Pre_GI: BLASTP Hits

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Query: NC_009089:3241918:3244556 Clostridium difficile 630, complete genome

Start: 3244556, End: 3244957, Length: 402

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013315:3073652:307365230736523074047396Clostridium difficile CD196 chromosome, complete genomecell wall teichoic acid glycosylation protein7e-63238
NC_007929:1290568:130665813066581307068411Lactobacillus salivarius subsp. salivarius UCC118, complete genomeCell wall teichoic acid glycosylation protein gtcA6e-2095.9
NC_014376:869749:887322887322887747426Clostridium saccharolyticum WM1 chromosome, complete genomeGtrA family protein1e-1995.5
NC_010610:1580483:162682616268261627260435Lactobacillus fermentum IFO 3956, complete genometeichoic acid glycosylation protein9e-1785.5
NC_008054:1617544:162154016215401621968429Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842, completeTeichoic acid glycosylation protein4e-1476.6
NC_008529:1634403:163838416383841638812429Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365, completeConserved membrane protein, GtcA family5e-1476.3
NC_009633:337706:345154345154345573420Alkaliphilus metalliredigens QYMF chromosome, complete genomeGtrA family protein2e-1167.4
NC_010531:292044:301384301384301809426Polynucleobacter necessarius STIR1, complete genomeGtrA family protein3e-0650.4
NC_016513:1958500:196866819686681969036369Aggregatibacter actinomycetemcomitans ANH9381 chromosome, completedTDP-glucose-4-keto-6-deoxy-D-glucose reductase7e-0649.3