrix DSM 17093 chromosome, complete genomehypoxanthine phosphoribosyltransferase2e-36151
NC_013515:347671:388701388701389237537Streptobacillus moniliformis DSM 12112, complete genomehypoxanthine phosphoribosyltransferase3e-36150
NC_014328:4471995:449740244974024497947546Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypoxanthine-guanine phosphoribosyltransferase3e-36150
NC_014151:657382:672630672630673184555Cellulomonas flavigena DSM 20109 chromosome, complete genomehypoxanthine phosphoribosyltransferase2e-35148
NC_011999:2023248:203905820390582039597540Macrococcus caseolyticus JCSC5402, complete genomehypoxanthine phosphoribosyltransferase2e-35148
NC_018704:81733:831478314783689543Amphibacillus xylanus NBRC 15112, complete genomehypoxanthine-guanine phosphoribosyltransferase4e-35147
NC_015978:412856:415510415510416052543Lactobacillus sanfranciscensis TMW 1.1304 chromosome, completehypothetical protein5e-35146
NC_008497:556365:557734557734558276543Lactobacillus brevis ATCC 367, complete genomeHypoxanthine-guanine phosphoribosyltransferase1e-34145
NC_016605:272231:275173275173275709537Pediococcus claussenii ATCC BAA-344 chromosome, complete genomehypoxanthine phosphoribosyltransferase5e-34143
NC_008525:1493317:151420415142041514740537Pediococcus pentosaceus ATCC 25745, complete genomeHypoxanthine-guanine phosphoribosyltransferase5e-34143
NC_014972:322056:322056322056322574519Desulfobulbus propionicus DSM 2032 chromosome, complete genomehypoxanthine phosphoribosyltransferase6e-34143
NC_009513:303043:304430304430304972543Lactobacillus reuteri F275, complete genomehypoxanthine phosphoribosyltransferase1e-33142
NC_017095:2143845:214384521438452144366522Fervidobacterium pennivorans DSM 9078 chromosome, complete genomehypoxanthine phosphoribosyltransferase3e-33141
NC_013928:9494:121301213012672543Streptococcus mutans NN2025, complete genomehypoxanthine-guanine phosphoribosyltransferase1e-32139
NC_006448:5046:121351213512677543Streptococcus thermophilus LMG 18311, complete genomehypoxanthine-guanine phosphoribosyltransferase4e-32137
NC_006449:5046:121351213512677543Streptococcus thermophilus CNRZ1066, complete genomehypoxanthine-guanine phosphoribosyltransferase4e-32137
NC_006085:308567:312708312708313262555Propionibacterium acnes KPA171202, complete genomeputative hypoxanthine phosphoribosyltransferase3e-32137
NC_014039:334892:339033339033339587555Propionibacterium acnes SK137 chromosome, complete genomehypoxanthine phosphoribosyltransferase3e-32137
NC_016511:308244:312385312385312939555Propionibacterium acnes TypeIA2 P.acn31 chromosome, completehypoxanthine phosphoribosyltransferase3e-32137
NC_016512:305240:311749311749312303555Propionibacterium acnes TypeIA2 P.acn17 chromosome, completehypoxanthine phosphoribosyltransferase3e-32137
NC_016516:300846:303182303182303736555Propionibacterium acnes TypeIA2 P.acn33 chromosome, completehypoxanthine phosphoribosyltransferase3e-32137
NC_015930:18969:202152021520754540Lactococcus garvieae ATCC 49156, complete genomehypoxanthine phosphoribosyltransferase8e-32136
NC_015587:215433:218949218949219452504Hydrogenobaculum sp. SHO chromosome, complete genomehypoxanthine phosphoribosyltransferase4e-31134
NC_015557:215397:218913218913219416504Hydrogenobaculum sp. 3684 chromosome, complete genomehypoxanthine phosphoribosyltransferase4e-31134
NC_020411:215432:218948218948219451504Hydrogenobaculum sp. HO, complete genomehypoxanthine phosphoribosyltransferase4e-31134
NC_011126:219379:221582221582222085504Hydrogenobaculum sp. Y04AAS1, complete genomehypoxanthine phosphoribosyltransferase6e-31133
NC_017093:8407968:842988684298868430461576Actinoplanes missouriensis 431, complete genomeputative hypoxanthine phosphoribosyltransferase1e-30132
NC_004432:1310322:134059613405961341129534Mycoplasma penetrans HF-2, complete genomehypoxanthine-guanine phosphoribosyltransferase2e-28125
NC_007633:253143:259671259671260243573Mycoplasma capricolum subsp. capricolum ATCC 27343, completehypoxanthine phosphoribosyltransferase3e-28124
NC_015760:8914:120521205212594543Streptococcus salivarius CCHSS3, complete genomehypoxanthine-guanine phosphoribosyltransferase8e-27119
NC_015510:4065753:406575340657534066286534Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomehypoxanthine phosphoribosyltransferase7e-25113
NC_011565:620801:653768653768654319552Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,hypoxanthine phosphoribosyltransferase5e-22103
NC_014751:302152:307896307896308468573Mycoplasma leachii PG50 chromosome, complete genomehypoxanthine phosphoribosyltransferase1e-21102
NC_015276:2852010:285201028520102852567558Marinomonas mediterranea MMB-1 chromosome, complete genomephosphoribosyltransferase2e-21102
NC_009434:3413461:342211134221113422668558Pseudomonas stutzeri A1501, complete genomehypoxanthine-guanine phosphoribosyltransferase4e-21100
NC_014738:55782:778277782778402576Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,hypoxanthine phosphoribosyltransferase4e-1994
NC_006513:1949751:196886819688681969425558Azoarcus sp. EbN1, complete genomehypoxanthine-guanine phosphoribosyltransferase1e-1685.9
NC_010995:4525119:453365045336504534192543Cellvibrio japonicus Ueda107, complete genomeputative hypoxanthine phosphoribosyltransferase3e-1684.7
NC_011761:292903:311727311727312311585Acidithiobacillus ferrooxidans ATCC 23270 chromosome, completehypoxanthine-guanine phosphoribosyltransferase9e-1579.7
NC_016628:1:187751877519308534Vibrio furnissii NCTC 11218 chromosome 2, complete sequencehypoxanthine-guanine phosphoribosyltransferase2e-1375.1
NC_010804:450130:476098476098476649552Burkholderia multivorans ATCC 17616 chromosome 1, completehypoxanthine phosphoribosyltransferase2e-1375.1
NC_007347:3204637:323430932343093234851543Ralstonia eutropha JMP134 chromosome 1, complete sequencehypoxanthine-guanine phosphoribosyltransferase4e-1374.3
NC_008576:777949:798274798274798846573Magnetococcus sp. MC-1, complete genomephosphoribosyltransferase2e-1272
NC_012968:1108687:113090211309021131444543Methylotenera mobilis JLW8, complete genomephosphoribosyltransferase3e-1271.2
NC_012997:2107933:212044421204442120905462Teredinibacter turnerae T7901, complete genomeputative hypoxanthine-guanine phosphoribosyltransferase1e-1066.2
NC_015968:2110175:211713421171342117658525Enterobacter asburiae LF7a chromosome, complete genomephosphoribosyltransferase3e-0961.6
NC_019791:1272850:128203012820301282791762Caldisphaera lagunensis DSM 15908 chromosome, complete genomephosphoribosyltransferase2e-0652