Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1339983 Clostridium difficile 630, complete genome

Start: 1339983, End: 1340558, Length: 576

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:120792012079201208495576Clostridium difficile BI1, complete genomeelectron transport complex protein4e-101366
NC_013315:1187986:119814311981431198718576Clostridium difficile CD196 chromosome, complete genomeelectron transport complex protein4e-101366
NC_013316:1186156:119575911957591196334576Clostridium difficile R20291, complete genomeelectron transport complex protein4e-101366
NC_009633:2350892:235437623543762354966591Alkaliphilus metalliredigens QYMF chromosome, complete genomeRnfABCDGE type electron transport complex subunit A2e-65248
NC_014632:11925:244412444125025585Ilyobacter polytropus DSM 2926 chromosome, complete genomeRnfABCDGE type electron transport complex subunit A9e-64242
NC_003454:63500:103252103252103836585Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeNa(+)-translocating NADH-quinone reductase subunit D4e-61233
NC_010718:517473:526291526291526866576Natranaerobius thermophilus JW/NM-WN-LF, complete genomeelectron transport complex, RnfABCDGE type, A subunit9e-60229
NC_009348:2631759:264796326479632648544582Aeromonas salmonicida subsp. salmonicida A449, complete genomeNa(+)-translocating NADH-quinone reductase subunit E5e-59226
NC_015566:2328771:235114523511452351726582Serratia sp. AS12 chromosome, complete genomeRnfABCDGE type electron transport complex subunit A9e-59226
NC_015567:2328782:235102723510272351608582Serratia sp. AS9 chromosome, complete genomeRnfABCDGE type electron transport complex subunit A9e-59226
NC_014121:2330451:235691523569152357496582Enterobacter cloacae subsp. cloacae ATCC 13047 chromosome, completeelectron transport complex protein RnfA2e-58224
NC_010519:1764261:177651217765121777093582Haemophilus somnus 2336 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E8e-58223
NC_008309:1155218:117336311733631173944582Haemophilus somnus 129PT, complete genomeelectron transport complex protein6e-58223
NC_014150:648868:665121665121665702582Brachyspira murdochii DSM 12563 chromosome, complete genomeelectron transport complex, RnfABCDGE type, A subunit1e-57222
NC_018607:2032566:204917820491782049756579Brachyspira pilosicoli B2904 chromosome, complete genomeNADH:ubiquinone oxidoreductase, RnfA subunit-like protein2e-57221
NC_018604:838932:852621852621853199579Brachyspira pilosicoli WesB complete genomeNADH:ubiquinone oxidoreductase, RnfA subunit-like protein2e-57221
NC_015424:2836920:284930628493062849887582Aeromonas veronii B565 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E4e-57220
NC_017095:166896:197758197758198330573Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeRnfABCDGE type electron transport complex subunit A2e-56218
NC_016816:2508204:252947225294722530053582Pantoea ananatis LMG 5342, complete genomeRnfABCDGE type electron transport complex subunit A3e-56217
NC_009697:419443:425697425697426275579Clostridium botulinum A str. ATCC 19397 chromosome, completeRnfABCDGE type electron transport complex subunit A3e-56217
NC_013194:4964000:498312949831294983710582Candidatus Accumulibacter phosphatis clade IIA str. UW-1, completeelectron transport complex, RnfABCDGE type, A subunit6e-56216
NC_011661:1100576:111717511171751117762588Dictyoglomus turgidum DSM 6724, complete genomeelectron transport complex, RnfABCDGE type, A subunit1e-53209
NC_013959:826868:844523844523845098576Sideroxydans lithotrophicus ES-1 chromosome, complete genomeelectron transport complex, RnfABCDGE type, A subunit5e-51200
NC_020409:135699:156603156603157178576Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeputative inner membrane subunit of an electron transport system3e-50197
