Pre_GI: BLASTP Hits

Some Help

Query: NC_009089:1283000:1316081 Clostridium difficile 630, complete genome

Start: 1316081, End: 1318453, Length: 2373

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009633:3933941:3949827394982739523642538Alkaliphilus metalliredigens QYMF chromosome, complete genomeformate C-acetyltransferase1e-178627
NC_004557:1553000:1563237156323715657772541Clostridium tetani E88, complete genomeformate acetyltransferase 21e-176620
NC_021182:4058873:4061331406133140637512421Clostridium pasteurianum BC1, complete genomepyruvate formate-lyase2e-175616
NC_020063:3690308:3716693371669337190712379Enterobacteriaceae bacterium strain FGI 57, complete genomepyruvate-formate lyase4e-174612
NC_014328:4316008:4331070433107043336192550Clostridium ljungdahlii ATCC 49587 chromosome, complete genomepyruvate formate-lyase2e-173610
NC_012658:2295536:2312844231284423153842541Clostridium botulinum Ba4 str. 657 chromosome, complete genomeformate acetyltransferase1e-172607
NC_010723:1465097:1473488147348814760282541Clostridium botulinum E3 str. Alaska E43, complete genomeformate C-acetyltransferase6e-172604
NC_012563:2384500:2398878239887824014182541Clostridium botulinum A2 str. Kyoto, complete genomeformate acetyltransferase1e-171603
NC_010001:1745089:1755519175551917580652547Clostridium phytofermentans ISDg, complete genomeFormate C-acetyltransferase2e-171603
NC_010674:1496500:1503275150327515058152541Clostridium botulinum B str. Eklund 17B, complete genomeformate C-acetyltransferase4e-171602
NC_016584:5625975:5640307564030756428502544Desulfosporosinus orientis DSM 765 chromosome, complete genomepyruvate-formate lyase8e-171601
NC_009495:2244774:2255474225547422580142541Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeformate acetyltransferase5e-171601
NC_009697:2173000:2184116218411621866562541Clostridium botulinum A str. ATCC 19397 chromosome, completeformate acetyltransferase5e-171601
NC_009698:2171151:2184335218433521868752541Clostridium botulinum A str. Hall chromosome, complete genomeformate acetyltransferase5e-171601
NC_009699:2287893:2304693230469323072332541Clostridium botulinum F str. Langeland chromosome, complete genomeformate acetyltransferase5e-171601
NC_017297:2288000:2304809230480923073492541Clostridium botulinum F str. 230613 chromosome, complete genomeformate acetyltransferase5e-171601
NC_009922:2556033:2573187257318725757362550Alkaliphilus oremlandii OhILAs, complete genomeFormate C-acetyltransferase2e-167590
NC_015573:2463123:2501489250148925039782490Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeFormate C-acetyltransferase3e-152539
NC_014328:2872721:2875133287513328774872355Clostridium ljungdahlii ATCC 49587 chromosome, complete genomepyruvate formate-lyase7e-145514
NC_021182:966839:9668399668399693252487Clostridium pasteurianum BC1, complete genomepyruvate-formate lyase2e-144513
NC_008750:450233:4655524655524680952544Shewanella sp. W3-18-1, complete genomepyruvate formate-lyase7e-140498
NC_009438:212476:2279922279922305352544Shewanella putrefaciens CN-32 chromosome, complete genomepyruvate formate-lyase7e-140498
NC_012108:481657:4926674926674950332367Desulfobacterium autotrophicum HRM2, complete genomePflD13e-138493
NC_009615:919495:9222889222889247202433Parabacteroides distasonis ATCC 8503 chromosome, complete genomeformate C-acetyltransferase2e-134479
NC_008751:607209:6257176257176282032487Desulfovibrio vulgaris subsp. vulgaris DP4, complete genomeFormate C-acetyltransferase9e-134478
NC_014624:2297000:2309569230956923119532385Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein4e-131469
NC_008023:1707021:1728268172826817306852418Streptococcus pyogenes MGAS2096, complete genomeFormate acetyltransferase5e-128459
NC_011134:1854868:1873022187302218754392418Streptococcus equi subsp. zooepidemicus str. MGCS10565, completepyruvate formate-lyase3e-128459
NC_002737:1670164:1705477170547717078942418Streptococcus pyogenes M1 GAS, complete genomeputative pyruvate formate-lyase 21e-127457
NC_014363:1344768:1367739136773913701532415Olsenella uli DSM 7084 chromosome, complete genomepyruvate formate-lyase1e-127457
NC_016048:3856665:3869661386966138720362376Oscillibacter valericigenes Sjm18-20, complete genomepyruvate formate-lyase family protein3e-125449
NC_013517:2055071:2057425205742520597222298Sebaldella termitidis ATCC 33386, complete genomepyruvate formate-lyase1e-120434
AP010958:922937:9447969447969472282433Escherichia coli O103:H2 str. 12009 DNA, complete genomepredicted pyruvate formate lyase2e-118427
NC_013353:922937:9447969447969472282433Escherichia coli O103:H2 str. 12009, complete genomepyruvate formate lyase2e-118427
