Pre_GI: BLASTP Hits

Some Help

Query: NC_009089:1283000:1310925 Clostridium difficile 630, complete genome

Start: 1310925, End: 1312712, Length: 1788

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018867:10238:2579025790275651776Dehalobacter sp. CF chromosome, complete genomehypothetical protein0888
NC_014169:1442435:1452669145266914544621794Bifidobacterium longum subsp. longum JDM301 chromosome, completehypothetical protein0884
NC_009089:478328:4830724830724848561785Clostridium difficile 630, complete genomeputative conjugal transfer protein0840
NC_004668:2198027:2252661225266122544361776Enterococcus faecalis V583, complete genomeTraG family protein0769
NC_016630:434500:4471844471844489441761Filifactor alocis ATCC 35896 chromosome, complete genomeTraG family protein0742
NC_014376:317312:3184953184953203271833Clostridium saccharolyticum WM1 chromosome, complete genome0697
NC_009706:238160:2571792571792590111833Clostridium kluyveri DSM 555 chromosome, complete genomeplasmid transfer factor-like protein0693
NC_011837:238160:2571792571792590711893Clostridium kluyveri NBRC 12016, complete genomehypothetical protein0692
NC_015977:3324000:3330762333076233318021041Roseburia hominis A2-183 chromosome, complete genomeconjugal transfer protein3e-132472
NC_012781:2552723:2567773256777325690801308Eubacterium rectale ATCC 33656, complete genomeATPase involved in conjugal plasmid transfer8e-123441
NC_012781:700226:7296797296797309861308Eubacterium rectale ATCC 33656, complete genomeATPase involved in conjugal plasmid transfer8e-123441
NC_008023:1070986:1082250108225010840431794Streptococcus pyogenes MGAS2096, complete genomeTraG/TraD family3e-112406
NC_014246:57021:8101881018828591842Mobiluncus curtisii ATCC 43063 chromosome, complete genomeTraG/TraD family protein6e-108391
NC_015977:3424178:3507521350752135096982178Roseburia hominis A2-183 chromosome, complete genomeTraG/TraD family protein6e-101368
NC_015052:1313311:1349250134925013510851836Bifidobacterium longum subsp. infantis 157F, complete genomehypothetical protein6e-92338
NC_004116:1276791:1304689130468913065061818Streptococcus agalactiae 2603V/R, complete genome6e-85315
NC_004368:1160535:1173758117375811758182061Streptococcus agalactiae NEM316, complete genomehypothetical protein4e-76286
NC_020450:1254849:1254849125484912567051857Lactococcus lactis subsp. lactis IO-1 DNA, complete genomeconjugal transfer protein TraD5e-73275
NC_016048:2343500:234786723478672348670804Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein4e-64246
NC_003869:1971766:1982399198239919844022004Thermoanaerobacter tengcongensis MB4, complete genomeATPase involved in conjugal plasmid transfer7e-61235
NC_012781:2552723:256487525648752565528654Eubacterium rectale ATCC 33656, complete genomeTraG protein5e-60232
NC_012781:700226:733231733231733884654Eubacterium rectale ATCC 33656, complete genomeTraG protein5e-60232
NC_007644:362000:3679313679313699161986Moorella thermoacetica ATCC 39073, complete genomeTRAG protein4e-59229
NC_006087:765081:7678797678797697231845Leifsonia xyli subsp. xyli str. CTCB07, complete genomeconjugal plasmid transfer, ATPase3e-53210
NC_012654:170956:1875941875941895401947Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequenceATPase involved in conjugal plasmid transfer5e-53209
NC_014652:379833:3913543913543932311878Caldicellulosiruptor hydrothermalis 108 chromosome, completetrag family protein2e-52207
NC_012034:2623252:2641160264116026430371878Anaerocellum thermophilum DSM 6725, complete genomeTRAG family protein2e-51204
