Pre_GI: BLASTP Hits

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Query: NC_009089:3241918:3249969 Clostridium difficile 630, complete genome

Start: 3249969, End: 3252314, Length: 2346

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:3082000:3087015308701530893602346Clostridium difficile BI1, complete genomepreprotein translocase subunit SecA01477
NC_013315:3073652:3079063307906330814082346Clostridium difficile CD196 chromosome, complete genomepreprotein translocase SecA subunit01477
NC_019970:2190695:2205441220544122081252685Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepreprotein translocase, SecA subunit0860
NC_014410:2149886:2161631216163121643182688Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,preprotein translocase, SecA subunit0859
NC_009922:2672396:2688981268898126916532673Alkaliphilus oremlandii OhILAs, complete genomepreprotein translocase, SecA subunit0853
NC_015555:693461:7002777002777029612685Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeProtein translocase subunit secA0851
NC_010718:2337209:2353829235382923564892661Natranaerobius thermophilus JW/NM-WN-LF, complete genomeprotein translocase subunit secA0840
NC_013205:2610956:2631243263124326336332391Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,preprotein translocase, SecA subunit0833
NC_011898:1762000:1768751176875117714892739Clostridium cellulolyticum H10, complete genomepreprotein translocase, SecA subunit0832
NC_019897:128610:1940631940631965822520Thermobacillus composti KWC4 chromosome, complete genomePreprotein translocase subunit SecA0830
NC_009437:1481064:1491520149152014940662547Caldicellulosiruptor saccharolyticus DSM 8903, complete genomepreprotein translocase, SecA subunit0828
NC_014614:2434017:2439334243933424420272694Clostridium sticklandii, complete genomepreprotein translocase subunit, ATPase0826
NC_015873:2294312:2294312229431222967772466Megasphaera elsdenii DSM 20460, complete genomeprotein translocase subunit secA0826
NC_016630:1610723:1616765161676516195092745Filifactor alocis ATCC 35896 chromosome, complete genomehypothetical protein0825
NC_015949:1957185:1967416196741619699622547Caldicellulosiruptor lactoaceticus 6A chromosome, complete genomeProtein translocase subunit secA0825
NC_014721:508000:5186055186055211512547Caldicellulosiruptor kristjanssonii 177R1B chromosome, completepreprotein translocase, seca subunit0825
NC_015660:391627:4151904151904177032514Geobacillus thermoglucosidasius C56-YS93 chromosome, completepreprotein translocase subunit SecA0822
NC_014650:376070:4038154038154063282514Geobacillus sp. Y4.1MC1 chromosome, complete genomepreprotein translocase subunit SecA0822
NC_013171:1336000:1337161133716113398752715Anaerococcus prevotii DSM 20548, complete genomepreprotein translocase, SecA subunit0816
NC_012914:6583000:6585429658542965879362508Paenibacillus sp. JDR-2, complete genomepreprotein translocase, SecA subunit0816
NC_014483:4772856:4793347479334747957972451Paenibacillus polymyxa E681 chromosome, complete genomePreprotein translocase secA subunit0815
NC_013406:6568273:6571239657123965737522514Paenibacillus sp. Y412MC10 chromosome, complete genomepreprotein translocase subunit SecA0807
NC_014829:3822125:3843525384352538460442520Bacillus cellulosilyticus DSM 2522 chromosome, complete genomepreprotein translocase, SecA subunit0799
NC_015977:2718437:2743055274305527456312577Roseburia hominis A2-183 chromosome, complete genomepreprotein translocase subunit SecA0796
NC_011773:4940921:4969672496967249721792508Bacillus cereus AH820 chromosome, complete genomepreprotein translocase subunit SecA0791
NC_010184:4909183:4940933494093349434402508Bacillus weihenstephanensis KBAB4, complete genomepreprotein translocase, SecA subunit0791
NC_014831:218696:2279212279212307792859Thermaerobacter marianensis DSM 12885 chromosome, complete genomeprotein translocase subunit secA0790
NC_017200:4995075:5022916502291650254232508Bacillus thuringiensis serovar finitimus YBT-020 chromosome,preprotein translocase subunit SecA0790
NC_011658:4925346:4934432493443249369392508Bacillus cereus AH187 chromosome, complete genomepreprotein translocase subunit SecA0790
NC_011969:4841358:4869242486924248717492508Bacillus cereus Q1 chromosome, complete genomepreprotein translocase subunit seca0790
NC_016771:4882886:4886755488675548892622508Bacillus cereus NC7401, complete genomePreprotein translocase subunit SecA0790
