Pre_GI: BLASTP Hits

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Query: NC_009089:2150062:2155769 Clostridium difficile 630, complete genome

Start: 2155769, End: 2164804, Length: 9036

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_013316:2033906:2098383209838321071128730Clostridium difficile R20291, complete genomeputative helicase03447
NC_012470:1390285:1417879141787914266298751Streptococcus equi subsp. zooepidemicus, complete genomehelicase03413
NC_009089:478328:4961224961225048458724Clostridium difficile 630, complete genomeputative helicase03370
NC_016630:1247251:1274510127451012833448835Filifactor alocis ATCC 35896 chromosome, complete genomesuperfamily II DNA and RNA helicase03346
NC_012471:1197534:12378191237819124974611928Streptococcus equi subsp. equi 4047, complete genomeconjugative transposon DNA recombination protein02179
NC_013164:67500:8255982559888556297Anaerococcus prevotii DSM 20548 plasmid pAPRE01, complete sequencehelicase domain protein02122
NC_013192:1033177:1035019103501910414146396Leptotrichia buccalis DSM 1135, complete genomehelicase domain protein02024
NC_018867:121512:1272861272861351547869Dehalobacter sp. CF chromosome, complete genomehypothetical protein01705
NC_012781:3315614:3326686332668633343687683Eubacterium rectale ATCC 33656, complete genomepossible adenine-specific DNA methylase01702
NC_018867:10238:3975439754464676714Dehalobacter sp. CF chromosome, complete genomeDNA methylase01686
NC_018866:63498:8623786237938087572Dehalobacter sp. DCA chromosome, complete genomeSuperfamily II DNA and RNA helicase01679
NC_014828:2038692:2038692203869220460807389Ethanoligenens harbinense YUAN-3 chromosome, complete genomeDEAD-like helicase01644
NC_016048:2873669:2873669287366928818468178Oscillibacter valericigenes Sjm18-20, complete genomeputative helicase01609
NC_004668:2198027:2223189222318922327109522Enterococcus faecalis V583, complete genomehypothetical protein01583
NC_008023:1070986:1103910110391011111607251Streptococcus pyogenes MGAS2096, complete genomeSuperfamily II DNA and RNA helicase01430
NC_015977:3424178:3490227349022734964846258Roseburia hominis A2-183 chromosome, complete genomehelicase01360
NC_014624:1768226:1789525178952517970187494Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein01332
NC_012470:1390285:1402182140218214043142133Streptococcus equi subsp. zooepidemicus, complete genome01299
NC_014393:2771774:2771774277177427805028729Clostridium cellulovorans 743B chromosome, complete genome01231
NC_015422:3413386:3448201344820134532435043Alicycliphilus denitrificans K601 chromosome, complete genomeDEAD-like helicase01033
NC_018866:63498:6349863498695276030Dehalobacter sp. DCA chromosome, complete genomeSuperfamily II DNA and RNA helicase0929
NC_008757:206036:2060362060362109854950Polaromonas naphthalenivorans CJ2 plasmid pPNAP01, completehelicase, C-terminal0870
NC_012654:237175:2477992477992517193921Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequencesuperfamily II DNA and RNA helicase0842
NC_014801:1:2447244782545808Campylobacter jejuni subsp. jejuni ICDCCJ07001 plasmid pTet,cpp140801
NC_013211:163390:1633901633901685165127Acetobacter pasteurianus IFO 3283-01 plasmid pAPA01-020, completeDNA methylase/helicase SNF20768
NC_017105:163390:1633901633901685165127Acetobacter pasteurianus IFO 3283-01-42C plasmid pAPA42C_020,DNA methylase/helicase SNF20768
NC_017113:163390:1633901633901685165127Acetobacter pasteurianus IFO 3283-12 plasmid pAPA12-020, completeDNA methylase/helicase SNF20768
NC_017118:163390:1633901633901685165127Acetobacter pasteurianus IFO 3283-03 plasmid pAPA03-020, completeDNA methylase/helicase SNF20768
NC_017122:163390:1633901633901685165127Acetobacter pasteurianus IFO 3283-07 plasmid pAPA07-020, completeDNA methylase/helicase SNF20768
NC_017126:163390:1633901633901685165127Acetobacter pasteurianus IFO 3283-22 plasmid pAPA22-020, completeDNA methylase/helicase SNF20768
NC_017131:163390:1633901633901685165127Acetobacter pasteurianus IFO 3283-26 plasmid pAPA26-020, completeDNA methylase/helicase SNF20768
NC_017149:163390:1633901633901685165127Acetobacter pasteurianus IFO 3283-32 plasmid pAPA32-020, completeDNA methylase/helicase SNF20768
NC_011881:46654:4665446654514744821Arthrobacter chlorophenolicus A6 plasmid pACHL02, completehelicase domain protein0759
NC_008539:1:101047374728Arthrobacter sp. FB24 plasmid 3, complete sequencehelicase domain protein0734
