Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1309464 Clostridium difficile 630, complete genome

Start: 1309464, End: 1310333, Length: 870

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012781:3315614:335205333520533352922870Eubacterium rectale ATCC 33656, complete genomehypothetical protein1e-110399
NC_018867:10238:278462784628715870Dehalobacter sp. CF chromosome, complete genomehypothetical protein4e-100364
NC_016630:434500:445944445944446813870Filifactor alocis ATCC 35896 chromosome, complete genomehypothetical protein8e-96350
NC_004668:2198027:224872822487282249597870Enterococcus faecalis V583, complete genomehypothetical protein6e-95347
NC_013316:2033906:208783320878332088696864Clostridium difficile R20291, complete genomeputative conjugative transposon membrane protein1e-82306
NC_009089:478328:485569485569486432864Clostridium difficile 630, complete genomehypothetical protein4e-82304
NC_012781:2552723:257984725798472580713867Eubacterium rectale ATCC 33656, complete genomehypothetical protein7e-82303
NC_012781:700226:718046718046718912867Eubacterium rectale ATCC 33656, complete genomehypothetical protein7e-82303
NC_013164:67500:689656896569828864Anaerococcus prevotii DSM 20548 plasmid pAPRE01, complete sequencehypothetical protein3e-81301
NC_014376:317312:317312317312318178867Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein2e-80298
NC_011837:238160:255996255996256862867Clostridium kluyveri NBRC 12016, complete genomehypothetical protein1e-79296
NC_009706:238160:255996255996256862867Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein1e-79296
NC_016048:3063888:306714830671483068011864Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein7e-78290
NC_012471:1197534:126311112631111263929819Streptococcus equi subsp. equi 4047, complete genomeconjugative transposon membrane protein7e-72270
NC_012471:719000:727682727682728035354Streptococcus equi subsp. equi 4047, complete genome5e-30131
NC_016048:2678205:270920127092012709500300Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-0964.3
NC_013204:989103:9891039891039901071005Eggerthella lenta DSM 2243, complete genomehypothetical protein2e-0756.6