NC_014721:2201790:2213725221372522156381914Caldicellulosiruptor kristjanssonii 177R1B chromosome, completetrag family protein2e-49197
NC_015589:3813415:3815476381547638174491974Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeTRAG family protein4e-48192
NC_015603:1:1070110701122211521Lactobacillus kefiranofaciens ZW3 plasmid pWW2, complete sequenceprotein Trs1e-46188
NC_012891:1277966:129077812907781291107330Streptococcus dysgalactiae subsp. equisimilis GGS_124 chromosome 1,hypothetical protein9e-43175
NC_009437:2815500:2820624282062428225101887Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeTRAG family protein7e-42172
NC_009437:1556934:1568309156830915701471839Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeTRAG family protein2e-41171
NC_009253:1031799:1031799103179910345372739Desulfotomaculum reducens MI-1 chromosome, complete genomeTRAG family protein2e-33144
NC_011593:1202726:121828412182841218889606Bifidobacterium longum subsp. infantis ATCC 15697 chromosome,8e-32139
NC_010321:35855:4888548885507171833Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeTRAG family protein1e-29131
NC_014964:35862:4889248892507241833Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completeTRAG family protein1e-29131
NC_010337:616304:6198006198006216201821Heliobacterium modesticaldum Ice1, complete genometrag/trad family protein, putative6e-29129
NC_014624:1768226:1806146180614618082632118Eubacterium limosum KIST612 chromosome, complete genomeTraG/TraD family protein3e-25117
NC_016048:4163225:4199650419965042014521803Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein4e-23110
NC_016791:3891272:3914625391462539164421818Clostridium sp. BNL1100 chromosome, complete genometype IV secretory pathway, VirD4 component2e-23110
NC_017219:1203500:121807512180751218491417Bifidobacterium longum subsp. infantis ATCC 15697, complete genomehypothetical protein2e-22107
NC_018867:1357540:1360767136076713625871821Dehalobacter sp. CF chromosome, complete genomeTRAG family protein5e-22106
NC_018866:1279000:1282227128222712840471821Dehalobacter sp. DCA chromosome, complete genomeTRAG family protein5e-22106
NC_007907:5185510:5263303526330352651201818Desulfitobacterium hafniense Y51, complete genomehypothetical protein9e-22105
NC_018870:757416:7824677824677843051839Thermacetogenium phaeum DSM 12270 chromosome, complete genomeTRAG-like protein9e-22105
NC_016791:3953972:3982848398284839846681821Clostridium sp. BNL1100 chromosome, complete genometype IV secretory pathway, VirD4 component8e-22105
NC_009706:3882500:3907598390759839094001803Clostridium kluyveri DSM 555 chromosome, complete genomeTraG-like protein7e-22105
NC_011837:3814000:3839101383910138409031803Clostridium kluyveri NBRC 12016, complete genomehypothetical protein7e-22105
NC_021184:3533500:3549757354975735515741818Desulfotomaculum gibsoniae DSM 7213, complete genometype IV secretory pathway, VirD4 component2e-21104
NC_014376:3009403:3033976303397630358231848Clostridium saccharolyticum WM1 chromosome, complete genomeTRAG family protein3e-21103
NC_013768:1802313:1818281181828118200831803Listeria monocytogenes 08-5923, complete genometype IV secretion system protein VirD47e-21102
NC_013766:1835964:1851550185155018533521803Listeria monocytogenes 08-5578 chromosome, complete genometype IV secretion system protein VirD47e-21102
NC_014816:1592799:1596795159679515984711677Asticcacaulis excentricus CB 48 chromosome 1, complete sequencetrag family protein2e-20101
