Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1318468 Clostridium difficile 630, complete genome

Start: 1318468, End: 1319370, Length: 903

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008563:4707826:472980647298064730723918Escherichia coli APEC O1, complete genomeputative pyruvate-formate lyase-activating enzyme3e-54212
NC_015573:2463123:250043325004332501374942Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeglycyl-radical enzyme activating protein family3e-52205
NC_021182:4058873:406031340603134061218906Clostridium pasteurianum BC1, complete genomeglycyl-radical enzyme activator family protein3e-51202
NC_015577:3621777:364344236434423644344903Treponema azotonutricium ZAS-9 chromosome, complete genomepyruvate formate-lyase-activating enzyme2e-47189
NC_009454:2502724:253056025305602531471912Pelotomaculum thermopropionicum SI, complete genomepyruvate-formate lyase-activating enzyme4e-47188
NC_012108:481657:495044495044495952909Desulfobacterium autotrophicum HRM2, complete genomePflC14e-45181
NC_016048:3856665:387205538720553872969915Oscillibacter valericigenes Sjm18-20, complete genomeglycyl-radical enzyme activating family protein6e-44177
NC_021184:657093:657093657093658031939Desulfotomaculum gibsoniae DSM 7213, complete genomeglycyl-radical enzyme activator family protein1e-43176
NC_009922:2556033:257209025720902573040951Alkaliphilus oremlandii OhILAs, complete genomeglycyl-radical enzyme activating protein family1e-43176
NC_021184:657093:670474670474671469996Desulfotomaculum gibsoniae DSM 7213, complete genomeglycyl-radical enzyme activator family protein7e-43174
NC_021182:966839:969602969602970534933Clostridium pasteurianum BC1, complete genomeglycyl-radical enzyme activator family protein1e-42173
NC_009438:212476:226933226933227853921Shewanella putrefaciens CN-32 chromosome, complete genomeglycyl-radical activating family protein2e-42173
NC_008750:450233:464493464493465413921Shewanella sp. W3-18-1, complete genomeglycyl-radical enzyme activating protein family2e-42173
NC_020063:3690308:371903437190343720008975Enterobacteriaceae bacterium strain FGI 57, complete genomeglycyl-radical enzyme activator family protein2e-42172
NC_021182:4058873:406569240656924066615924Clostridium pasteurianum BC1, complete genomeglycyl-radical enzyme activator family protein4e-42172
NC_009495:2244774:225435722543572255319963Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeglycyl-radical activating family protein1e-41170
NC_009698:2171151:218321821832182184171954Clostridium botulinum A str. Hall chromosome, complete genomeglycyl-radical enzyme activating family protein1e-41170
NC_009697:2173000:218299921829992183952954Clostridium botulinum A str. ATCC 19397 chromosome, completeglycyl-radical enzyme activating family protein1e-41170
NC_012658:2295536:231172723117272312680954Clostridium botulinum Ba4 str. 657 chromosome, complete genomeglycyl-radical enzyme activating family protein2e-41169
NC_009699:2287893:230355823035582304511954Clostridium botulinum F str. Langeland chromosome, complete genomeglycyl-radical enzyme activating family protein2e-41169
NC_012563:2384500:239776123977612398714954Clostridium botulinum A2 str. Kyoto, complete genomeglycyl-radical enzyme activating family protein2e-41169
NC_014364:4488875:450773445077344508657924Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeglycyl-radical enzyme activating protein family6e-41167
NC_008751:607209:624617624617625540924Desulfovibrio vulgaris subsp. vulgaris DP4, complete genomeglycyl-radical enzyme activating protein family6e-41167
NC_002937:2933000:293303029330302933953924Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough, completepyruvate formate-lyase 1 activating enzyme, putative8e-41167
NC_010723:1465097:147619614761961477149954Clostridium botulinum E3 str. Alaska E43, complete genomeglycyl-radical enzyme activating family protein1e-40167
NC_004557:1553000:156226215622621563224963Clostridium tetani E88, complete genomebenzylsuccinate synthase activating enzyme7e-40164