NC_016749:1371997:1375578137557813823996822Streptococcus macedonicus ACA-DC 198, complete genomeSNF2 family protein0717
NC_004116:1276791:1283738128373812905626825Streptococcus agalactiae 2603V/R, complete genomeSNF2 family protein0703
NC_015052:1313311:1342134134213413485806447Bifidobacterium longum subsp. infantis 157F, complete genomehypothetical protein0696
NC_019744:20500:2169421694268115118Cylindrospermum stagnale PCC 7417 plasmid pCYLST.02, completeDNA methylase0695
NC_009714:113975:1366831366831430366354Campylobacter hominis ATCC BAA-381, complete genomeCpp140678
NC_012470:1390285:1404359140435914057081350Streptococcus equi subsp. zooepidemicus, complete genome0639
NC_015164:438000:4633524633524683254974Bacteroides salanitronis DSM 18170 chromosome, complete genomehelicase domain-containing protein4e-178627
NC_015600:1161640:1169203116920311751995997Streptococcus pasteurianus ATCC 43144, complete genomeSNF2/helicase family protein2e-176622
NC_014041:3715000:3721081372108137266095529Zunongwangia profunda SM-A87 chromosome, complete genomeputative DNA methylase8e-132473
NC_014256:448710:4717384717384792947557Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-130469
NC_016776:2411154:2416657241665724223925736Bacteroides fragilis 638R, complete genomeputative DNA methylase1e-126456
NC_004663:2859158:2903302290330229090285727Bacteroides thetaiotaomicron VPI-5482, complete genomeputative DNA methylase6e-125451
NC_016610:1310275:1323084132308413289485865Tannerella forsythia ATCC 43037 chromosome, complete genomehelicase C-terminal domain-containing protein7e-121437
NC_015164:2935363:2947762294776229535935832Bacteroides salanitronis DSM 18170 chromosome, complete genomehelicase domain-containing protein9e-118427
NC_006347:143876:1500911500911559075817Bacteroides fragilis YCH46, complete genomeputative DNA methylase1e-117426
NC_016776:215500:2197882197882252745487Bacteroides fragilis 638R, complete genomeputative DNA methylase9e-117423
NC_015571:1030527:1030527103052710360195493Porphyromonas gingivalis TDC60, complete genomeDNA methylase1e-116423
NC_015311:2531616:2533794253379425400756282Prevotella denticola F0289 chromosome, complete genomehelicase C-terminal domain-containing protein3e-116422
NC_015177:1859879:1863608186360818690465439Pedobacter saltans DSM 12145 chromosome, complete genomeN-6 DNA methylase9e-112407
NC_017063:834674:8539908539908625368547Helicobacter pylori ELS37 chromosome, complete genomeadenine specific DNA methyltransferase2e-107392
NC_011333:1040192:1067764106776410761908427Helicobacter pylori G27 chromosome, complete genomeadenine specific DNA methyltransferase4e-107391
NC_017372:748097:7732547732547818548601Helicobacter pylori India7 chromosome, complete genomeadenine specific DNA methyltransferase3e-106389
NC_011498:448000:4620964620964705228427Helicobacter pylori P12, complete genomeDNA methylase4e-106388
NC_014560:1366747:1382017138201713905218505Helicobacter pylori SJM180 chromosome, complete genomeadenine specific DNA methyltransferase2e-105385
NC_017361:1528239:1550176155017615585848409Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein6e-105384
NC_017361:930280:9432999432999517078409Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein1e-104383
NC_017375:1498000:1504994150499415134118418Helicobacter pylori 83 chromosome, complete genomeDNA methylase1e-103380
NC_017362:1512959:1542212154221215508128601Helicobacter pylori Lithuania75 chromosome, complete genomeadenine specific DNA methyltransferase2e-103379
NC_000921:1007519:1025324102532410320196696Helicobacter pylori J99, complete genomehypothetical protein2e-103379
NC_017376:57500:7006270062784888427Helicobacter pylori SNT49 chromosome, complete genomeDNA methylase3e-103378
NC_010698:870312:8833758833758917868412Helicobacter pylori Shi470, complete genomehypothetical protein5e-103378
NC_017378:1518529:1526278152627815321095832Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein5e-103378
NC_004663:6223442:6231192623119262351543963Bacteroides thetaiotaomicron VPI-5482, complete genomeputative DNA methylase7e-103377
NC_017367:278916:3063993063993148558457Helicobacter pylori F57, complete genomehypothetical protein6e-103377
NC_009614:2723262:2728033272803327319953963Bacteroides vulgatus ATCC 8482 chromosome, complete genomeDNA methylase7e-102374
