Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1320105 Clostridium difficile 630, complete genome

Start: 1320105, End: 1320977, Length: 873

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012781:700226:700226700226701092867Eubacterium rectale ATCC 33656, complete genomephosphoesterase3e-44178
NC_014833:3667748:367945636794563680295840Ruminococcus albus 7 chromosome, complete genomemetallophosphoesterase2e-38159
NC_014614:260782:261615261615262424810Clostridium sticklandii, complete genomeMetallophosphoesterase precursor3e-37155
NC_007907:4692336:469233646923364693154819Desulfitobacterium hafniense Y51, complete genomehypothetical protein1e-34146
NC_015520:330500:346148346148347071924Mahella australiensis 50-1 BON chromosome, complete genomemetallophosphoesterase8e-25114
NC_007681:1608223:164821916482191649079861Methanosphaera stadtmanae DSM 3091, complete genomepredicted phosphohydrolase8e-25114
NC_000964:1474451:147637014763701477233864Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein5e-24111
NC_019896:2579036:259195925919592592819861Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completemetallophosphoesterase YkuE2e-23110
NC_015574:868000:871367871367872176810Methanobacterium sp. SWAN-1 chromosome, complete genomemetallophosphoesterase1e-22107
NC_014623:8648000:8669624866962486708321209Stigmatella aurantiaca DW4/3-1 chromosome, complete genomemetallophosphoesterase2e-1996.7
NC_015275:1573916:158368115836811584520840Clostridium lentocellum DSM 5427 chromosome, complete genomemetallophosphoesterase3e-1995.9
NC_011773:3547507:356767635676763568569894Bacillus cereus AH820 chromosome, complete genomeSer/Thr protein phosphatase family protein4e-1892.4
NC_012581:709234:709234709234710127894Bacillus anthracis str. CDC 684 chromosome, complete genomeSer/Thr protein phosphatase family protein5e-1892
NC_003909:3483244:350341035034103504303894Bacillus cereus ATCC 10987, complete genomeSer/Thr protein phosphatase family protein5e-1891.7
NC_010162:2469915:247620324762032477024822Sorangium cellulosum 'So ce 56', complete genomehypothetical protein2e-1789.7
NC_016776:3485688:3489596348959634907621167Bacteroides fragilis 638R, complete genomehypothetical protein3e-1789.4
NC_003228:3455405:3457885345788534590511167Bacteroides fragilis NCTC 9343, complete genomehypothetical protein3e-1789.4
NC_013851:2317091:232155923215592322500942Allochromatium vinosum DSM 180 chromosome, complete genomemetallophosphoesterase2e-1583.2
NC_018515:4474000:447550644755064476441936Desulfosporosinus meridiei DSM 13257 chromosome, complete genomephosphohydrolase2e-1583.2
NC_004663:2509433:2528100252810025291551056Bacteroides thetaiotaomicron VPI-5482, complete genomeputative phosphohydrolase5e-1582
NC_014221:554764:564291564291565160870Truepera radiovictrix DSM 17093 chromosome, complete genomemetallophosphoesterase1e-1377.4
NC_013517:104480:117397117397118254858Sebaldella termitidis ATCC 33386, complete genomemetallophosphoesterase2e-1376.6
NC_013192:1824174:182417418241741825016843Leptotrichia buccalis DSM 1135, complete genomemetallophosphoesterase2e-1376.6
NC_021182:1009526:102337110233711024183813Clostridium pasteurianum BC1, complete genomeputative phosphohydrolase3e-1375.9
NC_012988:1540587:1551139155113915522721134Methylobacterium extorquens DM4, complete genomeMetallophosphoesterase8e-1374.7
NC_011757:1246000:1256363125636312574961134Methylobacterium chloromethanicum CM4, complete genomemetallophosphoesterase1e-1273.9
NC_017030:8766757:8786962878696287881341173Corallococcus coralloides DSM 2259 chromosome, complete genomeserine/threonine protein phosphatase3e-1272.8
NC_000918:707801:728999728999729784786Aquifex aeolicus VF5, complete genomehypothetical protein2e-1272.8
NC_016935:4367000:4375163437516343762631101Paenibacillus mucilaginosus 3016 chromosome, complete genomephosphoesterase3e-1272.4
NC_011999:728353:756841756841757722882Macrococcus caseolyticus JCSC5402, complete genomehypothetical protein7e-1271.6
NC_009850:413093:435700435700436431732Arcobacter butzleri RM4018, complete genomeSer/Thr protein phosphatase family protein8e-1271.2
NC_010172:1222150:1229266122926612303991134Methylobacterium extorquens PA1, complete genomemetallophosphoesterase8e-1271.2
NC_003909:1205605:1223412122341212244851074Bacillus cereus ATCC 10987, complete genomeSer/Thr protein phosphatase family protein1e-1170.5
NC_007952:1293024:1315932131593213170951164Burkholderia xenovorans LB400 chromosome 2, complete sequenceSer/Thr protein phosphatase8e-1167.8
NC_014759:681172:7010077010077022631257Marivirga tractuosa DSM 4126 chromosome, complete genomemetallophosphoesterase1e-1067
NC_016616:2219486:2222198222219822233911194Dechlorosoma suillum PS chromosome, complete genomeputative phosphohydrolase1e-1067
NC_010676:897801:9178589178589190211164Burkholderia phytofirmans PsJN chromosome 2, complete sequencemetallophosphoesterase8e-1064.7
NC_014650:2097900:212256621225662123411846Geobacillus sp. Y4.1MC1 chromosome, complete genomemetallophosphoesterase1e-0963.9
NC_016627:1485799:153028815302881531094807Clostridium clariflavum DSM 19732 chromosome, complete genomeputative phosphohydrolase3e-0962.8
NC_014011:962474:9828919828919840481158Aminobacterium colombiense DSM 12261 chromosome, complete genomemetallophosphoesterase2e-0860.1
NC_013790:583474:5868545868545879541101Methanobrevibacter ruminantium M1 chromosome, complete genomecalcineurin-like phosphoesterase1e-0757.4
NC_014655:851381:8725528725528737991248Leadbetterella byssophila DSM 17132 chromosome, complete genome2e-0756.2
NC_008711:3701635:370638537063853707323939Arthrobacter aurescens TC1, complete genomeSer/Thr protein phosphatase family protein4e-0755.5
NC_014393:4988127:5005460500546050066051146Clostridium cellulovorans 743B chromosome, complete genomemetallophosphoesterase5e-0755.1