NC_020410:3326944:3355254335525433577792526Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completetranslocase binding subunit (ATPase)0789
NC_005957:4904000:4913139491313949156462508Bacillus thuringiensis serovar konkukian str. 97-27, completetranslocase0789
NC_014335:4848389:4857969485796948604762508Bacillus cereus biovar anthracis str. CI chromosome, completetranslocase0789
NC_006274:4940922:4969463496946349719702508Bacillus cereus E33L, complete genometranslocase0789
NC_012472:4908245:4935067493506749375742508Bacillus cereus 03BB102, complete genomepreprotein translocase, SecA subunit0789
NC_008600:4898000:4924801492480149273082508Bacillus thuringiensis str. Al Hakam, complete genomepreprotein translocase, SecA subunit0789
NC_016779:4864056:4889800488980048923072508Bacillus cereus F837/76 chromosome, complete genomeProtein export cytoplasm protein SecA ATPase RNA helicase0789
NC_003909:4854379:4881414488141448839212508Bacillus cereus ATCC 10987, complete genometranslocase0789
NC_017208:5143500:5152745515274551552522508Bacillus thuringiensis serovar chinensis CT-43 chromosome, completepreprotein translocase subunit SecA0789
NC_007530:4877500:4908480490848049109872508Bacillus anthracis str. 'Ames Ancestor', complete genometranslocase0787
NC_003997:4876415:4908354490835449108612508Bacillus anthracis str. Ames, complete genometranslocase0787
NC_005945:4898841:4909691490969149121982508Bacillus anthracis str. Sterne, complete genometranslocase0787
NC_012581:4882525:4910803491080349133102508Bacillus anthracis str. CDC 684 chromosome, complete genomepreprotein translocase subunit SecA0787
NC_012659:4877410:4908380490838049108872508Bacillus anthracis str. A0248, complete genomepreprotein translocase subunit SecA0787
NC_017195:3426000:3427229342722934297542526Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completePreprotein translocase subunit secA0786
NC_019896:577594:5941625941625966872526Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completePreprotein translocase SecA0786
NC_014171:4959248:4987504498750449900112508Bacillus thuringiensis BMB171 chromosome, complete genomepreprotein translocase subunit SecA0785
NC_011725:5075285:5103142510314251056492508Bacillus cereus B4264 chromosome, complete genomepreprotein translocase subunit SecA0785
NC_011772:5021404:5049590504959050520972508Bacillus cereus G9842, complete genomepreprotein translocase, SecA subunit0785
NC_004193:2553630:2554822255482225573382517Oceanobacillus iheyensis HTE831, complete genometranslocase0768
NC_019978:2220863:2234379223437922369912613Halobacteroides halobius DSM 5150, complete genomepreprotein translocase, SecA subunit0766
NC_011661:1411383:1423206142320614255692364Dictyoglomus turgidum DSM 6724, complete genomepreprotein translocase, SecA subunit0764
NC_017511:602000:6207336207336234832751Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomepreprotein translocase subunit SecA0764
NC_011297:1224749:1242937124293712453002364Dictyoglomus thermophilum H-6-12, complete genomepreprotein translocase, SecA subunit0762
NC_010003:903433:9149549149549174282475Petrotoga mobilis SJ95, complete genomepreprotein translocase, SecA subunit0762
NC_010001:312500:3154313154313180072577Clostridium phytofermentans ISDg, complete genomepreprotein translocase, SecA subunit0760
NC_007350:2019623:2025872202587220284032532Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305,preprotein translocase subunit0759
NC_017353:2129738:2163968216396821664992532Staphylococcus lugdunensis N920143, complete genomepreprotein translocase subunit SecA0759
NC_011999:530930:5309305309305334582529Macrococcus caseolyticus JCSC5402, complete genomepreprotein translocase subunit SecA0754
NC_013715:699400:7134267134267160802655Rothia mucilaginosa DY-18, complete genomepreprotein translocase subunit SecA0747
NC_012039:480625:4976864976865002772592Campylobacter lari RM2100, complete genomepreprotein translocase, SecA subunit0746
NC_014315:226693:2452922452922480032712Nitrosococcus watsoni C-113 chromosome, complete genomepreprotein translocase subunit SecA0745
NC_014924:725380:7253807253807281182739Pseudoxanthomonas suwonensis 11-1 chromosome, complete genomepreprotein translocase, SecA subunit0744
NC_017094:1703000:1726342172634217290772736Leptospirillum ferrooxidans C2-3, complete genomePreprotein translocase subunit SecA0740
