Pre_GI: BLASTP Hits

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Query: NC_009089:1329826:1338793 Clostridium difficile 630, complete genome

Start: 1338793, End: 1339362, Length: 570

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017179:1197763:120673012067301207299570Clostridium difficile BI1, complete genomeelectron transport complex protein5e-86316
NC_013315:1187986:119695311969531197522570Clostridium difficile CD196 chromosome, complete genomeelectron transport complex protein5e-86316
NC_013316:1186156:119456911945691195138570Clostridium difficile R20291, complete genomeelectron transport complex protein5e-86316
NC_009697:419443:424362424362425033672Clostridium botulinum A str. ATCC 19397 chromosome, completeRnfABCDGE type electron transport complex subunit G3e-30131
NC_009633:2350892:235318623531862353719534Alkaliphilus metalliredigens QYMF chromosome, complete genomeRnfABCDGE type electron transport complex subunit G6e-23107
NC_003454:63500:104450104450104983534Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeNitrogen fixation protein RNFG6e-1683.6
NC_020291:744329:749077749077749643567Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeelectron transport complex protein, subunit G1e-1479.3
NC_004557:691944:6927246927246937431020Clostridium tetani E88, complete genomeelectron transport complex protein (RnfG/NqrC)3e-1375.1
NC_014632:11925:232812328123811531Ilyobacter polytropus DSM 2926 chromosome, complete genomeRnfABCDGE type electron transport complex subunit G3e-1271.6
NC_011661:1100576:111601811160181116554537Dictyoglomus turgidum DSM 6724, complete genomeelectron transport complex, RnfABCDGE type, G subunit1e-1169.7
NC_010718:517473:524989524989525522534Natranaerobius thermophilus JW/NM-WN-LF, complete genomeelectron transport complex, RnfABCDGE type, G subunit2e-1065.5
NC_017096:1147441:116790011679001168499600Caldisericum exile AZM16c01, complete genomeputative electron transport complex protein RnfG3e-0961.6
NC_007955:1464000:147211814721181472690573Methanococcoides burtonii DSM 6242, complete genomeelectron transport complex, RnfABCDGE type, G subunit5e-0960.8
NC_016614:686887:689459689459690067609Vibrio sp. EJY3 chromosome 2, complete sequenceelectron transport complex, RnfABCDGE type, G subunit3e-0858.2
NC_006138:857692:869432869432870328897Desulfotalea psychrophila LSv54, complete genomesimilar to Na-translocating NADH-quinone reductase (RnfG/NqrC)2e-0755.8
NC_013194:4964000:497930349793034979932630Candidatus Accumulibacter phosphatis clade IIA str. UW-1, completeelectron transport complex, RnfABCDGE type, G subunit7e-0753.5
NC_015709:1459838:151214315121431512853711Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completeRnfABCDGE type electron transport complex subunit G3e-0651.6
NC_015424:2836920:285441228544122855044633Aeromonas veronii B565 chromosome, complete genomeRnfABCDGE type electron transport complex subunit G5e-0650.8