NC_015709:1459838:150831215083121508893582Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completeRnfABCDGE type electron transport complex subunit A4e-49194
NC_004545:96422:119467119467120051585Buchnera aphidicola str. Bp (Baizongia pistaciae), complete genomeelectron transport complex protein RnfA2e-48192
NC_017096:1147441:116671411667141167304591Caldisericum exile AZM16c01, complete genomeelectron transport complex protein RnfA1e-42172
NC_014484:371500:390182390182390775594Spirochaeta thermophila DSM 6192 chromosome, complete genomehypothetical protein8e-42169
NC_010376:1175916:119105911910591191643585Finegoldia magna ATCC 29328, complete genomesodium-translocating NADH-quinone reductase subunit E4e-41167
NC_010506:4404377:440837544083754408983609Shewanella woodyi ATCC 51908, complete genomeNADH:ubiquinone oxidoreductase, subunit E6e-41166
NC_020291:744329:750268750268750843576Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeelectron transport complex protein RnfA3e-40164
NC_010159:3502350:352080635208063521402597Yersinia pestis Angola, complete genomeNADH:ubiquinone oxidoreductase, Na(+)-translocating, E subunit2e-39162
NC_008149:1002453:100308910030891003685597Yersinia pestis Nepal516, complete genomeNa+-translocating NADH-quinone reductase subunit E2e-39162
NC_003143:3583468:360189636018963602492597Yersinia pestis CO92, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39162
NC_006155:1074298:107572710757271076323597Yersinia pseudotuberculosis IP 32953, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39162
NC_008150:3015000:303357430335743034170597Yersinia pestis Antiqua, complete genomeNa+-translocating NADH-quinone reductase subunit E2e-39162
NC_010634:1056441:105787010578701058466597Yersinia pseudotuberculosis PB1/+, complete genomeNADH:ubiquinone oxidoreductase, subunit E2e-39162
NC_010465:3597000:361462136146213615217597Yersinia pseudotuberculosis YPIII, complete genomeNADH:ubiquinone oxidoreductase, subunit E2e-39162
NC_009381:3228500:324616032461603246756597Yersinia pestis Pestoides F chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39162
NC_017265:3375463:339423633942363394832597Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,Na+-translocating NADH-quinone reductase subunit E2e-39162
NC_017168:2158839:215947521594752160071597Yersinia pestis A1122 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39162
NC_017160:3560153:357858135785813579177597Yersinia pestis D182038 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39162
NC_017154:3576256:359468435946843595280597Yersinia pestis D106004 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39162
NC_014029:3633955:365238336523833652979597Yersinia pestis Z176003 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39162
NC_009708:3542336:356076435607643561360597Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39162
NC_005810:754340:755820755820756422603Yersinia pestis biovar Microtus str. 91001, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39161
NC_004088:1075454:107608410760841076686603Yersinia pestis KIM, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-39161
NC_015571:1265121:128586912858691286483615Porphyromonas gingivalis TDC60, complete genomeNa(+)-translocating NADH-quinone reductase, subunit E4e-39160
NC_013939:1927424:193655719365571937171615Deferribacter desulfuricans SSM1, complete genomeNa(+)-translocating NADH-quinone reductase subunit E2e-37154
NC_007955:1464000:147090014709001471490591Methanococcoides burtonii DSM 6242, complete genomeelectron transport complex, RnfABCDGE type, A subunit4e-37154
NC_009348:1064664:107025410702541070853600Aeromonas salmonicida subsp. salmonicida A449, complete genomeNa(+)-translocating NADH-quinone reductase subunit E1e-36152
