Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1312709 Clostridium difficile 630, complete genome

Start: 1312709, End: 1313185, Length: 477

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014169:1442435:145218414521841452660477Bifidobacterium longum subsp. longum JDM301 chromosome, completehypothetical protein2e-31134
NC_018867:10238:253082530825793486Dehalobacter sp. CF chromosome, complete genomehypothetical protein4e-23107
NC_015977:3324000:333179933317993332275477Roseburia hominis A2-183 chromosome, complete genomehypothetical protein5e-23106
NC_004668:2198027:225443322544332254912480Enterococcus faecalis V583, complete genomehypothetical protein8e-1992.8
NC_016630:434500:448941448941449423483Filifactor alocis ATCC 35896 chromosome, complete genomehypothetical protein1e-1685.9
NC_002967:2194829:220639022063902206614225Treponema denticola ATCC 35405, complete genomehypothetical protein1e-1169.3
NC_014376:317312:320317320317320790474Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein2e-0961.2
NC_009706:238160:259001259001259474474Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-0960.5
NC_012781:2552723:256440825644082564878471Eubacterium rectale ATCC 33656, complete genomehypothetical protein2e-0858.5
NC_012781:700226:733881733881734351471Eubacterium rectale ATCC 33656, complete genomehypothetical protein2e-0858.5
NC_015975:558523:564291564291564776486Lactobacillus ruminis ATCC 27782 chromosome, complete genomehypothetical protein5e-0650.1