NC_009615:919495:924724924724925629906Parabacteroides distasonis ATCC 8503 chromosome, complete genomepyruvate-formate lyase-activating enzyme2e-39163
NC_010674:1496500:150598315059831506936954Clostridium botulinum B str. Eklund 17B, complete genomebenzylsuccinate synthase activating enzyme2e-39162
NC_014363:114239:141718141718142665948Olsenella uli DSM 7084 chromosome, complete genomeglycyl-radical enzyme activating protein family3e-38159
NC_016584:5625975:563927856392785640246969Desulfosporosinus orientis DSM 765 chromosome, complete genomeglycyl-radical enzyme activator family protein6e-38157
NC_010001:1745089:175808817580881759035948Clostridium phytofermentans ISDg, complete genomeglycyl-radical enzyme activating protein family3e-35149
NC_014328:2872721:287420728742072875118912Clostridium ljungdahlii ATCC 49587 chromosome, complete genomepyruvate formate-lyase activating enzyme2e-35149
NC_014328:4316008:432998643299864330936951Clostridium ljungdahlii ATCC 49587 chromosome, complete genomepyruvate formate-lyase activating enzyme5e-35148
NC_009633:3933941:394874939487493949696948Alkaliphilus metalliredigens QYMF chromosome, complete genomeglycyl-radical activating family protein8e-34144
NC_012470:2021316:202131620213162022089774Streptococcus equi subsp. zooepidemicus, complete genomepyruvate formate-lyase activating enzyme2e-33142
NC_014393:1421122:142540714254071426303897Clostridium cellulovorans 743B chromosome, complete genomeRadical SAM domain-containing protein2e-29129
NC_015424:2917817:293754229375422938438897Aeromonas veronii B565 chromosome, complete genomepyruvate formate-lyase 2-activating enzyme3e-29129
NC_013364:928486:951505951505952404900Escherichia coli O111:H- str. 11128, complete genomeputative pyruvate formate lyase activating enzyme4e-29128
NC_013353:922937:947234947234948133900Escherichia coli O103:H2 str. 12009, complete genomepyruvate formate lyase activating enzyme4e-29128
AP010958:922937:947234947234948133900Escherichia coli O103:H2 str. 12009 DNA, complete genomepredicted pyruvate formate lyase activating enzyme4e-29128
NC_013517:2055071:205983920598392060660822Sebaldella termitidis ATCC 33386, complete genomeglycyl-radical enzyme activating protein family7e-29127
NC_014624:2297000:230867423086742309594921Eubacterium limosum KIST612 chromosome, complete genomeputative pyruvate-formate lyase-activating enzyme4e-28125
NC_010001:1488000:149196114919611492752792Clostridium phytofermentans ISDg, complete genomeglycyl-radical enzyme activating protein family4e-27122
NC_013410:1285857:129149512914951292271777Fibrobacter succinogenes subsp. succinogenes S85 chromosome,pyruvate formate-lyase activating enzyme2e-26120
NC_009012:1901492:190757919075791908421843Clostridium thermocellum ATCC 27405, complete genomeRadical SAM5e-25115
NC_019970:35985:607916079161519729Thermoanaerobacterium thermosaccharolyticum M0795, complete genomepyruvate formate-lyase 1-activating enzyme4e-25115
NC_014410:51711:749047490475632729Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,pyruvate formate-lyase activating enzyme4e-25115
NC_014614:2500301:252580225258022526560759Clostridium sticklandii, complete genomepyruvate formate lyase activating enzyme 11e-24114
NC_016627:1960097:197152619715261972368843Clostridium clariflavum DSM 19732 chromosome, complete genomeglycine radical enzyme activase, YjjW family7e-24111
NC_015555:49842:739707397074698729Thermoanaerobacterium xylanolyticum LX-11 chromosome, completepyruvate formate-lyase activating enzyme6e-23108
NC_016938:193000:211219211219211995777Melissococcus plutonius DAT561 chromosome 1, complete genomepyruvate formate-lyase activating enzyme1e-20100
NC_014933:2240000:224205322420532242778726Bacteroides helcogenes P 36-108 chromosome, complete genomepyruvate formate-lyase activating enzyme6e-2098.2
NC_015578:423000:423018423018423869852Treponema primitia ZAS-2 chromosome, complete genomeradical SAM8e-2097.8