NC_006138:857692:871022871022871960939Desulfotalea psychrophila LSv54, complete genomesimilar to Na-translocating NADH-quinone reductase, Nqr5 subunit2e-36151
NC_015276:2852010:285727728572772857885609Marinomonas mediterranea MMB-1 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit E3e-34144
NC_007955:1464000:147149214714921472103612Methanococcoides burtonii DSM 6242, complete genomeelectron transport complex, RnfABCDGE type, E subunit7e-1890.1
NC_009697:419443:425044425044425646603Clostridium botulinum A str. ATCC 19397 chromosome, completeelectron transport complex protein RsxE6e-1787
NC_009633:2350892:235374323537432354372630Alkaliphilus metalliredigens QYMF chromosome, complete genomeRnfABCDGE type electron transport complex subunit E2e-1685.9
NC_017095:166896:197081197081197761681Fervidobacterium pennivorans DSM 9078 chromosome, complete genomeRnfABCDGE type electron transport complex subunit E2e-1685.1
NC_003454:63500:103833103833104450618Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeNADH-ubiquinone oxidoreductase3e-1684.7
NC_014632:11925:238112381124437627Ilyobacter polytropus DSM 2926 chromosome, complete genomeRnfABCDGE type electron transport complex subunit E4e-1684.7
NC_010718:517473:525561525561526181621Natranaerobius thermophilus JW/NM-WN-LF, complete genomeelectron transport complex, RnfABCDGE type, E subunit1e-1582.8
NC_010519:1764261:178153617815361782252717Haemophilus somnus 2336 chromosome, complete genomeelectron transporter subunit RsxE2e-1581.6
NC_013959:826868:849437849437850117681Sideroxydans lithotrophicus ES-1 chromosome, complete genomeelectron transport complex, RnfABCDGE type, E subunit4e-1581.3
NC_017179:1197763:120731212073121207905594Clostridium difficile BI1, complete genomeelectron transport complex protein9e-1580.1
NC_013315:1187986:119753511975351198128594Clostridium difficile CD196 chromosome, complete genomeelectron transport complex protein9e-1580.1
NC_013316:1186156:119515111951511195744594Clostridium difficile R20291, complete genomeelectron transport complex protein9e-1580.1
NC_009089:1329826:133937513393751339968594Clostridium difficile 630, complete genomeelectron transport complex protein9e-1580.1
NC_018604:838932:851968851968852615648Brachyspira pilosicoli WesB complete genomeSoxR-reducing system protein RsxE1e-1479.3
NC_018607:2032566:204976220497622050409648Brachyspira pilosicoli B2904 chromosome, complete genomeSoxR-reducing system protein RsxE1e-1479.3
NC_014150:648868:665695665695666354660Brachyspira murdochii DSM 12563 chromosome, complete genomeelectron transport complex, RnfABCDGE type, E subunit1e-1479.3
NC_015709:1459838:151284315128431513514672Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completeRnfABCDGE type electron transport complex subunit E3e-1478.6
NC_015424:2836920:285506028550602855821762Aeromonas veronii B565 chromosome, complete genomeNADH:ubiquinone oxidoreductase, Na(+)-translocating subunit D3e-1478.2
NC_020291:744329:749645749645750268624Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeelectron transport complex protein RnfE4e-1477.8
NC_020409:135699:157188157188157865678Desulfovibrio piezophilus str. nov C1TLV30 chromosome, completeputative inner membrane NADH-quinone reductase6e-1477
NC_008577:2604281:260601526060152606713699Shewanella sp. ANA-3 chromosome 1, complete sequenceelectron transport complex, RnfABCDGE type, E subunit1e-1376.3
NC_016614:686887:690060690060690740681Vibrio sp. EJY3 chromosome 2, complete sequenceelectron transport complex RsxE subunit1e-1272.8
NC_011661:1100576:111656711165671117166600Dictyoglomus turgidum DSM 6724, complete genomeelectron transport complex, RnfABCDGE type, E subunit2e-1168.6