NC_014643:54500:6757667576701852610Rothia dentocariosa ATCC 17931 chromosome, complete genomepreprotein translocase subunit SecA0739
NC_012785:2010668:2034105203410520365672463Kosmotoga olearia TBF 19.5.1, complete genomepreprotein translocase, SecA subunit0735
NC_011901:837085:8370858370858398622778Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completepreprotein translocase subunit SecA0735
NC_018868:3943088:3943088394308839457872700Simiduia agarivorans SA1 = DSM 21679 chromosome, complete genomepreprotein translocase subunit SecA0734
NC_008576:4130000:4144244414424441469492706Magnetococcus sp. MC-1, complete genomepreprotein translocase, SecA subunit0734
NC_014758:1992683:2012812201281220154092598Calditerrivibrio nitroreducens DSM 19672 chromosome, completeprotein translocase subunit seca0731
NC_012438:159927:1754331754331782222790Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomepreprotein translocase subunit SecA0727
NC_015722:209722:2256622256622282652604Candidatus Midichloria mitochondrii IricVA chromosome, completepreprotein translocase subunit SecA0723
NC_010084:3051355:3078524307852430813222799Burkholderia multivorans ATCC 17616 chromosome 1, completepreprotein translocase subunit SecA0723
NC_003450:788000:7962507962507987872538Corynebacterium glutamicum ATCC 13032, complete genomepreprotein translocase subunit SecA0718
NC_009342:951761:9565019565019590382538Corynebacterium glutamicum R chromosome, complete genomepreprotein translocase subunit SecA0718
NC_015380:99919:1209721209721235722601Candidatus Pelagibacter sp. IMCC9063 chromosome, complete genomeprotein export cytoplasm protein SecA ATPase RNA helicase0717
NC_002505:2537655:2560390256039025631012712Vibrio cholerae O1 biovar eltor str. N16961 chromosome I, completetranslocase0712
NC_009457:2095366:2113622211362221163332712Vibrio cholerae O395 chromosome 2, complete sequencepreprotein translocase subunit SecA0712
NC_012578:2479150:2497405249740525001162712Vibrio cholerae M66-2 chromosome I, complete sequencepreprotein translocase subunit SecA0712
NC_012582:2626786:2645042264504226477532712Vibrio cholerae O395 chromosome chromosome I, complete sequencepreprotein translocase, SecA subunit0712
NC_016445:2012294:2030544203054420332552712Vibrio cholerae O1 str. 2010EL-1786 chromosome 1, completepreprotein translocase subunit SecA0712
NC_016944:2588435:2606688260668826093992712Vibrio cholerae IEC224 chromosome I, complete sequencepreprotein translocase subunit SecA0712
NC_021066:3201500:3225898322589832286032706Raoultella ornithinolytica B6, complete genomepreprotein translocase subunit SecA0711
NC_007912:1111093:1111093111109311138462754Saccharophagus degradans 2-40, complete genomeTonB-dependent receptor0707
NC_008825:2889933:2920406292040629231622757Methylibium petroleiphilum PM1, complete genomepreprotein translocase SecA subunit0706
NC_015563:1240978:1262025126202512647722748Delftia sp. Cs1-4 chromosome, complete genomeprotein translocase subunit secA0704
NC_010159:3033989:3054756305475630574702715Yersinia pestis Angola, complete genomepreprotein translocase, SecA subunit0703
NC_011295:847903:8659568659568682742319Coprothermobacter proteolyticus DSM 5265, complete genomepreprotein translocase, SecA subunit0703
NC_015731:3274739:3298680329868033014122733Nitrosomonas sp. Is79A3 chromosome, complete genomeProtein translocase subunit secA0702
NC_011992:773905:7864207864207891732754Acidovorax ebreus TPSY, complete genomepreprotein translocase, SecA subunit0702
NC_009654:2940278:2946510294651029492122703Marinomonas sp. MWYL1, complete genomepreprotein translocase, SecA subunit0700
NC_014363:114239:1683761683761711262751Olsenella uli DSM 7084 chromosome, complete genomeprotein translocase subunit secA0693
NC_007205:499808:4998084998085023722565Candidatus Pelagibacter ubique HTCC1062, complete genomepreprotein translocase secA0693
NC_009718:1411793:1419408141940814220022595Fervidobacterium nodosum Rt17-B1, complete genomepreprotein translocase subunit SecA0693
NC_013203:1447340:1447340144734014500902751Atopobium parvulum DSM 20469, complete genomepreprotein translocase, SecA subunit0692
NC_015587:905255:9112279112279140612835Hydrogenobaculum sp. SHO chromosome, complete genomeProtein translocase subunit secA0688
NC_020411:905335:9113079113079141412835Hydrogenobaculum sp. HO, complete genomepreprotein translocase, SecA subunit0688