NC_007712:1601499:162391816239181624658741Sodalis glossinidius str. 'morsitans', complete genomepyruvate formate-lyase 1 activating enzyme2e-1996.7
NC_015275:1223088:124302112430211243746726Clostridium lentocellum DSM 5427 chromosome, complete genomepyruvate formate-lyase activating enzyme3e-1995.9
NC_015061:1598920:160241216024121603209798Rahnella sp. Y9602 chromosome, complete genomepyruvate formate-lyase activating enzyme3e-1892.8
NC_016818:1605918:160938716093871610184798Rahnella aquatilis CIP 78.65 = ATCC 33071 chromosome, completepyruvate formate-lyase activating enzyme3e-1892.8
NC_017047:1551836:155532815553281556068741Rahnella aquatilis HX2 chromosome, complete genomepyruvate formate lyase-activating enzyme 13e-1892.4
NC_004347:3028000:304450830445083045248741Shewanella oneidensis MR-1, complete genomepyruvate formate-lyase 1 activating enzyme4e-1892
NC_015500:311845:324489324489325265777Treponema brennaborense DSM 12168 chromosome, complete genome(Formate-C-acetyltransferase)-activating enzyme4e-1892
NC_010159:1668795:167164316716431672377735Yersinia pestis Angola, complete genomepyruvate formate-lyase 1-activating enzyme4e-1892
NC_014376:317312:336200336200336973774Clostridium saccharolyticum WM1 chromosome, complete genomepyruvate formate-lyase activating enzyme3e-1789.4
NC_011094:1050700:106119810611981061995798Salmonella enterica subsp. enterica serovar Schwarzengrund strpyruvate formate lyase-activating enzyme 15e-1788.6
NC_013093:2633000:267457826745782675423846Actinosynnema mirum DSM 43827, complete genomepyruvate formate-lyase activating enzyme6e-1788.2
NC_013716:5141269:516390851639085164771864Citrobacter rodentium ICC168, complete genomeradical SAM superfamily protein8e-1787.8
NC_015460:418826:434556434556435296741Gallibacterium anatis UMN179 chromosome, complete genomepyruvate formate lyase-activating enzyme 11e-1687
NC_009801:995396:9998659998651000662798Escherichia coli E24377A, complete genomepyruvate formate-lyase 1-activating enzyme2e-1687
NC_014033:1808782:183079218307921831628837Prevotella ruminicola 23 chromosome, complete genomeradical SAM domain-containing protein3e-1685.9
NC_018750:3315309:332659433265943327406813Streptomyces venezuelae ATCC 10712, complete genomePyruvate formate-lyase activating enzyme3e-1685.9
NC_014618:4010689:404083540408354041698864Enterobacter cloacae SCF1 chromosome, complete genomeradical SAM protein4e-1685.5
NC_009831:2045811:204581120458112046551741Shewanella sediminis HAW-EB3, complete genome(Formate-C-acetyltransferase)-activating enzyme9e-1684.3
NC_015709:1769806:179812517981251798919795Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completepyruvate formate-lyase activating enzyme1e-1583.6
NC_010001:3421710:344193634419363442688753Clostridium phytofermentans ISDg, complete genomepyruvate formate-lyase activating enzyme2e-1582.8
NC_006448:1451729:145231514523151453115801Streptococcus thermophilus LMG 18311, complete genomepyruvate-formate lyase activating enzyme4e-1479
NC_008618:1206157:122747812274781228356879Bifidobacterium adolescentis ATCC 15703, complete genomepyruvate formate-lyase 1 activating enzyme2e-1376.3
NC_013714:1521404:154305415430541543935882Bifidobacterium dentium Bd1, complete genomepflA1 Pyruvate formate-lyase activating enzyme2e-1273.2
NC_004603:1464000:146656414665641467445882Vibrio parahaemolyticus RIMD 2210633 chromosome I, completepyruvate formate lyase activating enzyme8e-1271.2
NC_004461:205068:205068205068205823756Staphylococcus epidermidis ATCC 12228, complete genomeformate acetyltransferase activating enzyme1e-1067.4
NC_014364:2717865:2723648272364827246611014Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeRadical SAM domain protein1e-1067.4
NC_017343:224777:227049227049227804756Staphylococcus aureus subsp. aureus ECT-R 2, complete genomepyruvate formate-lyase activating enzyme2e-1066.6
NC_016605:233087:236623236623237444822Pediococcus claussenii ATCC BAA-344 chromosome, complete genomepyruvate formate-lyase activating enzyme5e-1065.5