NC_005810:754340:755190755190755819630Yersinia pestis biovar Microtus str. 91001, complete genomeNa(+)-translocating NADH-quinone reductase subunit D6e-1167.4
NC_004088:1075454:107545410754541076083630Yersinia pestis KIM, complete genomeNADH-ubiquinone oxidoreductase6e-1167.4
NC_003143:3583468:360249936024993603128630Yersinia pestis CO92, complete genomeNADH-ubiquinone oxidoreductase6e-1167.4
NC_010634:1056441:105723410572341057863630Yersinia pseudotuberculosis PB1/+, complete genomeNADH:ubiquinone oxidoreductase, subunit D6e-1167.4
NC_010159:3502350:352140935214093522038630Yersinia pestis Angola, complete genomeNADH:ubiquinone oxidoreductase, Na(+)-translocating, D subunit6e-1167.4
NC_008149:1002453:100245310024531003082630Yersinia pestis Nepal516, complete genomeNa+-translocating NADH-quinone reductase subunit D6e-1167.4
NC_006155:1074298:107509110750911075720630Yersinia pseudotuberculosis IP 32953, complete genomeNADH-ubiquinone oxidoreductase6e-1167.4
NC_008150:3015000:303417730341773034806630Yersinia pestis Antiqua, complete genomeNa+-translocating NADH-quinone reductase subunit D6e-1167.4
NC_010465:3597000:361522436152243615853630Yersinia pseudotuberculosis YPIII, complete genomeNADH:ubiquinone oxidoreductase, subunit D6e-1167.4
NC_009381:3228500:324676332467633247392630Yersinia pestis Pestoides F chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit D6e-1167.4
NC_009708:3542336:356136735613673561996630Yersinia pseudotuberculosis IP 31758 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit D6e-1167.4
NC_014029:3633955:365298636529863653615630Yersinia pestis Z176003 chromosome, complete genomeNADH-ubiquinone oxidoreductase6e-1167.4
NC_017154:3576256:359528735952873595916630Yersinia pestis D106004 chromosome, complete genomeNADH-ubiquinone oxidoreductase6e-1167.4
NC_017160:3560153:357918435791843579813630Yersinia pestis D182038 chromosome, complete genomeNADH-ubiquinone oxidoreductase6e-1167.4
NC_017168:2158839:215883921588392159468630Yersinia pestis A1122 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit D6e-1167.4
NC_017265:3375463:339483933948393395468630Yersinia pestis biovar Medievalis str. Harbin 35 chromosome,Na+-translocating NADH-quinone reductase subunit D6e-1167.4
NC_013194:4964000:497863249786324979306675Candidatus Accumulibacter phosphatis clade IIA str. UW-1, completeelectron transport complex, RnfABCDGE type, E subunit5e-1167.4
NC_004459:1794540:181948718194871820119633Vibrio vulnificus CMCP6 chromosome I, complete sequenceNADH-ubiquinone oxidoreductase5e-1064.3
NC_014484:371500:389583389583390185603Spirochaeta thermophila DSM 6192 chromosome, complete genomeNa(+)-translocating NADH-quinone reductase subunit D6e-1063.9
NC_010376:1175916:119164311916431192257615Finegoldia magna ATCC 29328, complete genomesodium-translocating NADH-quinone reductase subunit D4e-0961.2
NC_015566:2328771:234439623443962345094699Serratia sp. AS12 chromosome, complete genomeElectron transport complex protein rnfE5e-0960.8
NC_015567:2328782:234440723444072345105699Serratia sp. AS9 chromosome, complete genomeElectron transport complex protein rnfE5e-0960.8
NC_015571:1265121:128520012852001285829630Porphyromonas gingivalis TDC60, complete genomeNa(+)-translocating NADH-quinone reductase, subunit D2e-0858.9
NC_012881:334250:352808352808353425618Desulfovibrio salexigens DSM 2638, complete genomeNADH:ubiquinone oxidoreductase, subunit D4e-0857.8
NC_010506:4404377:440898944089894409621633Shewanella woodyi ATCC 51908, complete genomeNADH:ubiquinone oxidoreductase, subunit D5e-0857.4
NC_015276:2852010:285788528578852858547663Marinomonas mediterranea MMB-1 chromosome, complete genomeNADH:ubiquinone oxidoreductase, subunit D3e-0652