NC_007907:960104:1031622103162210334421821Desulfitobacterium hafniense Y51, complete genomehypothetical protein2e-20100
NC_016814:18000:3264032640347392100Sinorhizobium fredii HH103 plasmid pSfHH103c complete sequenceProtein virD43e-1894
NC_014816:545441:5663965663965680721677Asticcacaulis excentricus CB 48 chromosome 1, complete sequencetrag family protein9e-1892.4
NC_016052:2038000:2040338204033820425752238Tetragenococcus halophilus NBRC 12172, complete genomehypothetical protein1e-1791.7
NC_009253:897684:8991758991759012232049Desulfotomaculum reducens MI-1 chromosome, complete genomeTRAG family protein2e-1688.2
NC_010999:561914:5862825862825887412460Lactobacillus casei, complete genomeTRAG protein precursor4e-1687
NC_015589:712626:7180157180157200752061Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeTRAG family protein3e-1584
NC_012891:1277966:129665412966541296992339Streptococcus dysgalactiae subsp. equisimilis GGS_124 chromosome 1,hypothetical protein3e-1377.4
NC_015259:3902136:3905033390503339071922160Polymorphum gilvum SL003B-26A1 chromosome, complete genomeTraG/TraD family protein3e-1377
NC_014910:2930860:2935496293549629375022007Alicycliphilus denitrificans BC chromosome, complete genometrag family protein7e-1376.3
NC_011987:53760:5376053760561232364Agrobacterium radiobacter K84 plasmid pAtK84c, complete sequenceTRAG protein1e-1275.1
NC_017249:18493:3729937299392811983Bradyrhizobium japonicum USDA 6, complete genomeconjugal transfer protein7e-1272.8
NC_006831:4500:1217012170145722403Ehrlichia ruminantium str. Gardel, complete genomePutative virD4 protein1e-1172
NC_005295:21995:3116531165335702406Ehrlichia ruminantium str. Welgevonden, complete genometype IV secretion system protein VirD41e-1172
NC_012416:4973:83058305103232019Wolbachia sp. wRi, complete genometype IV secretion system protein VirD41e-1171.6
NC_014414:1104386:1109337110933711111751839Parvularcula bermudensis HTCC2503 chromosome, complete genomehypothetical protein2e-1171.6
NC_014921:879228:9029359029359051542220Mycoplasma fermentans M64 chromosome, complete genomehypothetical protein2e-1171.2
NC_014921:481559:5049995049995072182220Mycoplasma fermentans M64 chromosome, complete genomehypothetical protein2e-1171.2
NC_007798:652317:6585716585716604961926Neorickettsia sennetsu str. Miyayama, complete genometype IV secretion system protein VirD42e-1171.2
NC_014921:830334:8366318366318388502220Mycoplasma fermentans M64 chromosome, complete genomehypothetical protein3e-1170.9
NC_014828:2657623:2665338266533826674762139Ethanoligenens harbinense YUAN-3 chromosome, complete genomeTRAG family protein3e-1170.9
NC_002978:4973:82698269102151947Wolbachia endosymbiont of Drosophila melanogaster, complete genometype IV secretion system protein VirD42e-1170.9
NC_004463:18497:3730537305393322028Bradyrhizobium japonicum USDA 110, complete genomeconjugal transfer protein2e-1170.9
NC_003295:2787371:2792029279202927940562028Ralstonia solanacearum GMI1000, complete genomePROBABLE PLASMID CONJUGATION TRAG TRANSMEMBRANE PROTEIN1e-1068.9
NC_009445:6621996:6633769663376966353851617Bradyrhizobium sp. ORS 278 chromosome, complete genomeVirD4/TraG family protein2e-1068.2
NC_015942:1947258:1965686196568619681812496Acidithiobacillus ferrivorans SS3 chromosome, complete genomeTRAG family protein2e-1068.2
NC_007797:1451804:1460198146019814624202223Anaplasma phagocytophilum HZ, complete genometype IV secretion system protein VirD45e-1066.6
