Pre_GI: BLASTP Hits

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Query: NC_009089:3241918:3258702 Clostridium difficile 630, complete genome

Start: 3258702, End: 3260588, Length: 1887

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:3082000:3095874309587430977541881Clostridium difficile BI1, complete genomecell surface protein01140
NC_013315:3073652:3087922308792230898021881Clostridium difficile CD196 chromosome, complete genomecell surface protein01140
NC_013316:1081044:1093266109326610953052040Clostridium difficile R20291, complete genomecell surface protein (putative N-acetylmuramoyl-L-alanine amidase)2e-65251
NC_009089:1202261:1217070121707012191032034Clostridium difficile 630, complete genomecell surface protein (putative N-acetylmuramoyl-L-alanine amidase)2e-65250
NC_013316:1081044:1095797109579710978302034Clostridium difficile R20291, complete genomecell surface protein (putative N-acetylmuramoyl-L-alanine amidase)2e-65250
NC_009089:1202261:1214547121454712165862040Clostridium difficile 630, complete genomecell surface protein (putative N-acetylmuramoyl-L-alanine amidase)2e-65250
NC_009089:3241918:3241918324191832443292412Clostridium difficile 630, complete genomecell surface protein (putative cell surface-associated cysteine protease)1e-54214
NC_009089:3241918:3245004324500432468361833Clostridium difficile 630, complete genomecell surface protein1e-53211
NC_017179:3082000:3082047308204730838821836Clostridium difficile BI1, complete genomecell surface protein2e-52207
NC_013315:3073652:3074095307409530759301836Clostridium difficile CD196 chromosome, complete genomecell surface protein2e-52207
NC_013315:1707293:1727689172768917300882400Clostridium difficile CD196 chromosome, complete genomepenicillin-binding protein3e-50200
NC_017177:91993:1253731253731267491377Clostridium difficile BI1, complete genomehemagglutinin/adhesin1e-41171
NC_014328:2426921:2436213243621324391222910Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein1e-40168
NC_014328:2426921:2442291244229124442551965Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein1e-40168
NC_014328:2426921:2430181243018124320701890Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein2e-37157
NC_014328:938393:9539089539089561212214Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein4e-36153
NC_009706:2925000:2942035294203529435131479Clostridium kluyveri DSM 555 chromosome, complete genomecell wall binding protein1e-35151
NC_011837:2856500:2873537287353728750391503Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-35151
NC_016584:5388500:5392334539233453949882655Desulfosporosinus orientis DSM 765 chromosome, complete genomecell wall-binding protein9e-35149
NC_009089:3241918:3252559325255932547182160Clostridium difficile 630, complete genomecell surface protein (S-layer precursor protein)9e-35149
NC_015172:1075592:1095774109577411005974824Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomecell wall binding repeat 2-containing protein4e-33143
NC_011830:4722607:4749674474967447513861713Desulfitobacterium hafniense DCB-2, complete genomeIg domain protein group 2 domain protein4e-32140
NC_007907:5104476:5125684512568451277202037Desulfitobacterium hafniense Y51, complete genomehypothetical protein7e-32139
NC_009089:3241918:3247683324768332495541872Clostridium difficile 630, complete genomecell surface protein (putative S-layer protein precursor)1e-31138
NC_013315:3073652:3076777307677730786481872Clostridium difficile CD196 chromosome, complete genomeS-layer protein2e-31137
NC_017179:3082000:3084729308472930866001872Clostridium difficile BI1, complete genomeS-layer protein2e-31137
NC_013315:3073652:3085954308595430875551602Clostridium difficile CD196 chromosome, complete genomecell surface protein6e-31136
NC_017179:3082000:3093906309390630955011596Clostridium difficile BI1, complete genomecell surface protein6e-31136
NC_007907:3722500:3752354375235437540301677Desulfitobacterium hafniense Y51, complete genomehypothetical protein5e-31136
NC_010376:49185:6033260332680177686Finegoldia magna ATCC 29328, complete genomeputative N-acetylmuramoyl-L-alanine amidase5e-31136
NC_010376:186510:1934951934951954681974Finegoldia magna ATCC 29328, complete genomeputative N-acetylmuramoyl-L-alanine amidase5e-31136
NC_007907:2995889:3013521301352130148401320Desulfitobacterium hafniense Y51, complete genomehypothetical protein8e-31135