NC_014828:1019533:1042524104252410437381215Ethanoligenens harbinense YUAN-3 chromosome, complete genomehypothetical protein5e-85318
NC_017366:1055319:1062619106261910661703552Helicobacter pylori F32, complete genomehypothetical protein1e-83313
NC_002950:1571383:1576239157623915785302292Porphyromonas gingivalis W83, complete genomehypothetical protein4e-77291
NC_010729:1179008:1196323119632311997903468Porphyromonas gingivalis ATCC 33277, complete genomeputative DNA methylase7e-69264
NC_008023:1070986:109209210920921093030939Streptococcus pyogenes MGAS2096, complete genomeSuperfamily II DNA and RNA helicase2e-67259
NC_015571:2044000:2044072204407220474853414Porphyromonas gingivalis TDC60, complete genomeDNA methylase2e-67259
NC_014371:849198:8669838669838715964614Prevotella melaninogenica ATCC 25845 chromosome chromosome II,hypothetical protein9e-58227
NC_015311:1860666:1875988187598818804634476Prevotella denticola F0289 chromosome, complete genomehypothetical protein4e-50202
NC_002950:879930:9078949078949094741581Porphyromonas gingivalis W83, complete genomehypothetical protein3e-42176
NC_015311:1860666:1898091189809118995661476Prevotella denticola F0289 chromosome, complete genomehelicase C-terminal domain-containing protein3e-40169
NC_012471:719000:748826748826749062237Streptococcus equi subsp. equi 4047, complete genome2e-36157
NC_015386:150000:1544931544931609006408Treponema succinifaciens DSM 2489 plasmid pTRESU01, completeSNF2-related protein4e-33145
NC_015571:2044000:2047485204748520497642280Porphyromonas gingivalis TDC60, complete genomeN-6 DNA Methylase2e-31140
NC_015385:1838268:1857415185741518661208706Treponema succinifaciens DSM 2489 chromosome, complete genomeSNF2-related protein8e-30134
NC_012654:237175:244155244155245033879Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequencesuperfamily II DNA and RNA helicase8e-28128
NC_008255:1701195:1701195170119517053344140Cytophaga hutchinsonii ATCC 33406, complete genomehelicase, SNF2 family3e-20102
NC_017177:192933:194771194771195619849Clostridium difficile BI1, complete genomeN-6 DNA methylase3e-1586.3
NC_009089:478328:4894514894514915832133Clostridium difficile 630, complete genomehypothetical protein5e-1585.5
NC_016630:1247251:1286269128626912885632295Filifactor alocis ATCC 35896 chromosome, complete genomeNlpC/P60 family protein1e-1484.3
NC_013316:2033906:2091712209171220938442133Clostridium difficile R20291, complete genomehypothetical protein5e-1482.4
NC_012470:1390285:1431971143197114340942124Streptococcus equi subsp. zooepidemicus, complete genomemembrane protein1e-1381.3
NC_015425:1295261:130377013037701304192423Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein2e-1380.5
NC_019968:1084288:1111083111108311121651083Prevotella dentalis DSM 3688 chromosome 2, complete sequence4e-1379.7
NC_009089:2150062:21362292136229218593049702Clostridium difficile 630, complete genome9e-1378.2
NC_012471:719000:7310687310687331912124Streptococcus equi subsp. equi 4047, complete genomemembrane protein8e-1378.2
NC_015600:1161640:116604211660421166851810Streptococcus pasteurianus ATCC 43144, complete genome2e-1173.9
NC_012470:1946968:197379519737951973995201Streptococcus equi subsp. zooepidemicus, complete genome3e-0966.6
NC_008255:1701195:170564117056411706405765Cytophaga hutchinsonii ATCC 33406, complete genomepossible adenine-specific DNA methylase9e-0965.1
NC_009523:585367:5853675853675883272961Roseiflexus sp. RS-1 chromosome, complete genomehelicase domain-containing protein5e-0862.4
NC_015510:6842692:6862351686235168649722622Haliscomenobacter hydrossis DSM 1100 chromosome, complete genomeSNF2-like protein8e-0758.5
NC_014624:1768226:178896817889681789519552Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein8e-0758.5
NC_015958:2206032:2207797220779722105082712Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomehelicase domain-containing protein7e-0758.5
NC_011880:56543:6300363003656872685Cyanothece sp. PCC 7425 plasmid pP742501, complete sequencehelicase domain protein3e-0656.6
NC_020134:1941523:1970369197036919730682700Clostridium stercorarium subsp. stercorarium DSM 8532, completehelicase domain protein4e-0656.2
NC_010424:531727:5411445411445445873444Candidatus Desulforudis audaxviator MP104C, complete genomehelicase domain protein5e-0655.8
NC_011774:115228:2125212535311407Bacillus cereus G9842 plasmid pG9842_140, complete sequenceRecQ helicase, putative1e-0555.1