NC_003902:2933121:2952459295245929541321674Xanthomonas campestris pv. campestris str. ATCC 33913, completeVirD4 protein1e-0965.5
NC_007086:1936505:1956087195608719577601674Xanthomonas campestris pv. campestris str. 8004, complete genomeVirD4 protein1e-0965.5
NC_009719:1972545:1984249198424919863122064Parvibaculum lavamentivorans DS-1 chromosome, complete genomeconjugal transfer coupling protein TraG2e-0964.7
NC_004842:1132441:1154957115495711573772421Anaplasma marginale str. St. Maries, complete genomeVirD4 protein3e-0964.3
NC_012026:1135041:1159067115906711614872421Anaplasma marginale str. Florida, complete genomeVirD4 protein (virD4)3e-0964.3
NC_010688:1908012:1928821192882119304941674Xanthomonas campestris pv. campestris, complete genometype IV secretion system coupling protein VirD42e-0964.3
NC_013532:85371:8641786417888432427Anaplasma centrale str. Israel, complete genometype IV secretion system protein VirD42e-0964.3
NC_017271:2935643:2973196297319629748631668Xanthomonas campestris pv. raphani 756C chromosome, completeVirD4 protein4e-0963.5
NC_003919:3060484:3088230308823030899031674Xanthomonas axonopodis pv. citri str. 306, complete genomeVirD4 protein6e-0963.2
NC_007508:3183631:3196116319611631977891674Xanthomonas campestris pv. vesicatoria str. 85-10, complete genometype IV secretion system protein VirD46e-0962.8
NC_016010:1822212:1863335186333518650321698Xanthomonas axonopodis pv. citrumelo F1 chromosome, completetype IV secretion system protein VirD43e-0860.8
NC_010338:2443765:2450624245062424523451722Caulobacter sp. K31, complete genomeTRAG family protein4e-0860.1
NC_009720:583060:6035036035036050321530Xanthobacter autotrophicus Py2, complete genomeTRAG family protein9e-0858.9
NC_007930:99693:1020071020071048712865Lactobacillus salivarius subsp. salivarius UCC118 plasmid pMP118,Conjugation-related ATPase9e-0858.9
NC_007086:2887875:2924209292420929259061698Xanthomonas campestris pv. campestris str. 8004, complete genomeputative NTPase VagA2e-0758.2
NC_017271:4058642:4069267406926740709701704Xanthomonas campestris pv. raphani 756C chromosome, completetype IV secretion system protein VirD43e-0757.8
NC_015942:722980:7396097396097418762268Acidithiobacillus ferrivorans SS3 chromosome, complete genomeTRAG family protein6e-0756.6
NC_017271:149856:1689951689951705751581Xanthomonas campestris pv. raphani 756C chromosome, completetype IV secretion system protein VirD41e-0655.8
NC_014332:1:1291112911147281818Bacillus cereus biovar anthracis str. CI plasmid pCI-XO2, completeTraG/TraF family conjugation protein1e-0655.5
NC_013132:7954000:7963702796370279654681767Chitinophaga pinensis DSM 2588, complete genomeTRAG family protein1e-0655.1
NC_007323:1:1188811888137231836Bacillus anthracis str. 'Ames Ancestor' plasmid pXO2, completeconjugation protein, trag/trad family, (pxo2-16)1e-0655.1
NC_010515:1124298:1127230112723011289421713Burkholderia cenocepacia MC0-3 chromosome 2, complete sequenceTRAG family protein3e-0654.3
NC_009254:365812:3745933745933763111719Burkholderia vietnamiensis G4 chromosome 3, complete sequenceTRAG family protein4e-0653.9
NC_008061:2106848:2109780210978021114531674Burkholderia cenocepacia AU 1054 chromosome 2, complete sequenceTRAG protein5e-0653.1
NC_006578:1:1148111481141142634Bacillus thuringiensis serovar konkukian str. 97-27 plasmidpossible conjugation protein6e-0653.1
NC_016609:4233701:4266867426686742688792013Niastella koreensis GR20-10 chromosome, complete genomeTRAG family protein9e-0652.4