NC_013364:928486:9490679490679514992433Escherichia coli O111:H- str. 11128, complete genomeputative pyruvate formate lyase2e-118427
NC_014364:4488875:4505347450534745076892343Spirochaeta smaragdinae DSM 11293 chromosome, complete genomepyruvate formate-lyase4e-118426
NC_006138:656000:6722656722656746162352Desulfotalea psychrophila LSv54, complete genomeformate C-acetyltransferase3e-117423
NC_016938:193000:2130022130022154342433Melissococcus plutonius DAT561 chromosome 1, complete genomepyruvate formate-lyase2e-115417
NC_015424:2917817:2938443293844329408782436Aeromonas veronii B565 chromosome, complete genomeformate acetyltransferase 32e-115417
NC_004431:4270305:4315437431543743179892553Escherichia coli CFT073, complete genomehypothetical protein3e-104380
NC_010001:1488000:1489322148932214919252604Clostridium phytofermentans ISDg, complete genomepyruvate formate-lyase4e-102372
NC_009943:1043210:1060198106019810625462349Candidatus Desulfococcus oleovorans Hxd3, complete genomeFormate C-acetyltransferase2e-97357
NC_021184:657093:6648106648106674102601Desulfotomaculum gibsoniae DSM 7213, complete genomepyruvate-formate lyase6e-86319
NC_021182:4058873:4066627406662740689902364Clostridium pasteurianum BC1, complete genomepyruvate-formate lyase3e-82307
NC_014363:114239:1374171374171400532637Olsenella uli DSM 7084 chromosome, complete genomeFormate C-acetyltransferase9e-82305
NC_015577:3621777:3644332364433236465362205Treponema azotonutricium ZAS-9 chromosome, complete genomeputative formate C-acetyltransferase5e-81302
NC_014365:3123853:3150612315061231527742163Desulfarculus baarsii DSM 2075 chromosome, complete genomeFormate C-acetyltransferase5e-56219
NC_017030:6558624:6573024657302465769503927Corallococcus coralloides DSM 2259 chromosome, complete genomehypothetical protein2e-52208
NC_017343:224777:2247772247772270262250Staphylococcus aureus subsp. aureus ECT-R 2, complete genomeformate acetyltransferase2e-48194
NC_015555:49842:7171371713739412229Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeformate acetyltransferase9e-48192
NC_019970:35985:5853358533607612229Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeformate acetyltransferase 15e-46186
NC_013093:2633000:2675503267550326777612259Actinosynnema mirum DSM 43827, complete genomeformate acetyltransferase2e-45184
NC_015977:442493:4755774755774778052229Roseburia hominis A2-183 chromosome, complete genomeformate acetyltransferase2e-45184
NC_015709:1769806:1795826179582617981412316Zymomonas mobilis subsp. pomaceae ATCC 29192 chromosome, completeformate acetyltransferase5e-44179
NC_015275:1223088:1243865124386512460932229Clostridium lentocellum DSM 5427 chromosome, complete genomeformate acetyltransferase5e-43176
NC_014393:1421122:1422831142283114253922562Clostridium cellulovorans 743B chromosome, complete genomeFormate C-acetyltransferase1e-41171
NC_018750:3315309:3327502332750233297812280Streptomyces venezuelae ATCC 10712, complete genomePyruvate formate-lyase2e-41171
NC_017068:1216548:1233793123379312360242232Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative pyruvate formate-lyase1e-40169
NC_014614:2500301:2523531252353125257742244Clostridium sticklandii, complete genomepyruvate formate lyase I8e-40166
NC_016605:233087:2343352343352365932259Pediococcus claussenii ATCC BAA-344 chromosome, complete genomeformate acetyltransferase2e-39164
NC_013410:1285857:1287270128727012895252256Fibrobacter succinogenes subsp. succinogenes S85 chromosome,formate acetyltransferase1e-38162
NC_011094:1050700:1063602106360210658842283Salmonella enterica subsp. enterica serovar Schwarzengrund strformate acetyltransferase3e-38160
NC_009801:995396:1017186101718610194682283Escherichia coli E24377A, complete genomeformate acetyltransferase7e-37156
NC_003295:1654000:1655952165595216600074056Ralstonia solanacearum GMI1000, complete genomehypothetical protein2e-36154
NC_007712:1601499:1624825162482516271072283Sodalis glossinidius str. 'morsitans', complete genomeformate acetyltransferase 15e-35150
NC_014618:586240:6080576080576103512295Enterobacter cloacae SCF1 chromosome, complete genomeformate acetyltransferase5e-34146
NC_014033:1808782:1831615183161518336091995Prevotella ruminicola 23 chromosome, complete genomepyruvate formate lyase family protein4e-33144
NC_009831:2045811:2046645204664520489272283Shewanella sediminis HAW-EB3, complete genomeFormate C-acetyltransferase1e-32142
NC_015500:311845:3224593224593244922034Treponema brennaborense DSM 12168 chromosome, complete genomeFormate C-acetyltransferase3e-32140
NC_014933:2240000:2242892224289222451292238Bacteroides helcogenes P 36-108 chromosome, complete genomeformate acetyltransferase5e-32140