NC_014328:1108479:1114075111407511163602286Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative surface-layer protein9e-31135
NC_018515:4334240:4356270435627043588942625Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall-binding protein1e-30135
NC_009089:3241918:3256734325673432583351602Clostridium difficile 630, complete genomecell surface protein3e-30134
NC_009089:3241918:3254929325492932565151587Clostridium difficile 630, complete genomesurface surface protein2e-30134
NC_015172:2986867:3028296302829630304672172Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomecell wall binding repeat 2-containing protein1e-30134
NC_013315:3073652:3084146308414630857351590Clostridium difficile CD196 chromosome, complete genomesurface protein1e-30134
NC_017179:3082000:3092098309209830936871590Clostridium difficile BI1, complete genomesurface protein1e-30134
NC_011830:4722607:4758940475894047613272388Desulfitobacterium hafniense DCB-2, complete genomeputative cell wall binding repeat 2-containing protein6e-30132
NC_015520:2567329:2581460258146025833461887Mahella australiensis 50-1 BON chromosome, complete genometransglutaminase domain-containing protein2e-29130
NC_015520:224136:2438912438912469293039Mahella australiensis 50-1 BON chromosome, complete genomecell wall binding repeat 2-containing protein3e-29130
NC_007907:3722500:3756571375657137589492379Desulfitobacterium hafniense Y51, complete genomehypothetical protein7e-29129
NC_016584:5420823:5427391542739154290761686Desulfosporosinus orientis DSM 765 chromosome, complete genomecell wall-binding protein6e-29129
NC_016584:3847663:3863026386302638676574632Desulfosporosinus orientis DSM 765 chromosome, complete genomecell wall-binding protein5e-29129
NC_010376:28812:3102331023369055883Finegoldia magna ATCC 29328, complete genomecell wall-associated serine proteinase precursor3e-28127
NC_011830:4722607:4756991475699147589041914Desulfitobacterium hafniense DCB-2, complete genomeIg domain protein4e-28126
NC_010376:28812:3724337243419074665Finegoldia magna ATCC 29328, complete genomeN-acetylmuramoyl-L-alanine amidase5e-27123
NC_011830:4399642:440620144062014407181981Desulfitobacterium hafniense DCB-2, complete genomeputative cell wall binding repeat 2-containing protein7e-27122
NC_013315:3073652:3081644308164430839202277Clostridium difficile CD196 chromosome, complete genomeS-layer protein4e-26120
NC_017179:3082000:3089596308959630918722277Clostridium difficile BI1, complete genomeS-layer precursor protein4e-26120
NC_015172:1471501:14866231486623149964213020Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomecell wall binding repeat 2-containing protein4e-26120
NC_000964:3658000:3658149365814936596391491Bacillus subtilis subsp. subtilis str. 168, complete genomeN-acetylmuramoyl-L-alanine amidase (major autolysin) (CWBP49)3e-26120
NC_011830:3528665:3530497353049735326172121Desulfitobacterium hafniense DCB-2, complete genomeputative cell wall binding repeat 2-containing protein8e-26119
NC_015520:224136:2513782513782550163639Mahella australiensis 50-1 BON chromosome, complete genomepeptidase S8 and S53 subtilisin kexin sedolisin3e-25117
NC_015172:2986867:3032883303288330365513669Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomecell wall binding repeat 2-containing protein8e-25115
NC_018515:4474000:4494291449429144985144224Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall-binding protein1e-24115
NC_009698:2265475:2286166228616622877821617Clostridium botulinum A str. Hall chromosome, complete genomeamidase3e-24113
NC_006322:3628143:3628143362814336302872145Bacillus licheniformis ATCC 14580, complete genomeLytB8e-24112
NC_006270:3627974:3627974362797436301182145Bacillus licheniformis ATCC 14580, complete genomemodifier protein of major autolysin LytC (CWBP76)8e-24112
NC_007907:2249607:2251795225179522543742580Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-23112
NC_016584:1436710:1446961144696114515414581Desulfosporosinus orientis DSM 765 chromosome, complete genomegluconolactonase3e-23110
NC_018515:595500:6120286120286152403213Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall-binding protein5e-23109
NC_009664:452195:4521954521954539971803Kineococcus radiotolerans SRS30216, complete genomeputative cell wall binding repeat 2-containing protein7e-22106
NC_014246:611275:61127561127562342112147Mobiluncus curtisii ATCC 43063 chromosome, complete genomebacterial Ig-like domain-containing protein7e-21102