NC_015557:905145:9111179111179139512835Hydrogenobaculum sp. 3684 chromosome, complete genomepreprotein translocase, SecA subunit0688
NC_011126:922182:9260639260639288972835Hydrogenobaculum sp. Y04AAS1, complete genomepreprotein translocase, SecA subunit0687
NC_016632:230500:2536202536202563312712Serratia symbiotica str. 'Cinara cedri' chromosome, completepreprotein translocase subunit (ATPase)0687
NC_018419:509500:5101715101715128822712Secondary endosymbiont of Ctenarytaina eucalypti chromosome,preprotein translocase, SecA subunit0681
NC_015276:2769000:2777222277722227799212700Marinomonas mediterranea MMB-1 chromosome, complete genomeProtein translocase subunit secA0671
NC_011025:134292:1479681479681505682601Mycoplasma arthritidis 158L3-1, complete genomepreprotein translocase subunit SecA0645
NC_006055:44649:7061570615734462832Mesoplasma florum L1, complete genometranslocase2e-179629
NC_002162:138334:1548951548951574082514Ureaplasma parvum serovar 3 str. ATCC 700970, complete genometranslocase1e-153544
NC_015064:1984662:2000377200037720033702994Acidobacterium sp. MP5ACTX9 chromosome, complete genomepreprotein translocase, SecA subunit3e-149529
NC_014150:1006000:1017523101752310204652943Brachyspira murdochii DSM 12563 chromosome, complete genomepreprotein translocase, SecA subunit9e-148524
NC_012225:1015452:1027930102793010308722943Brachyspira hyodysenteriae WA1, complete genomepreprotein translocase, SecA subunit2e-147523
NC_005071:87907:8862688626914722847Prochlorococcus marinus str. MIT 9313, complete genometranslocase7e-142504
NC_015577:676453:6848016848016910946294Treponema azotonutricium ZAS-9 chromosome, complete genometranslocase2e-141503
NC_016935:4038265:4050449405044940527252277Paenibacillus mucilaginosus 3016 chromosome, complete genomeprotein SecA28e-134478
NC_015690:3477573:3492210349221034944862277Paenibacillus mucilaginosus KNP414 chromosome, complete genomeSecA21e-133477
NC_014334:1039248:1053640105364010557812142Lactobacillus casei str. Zhang chromosome, complete genomepreprotein translocase subunit SecA1e-129464
NC_010571:2041277:2057125205712520601393015Opitutus terrae PB90-1, complete genomepreprotein translocase, SecA subunit3e-122439
NC_015496:2279829:2286732228673222900943363Krokinobacter diaphorus 4H-3-7-5 chromosome, complete genomepreprotein translocase, SecA subunit9e-117421
NC_014759:2099623:2109409210940921127623354Marivirga tractuosa DSM 4126 chromosome, complete genomeprotein translocase subunit seca5e-116419
NC_004663:5741436:5751554575155457548743321Bacteroides thetaiotaomicron VPI-5482, complete genometranslocase7e-115415
NC_012590:1446500:1448007144800714502982292Corynebacterium aurimucosum ATCC 700975, complete genomepreprotein translocase SecA2 subunit3e-114413
NC_015510:4113505:4128738412873841320643327Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeprotein translocase subunit secA3e-114413
NC_016510:2856000:2867170286717028705323363Flavobacterium columnare ATCC 49512 chromosome, complete genomepreprotein translocase subunit SecA6e-114412
NC_011565:469962:4748704748704782293360Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,preprotein translocase subunit SecA4e-113409
NC_016932:1041306:1065554106555410678512298Corynebacterium pseudotuberculosis 316 chromosome, complete genomeprotein translocase subunit secA 29e-112404
NC_020156:49666:5721157211606303420Nonlabens dokdonensis DSW-6, complete genomeprotein translocase subunit SecA1e-110401
NC_013730:5989387:6014670601467060180623393Spirosoma linguale DSM 74, complete genomepreprotein translocase, SecA subunit6e-108392
NC_010118:133256:1345581345581376143057Candidatus Sulcia muelleri GWSS, complete genometranslocase4e-52206
NC_017044:702483:7024837024837091546672Rickettsia parkeri str. Portsmouth chromosome, complete genomepreprotein translocase SecA subunit-like protein2e-30135
NC_017028:1030000:1032104103210410387906687Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completepreprotein translocase SecA subunit-like protein7e-30133
NC_010830:1451887:1458556145855614649246369Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein3e-1584.3
NC_010830:632978:63933163933165295313623Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein1e-1275.5
NC_005070:1978000:199042319904231990677255Synechococcus sp. WH 8102, complete genomehypothetical protein1e-0758.9