Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1351740 Clostridium difficile 630, complete genome

Start: 1351740, End: 1352153, Length: 414

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:121967712196771220090414Clostridium difficile BI1, complete genomemethylglyoxal synthase9e-77284
NC_013315:1187986:120990012099001210313414Clostridium difficile CD196 chromosome, complete genomemethylglyoxal synthase9e-77284
NC_009633:2350892:236544323654432365847405Alkaliphilus metalliredigens QYMF chromosome, complete genomemethylglyoxal synthase9e-46181
NC_007530:1459412:146648514664851466880396Bacillus anthracis str. 'Ames Ancestor', complete genomemethylglyoxal synthase2e-42170
NC_005945:1459357:146643914664391466834396Bacillus anthracis str. Sterne, complete genomemethylglyoxal synthase2e-42170
NC_014328:794000:809537809537809908372Clostridium ljungdahlii ATCC 49587 chromosome, complete genomemethylglyoxal synthase3e-36150
NC_005835:1345790:136439913643991364785387Thermus thermophilus HB27, complete genomemethylglyoxal synthase7e-32135
NC_017078:179848:179848179848180264417Selenomonas ruminantium subsp. lactilytica TAM6421 plasmid pSRC1,putative methylglyoxal synthase9e-31132
NC_015136:1141925:116979411697941170183390Burkholderia sp. CCGE1001 chromosome 1, complete sequencemethylglyoxal synthase1e-27121
NC_014221:266638:274456274456274881426Truepera radiovictrix DSM 17093 chromosome, complete genomemethylglyoxal synthase3e-27120
NC_007516:2277910:232647723264772327370894Synechococcus sp. CC9605, complete genomecyclic nucleotide-binding domain (cNMP-BD) protein3e-27120
NC_006511:1808815:182934118293411829799459Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCCmethylglyoxal synthase5e-27119
NC_011149:1035990:103808010380801038538459Salmonella enterica subsp. enterica serovar Agona str. SL483,methylglyoxal synthase5e-27119
NC_010102:2020762:203905520390552039513459Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein5e-27119
NC_010067:1829041:185540118554011855859459Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein5e-27119
NC_004631:1881214:190279519027951903253459Salmonella enterica subsp. enterica serovar Typhi Ty2, completemethylglyoxal synthase5e-27119
NC_011147:1802535:182452418245241824982459Salmonella enterica subsp. enterica serovar Paratyphi A strmethylglyoxal synthase5e-27119
NC_012125:2687980:270628427062842706742459Salmonella enterica subsp. enterica serovar Paratyphi C strainmethylglyoxal synthase5e-27119
NC_016832:1880174:189964518996451900103459Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,Methylglyoxal synthase5e-27119
NC_016831:1950650:196895319689531969396444Salmonella enterica subsp. enterica serovar Gallinarum/pullorummethylglyoxal synthase4e-27119
NC_010519:275976:278166278166278624459Haemophilus somnus 2336 chromosome, complete genomemethylglyoxal synthase4e-27119
NC_014618:2989000:300650930065093006967459Enterobacter cloacae SCF1 chromosome, complete genomemethylglyoxal synthase2e-26117
NC_013421:3093995:311224031122403112698459Pectobacterium wasabiae WPP163, complete genomemethylglyoxal synthase1e-25114
NC_012880:3125261:314536831453683145826459Dickeya dadantii Ech703, complete genomemethylglyoxal synthase2e-25114
NC_014960:3009500:301670130167013017156456Anaerolinea thermophila UNI-1, complete genomemethylglyoxal synthase3e-25114
NC_003143:1630000:163493716349371635401465Yersinia pestis CO92, complete genomemethylglyoxal synthase4e-25113
NC_008149:2802392:284828928482892848753465Yersinia pestis Nepal516, complete genomemethylglyoxal synthase4e-25113
NC_008150:844727:846842846842847306465Yersinia pestis Antiqua, complete genomemethylglyoxal synthase4e-25113
NC_014029:1702338:170445317044531704917465Yersinia pestis Z176003 chromosome, complete genomemethylglyoxal synthase4e-25113
NC_017154:1644404:164651916465191646983465Yersinia pestis D106004 chromosome, complete genomemethylglyoxal synthase4e-25113
NC_007760:1415663:143657914365791437055477Anaeromyxobacter dehalogenans 2CP-C, complete genomemethylglyoxal synthase1e-24111
NC_008578:1827605:182966418296641830167504Acidothermus cellulolyticus 11B, complete genomemethylglyoxal synthase3e-21100
NC_006569:370846:370463370463370852390Silicibacter pomeroyi DSS-3 megaplasmid, complete sequencemethylglyoxal synthase3e-21100
NC_006347:4378684:439488743948874395405519Bacteroides fragilis YCH46, complete genomemethylglyoxal synthase4e-2096.7
NC_004663:1365429:138525613852561385792537Bacteroides thetaiotaomicron VPI-5482, complete genomemethylglyoxal synthase9e-2095.5
NC_011060:1288862:131154813115481312534987Pelodictyon phaeoclathratiforme BU-1, complete genomeMethylglyoxal synthase-like protein4e-1580.1
NC_010002:5691968:570910357091035709975873Delftia acidovorans SPH-1, complete genomehypothetical protein1e-1375.1