NC_015520:1683616:1690889169088917007769888Mahella australiensis 50-1 BON chromosome, complete genomeIg family protein1e-20102
NC_000964:3658000:3659678365967836617952118Bacillus subtilis subsp. subtilis str. 168, complete genomemodifier protein of major autolysin LytC (CWBP76)2e-20101
NC_014328:522045:5416295416295431881560Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein2e-20101
NC_017195:3459567:3459567345956734616842118Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeputative cell wall binding repeat 2 family2e-20101
NC_011837:3052000:3056664305666430599813318Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-20101
NC_018515:1406816:1421052142105214269855934Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein1e-20101
NC_018866:108812:1241191241191256331515Dehalobacter sp. DCA chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase4e-20100
NC_018867:179975:1917141917141932281515Dehalobacter sp. CF chromosome, complete genomehypothetical protein4e-20100
NC_007907:2249607:2257635225763522635325898Desulfitobacterium hafniense Y51, complete genomehypothetical protein4e-20100
NC_014328:3336000:3349827334982733513021476Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein5e-20100
NC_010376:1711182:1722867172286717242971431Finegoldia magna ATCC 29328, complete genomeN-acetylmuramoyl-L-alanine amidase1e-1998.6
NC_014328:3294086:3295757329575732967911035Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein1e-1998.6
NC_007907:3722500:3759012375901237609401929Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-1998.2
NC_014328:522045:5382445382445415763333Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative surface-layer protein4e-1997.1
NC_014169:2234249:2246905224690522489532049Bifidobacterium longum subsp. longum JDM301 chromosome, completehypothetical protein4e-1996.7
NC_018515:1406816:1414764141476414208416078Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein6e-1996.3
NC_004557:691944:7116347116347131511518Clostridium tetani E88, complete genomeputative S-layer protein/internalin A-like/N-acetylmuramoyl-L-alanine amidase2e-1894.7
NC_011837:3052000:3055001305500130565571557Clostridium kluyveri NBRC 12016, complete genomehypothetical protein3e-1894
NC_004557:806878:8130058130058150082004Clostridium tetani E88, complete genomeN-acetylmuramoyl-L-alanine amidase6e-1892.8
NC_004557:806878:8150588150588161191062Clostridium tetani E88, complete genomeinternalin-like/N-acetylmuramoyl-L-alanine amidase9e-1892.4
NC_011830:4722607:4761677476167747650843408Desulfitobacterium hafniense DCB-2, complete genomeputative cell wall binding repeat 2-containing protein6e-1789.7
NC_018515:595500:6153216153216173332013Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall-binding protein3e-1687
NC_009664:3969609:3988523398852339899501428Kineococcus radiotolerans SRS30216, complete genomeputative cell wall binding repeat 2-containing protein3e-1584
NC_018515:4442500:4457444445744444590811638Desulfosporosinus meridiei DSM 13257 chromosome, complete genomecell wall-binding protein7e-1582.8
NC_014830:335380:3522053522053539561752Intrasporangium calvum DSM 43043 chromosome, complete genomeDomain of unknown function DUF19944e-1480.5
NC_009664:4696961:4744702474470247468612160Kineococcus radiotolerans SRS30216, complete genomeputative cell wall binding repeat 2-containing protein6e-1479.7
NC_009697:419443:4275024275024285901089Clostridium botulinum A str. ATCC 19397 chromosome, completeamidase2e-1377.8
NC_010418:188138:1983021983021993901089Clostridium botulinum A3 str. Loch Maree plasmid pCLK, completeamidase domain protein6e-1376.3
NC_004557:455895:4601364601364633783243Clostridium tetani E88, complete genomeputative S-layer protein/N-acetylmuramoyl-L-alanine amidase4e-1273.9
NC_015738:978794:1019913101991310217751863Eggerthella sp. YY7918, complete genomepolysaccharide ABC transporter2e-1171.6
NC_014328:3823902:3831411383141138378246414Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative cell wall-binding protein2e-1171.2
NC_014246:876000:8838518838518856891839Mobiluncus curtisii ATCC 43063 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase family protein1e-0965.1
NC_009635:905768:9154509154509165891140Methanococcus aeolicus Nankai-3 chromosome, complete genomecell wall binding repeat 2-containing protein1e-0758.9
NC_000868:1386592:1389242138924213902431002Pyrococcus abyssi GE5, complete genomehypothetical protein9e-0652.4