NC_008258:3224721:3226560322656032288542295Shigella flexneri 5 str. 8401, complete genomeprobable formate acetyltransferase 31e-31139
NC_002695:3994970:3999753399975340020472295Escherichia coli O157:H7 str. Sakai, complete genomeputative formate acetyltransferase 31e-31139
NC_011751:3710786:3715570371557037178642295Escherichia coli UMN026 chromosome, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31139
NC_011750:3768692:3773475377347537757692295Escherichia coli IAI39 chromosome, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31139
NC_004337:3249791:3251630325163032539242295Shigella flexneri 2a str. 301, complete genomeprobable formate acetyltransferase 31e-31139
NC_004741:3240909:3242748324274832450422295Shigella flexneri 2a str. 2457T, complete genomeprobable formate acetyltransferase 31e-31139
NC_017328:3289853:3291692329169232939862295Shigella flexneri 2002017 chromosome, complete genomeKeto-acid formate acetyltransferase1e-31139
NC_013714:1521404:1544052154405215464272376Bifidobacterium dentium Bd1, complete genomepfl Formate acetyltransferase1e-31139
NC_008618:1206157:1228494122849412308692376Bifidobacterium adolescentis ATCC 15703, complete genomeformate acetyltransferase8e-32139
NC_010498:3488513:3490352349035234926462295Escherichia coli SMS-3-5, complete genomeformate acetyltransferase6e-32139
NC_011748:3608917:3613700361370036159942295Escherichia coli 55989, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_009800:3307123:3308962330896233112562295Escherichia coli HS, complete genomeformate acetyltransferase1e-31138
AC_000091:3258377:3258780325878032610742295Escherichia coli W3110 DNA, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
CP002185:3475991:3477828347782834801222295Escherichia coli W, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_000913:3256307:3258146325814632604402295Escherichia coli K12, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_010468:613812:6281426281426304362295Escherichia coli ATCC 8739, complete genomeformate acetyltransferase1e-31138
NC_010658:3014371:3024716302471630270102295Shigella boydii CDC 3083-94, complete genomeformate acetyltransferase2e-31138
NC_009801:3595001:3595001359500135972952295Escherichia coli E24377A, complete genomeformate acetyltransferase2e-31138
CP002516:613462:6259516259516282452295Escherichia coli KO11, complete genomeformate acetyltransferase1e-31138
CU928160:3344746:3346585334658533488792295Escherichia coli IAI1 chromosome, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_010473:3354052:3355891335589133581852295Escherichia coli str. K-12 substr. DH10B, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_016902:613462:6259516259516282452295Escherichia coli KO11FL chromosome, complete genomeformate acetyltransferase1e-31138
NC_013941:3884725:3889508388950838918022295Escherichia coli O55:H7 str. CB9615 chromosome, complete genomeKeto-acid formate acetyltransferase1e-31138
NC_012967:3191319:3193158319315831954522295Escherichia coli B str. REL606 chromosome, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_012947:630757:6450876450876473812295Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completeformate acetyltransferase1e-31138
NC_012759:3143455:3145294314529431475882295Escherichia coli BW2952 chromosome, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_011741:3344746:3346585334658533488792295Escherichia coli IAI1 chromosome, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_011415:3523364:3528147352814735304412295Escherichia coli SE11 chromosome, complete genomeputative formate acetyltransferase 31e-31138
CU928145:3608917:3613700361370036159942295Escherichia coli 55989 chromosome, complete genomepyruvate formate-lyase 4/2-ketobutyrate formate-lyase1e-31138
NC_004347:3028000:3042162304216230444442283Shewanella oneidensis MR-1, complete genomeformate acetyltransferase2e-31137
NC_007613:2981829:2982232298223229845262295Shigella boydii Sb227, complete genomeprobable formate acetyltransferase 33e-31137
NC_014376:317312:3375993375993396592061Clostridium saccharolyticum WM1 chromosome, complete genomeformate acetyltransferase6e-26120
NC_010001:3421710:3443643344364334457032061Clostridium phytofermentans ISDg, complete genomeformate acetyltransferase9e-23109
NC_014376:317312:336997336997337242246Clostridium saccharolyticum WM1 chromosome, complete genomeformate C-acetyltransferase glycine radical3e-1274.3
NC_008527:611836:6316816316816340442364Lactococcus lactis subsp. cremoris SK11, complete genomePyruvate-formate lyase7e-1273.2
NC_010001:3421710:344307534430753443323249Clostridium phytofermentans ISDg, complete genomeformate C-acetyltransferase glycine radical7e-1170.1
NC_014410:51711:7264772647748742228Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,7e-0756.6