Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1309038 Clostridium difficile 630, complete genome

Start: 1309038, End: 1309442, Length: 405

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011837:238160:254569254569254964396Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-28124
NC_009706:238160:254569254569254964396Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-28124
NC_004668:2198027:224640522464052246824420Enterococcus faecalis V583, complete genomehypothetical protein1e-27122
NC_016048:3063888:306557330655733065950378Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein7e-26115
NC_012781:3315614:335156533515653352029465Eubacterium rectale ATCC 33656, complete genomehypothetical protein4e-25113
NC_016630:434500:444963444963445358396Filifactor alocis ATCC 35896 chromosome, complete genomehypothetical protein2e-23107
NC_009089:478328:486717486717487106390Clostridium difficile 630, complete genomehypothetical protein2e-1477.4
NC_016630:1247251:129091112909111291300390Filifactor alocis ATCC 35896 chromosome, complete genomehypothetical protein8e-1475.9
NC_012471:719000:728334728334728723390Streptococcus equi subsp. equi 4047, complete genomeconjugative transposon membrane protein3e-1373.9
NC_013164:67500:701307013070540411Anaerococcus prevotii DSM 20548 plasmid pAPRE01, complete sequencehypothetical protein1e-1272
NC_012471:1197534:126213012621301262540411Streptococcus equi subsp. equi 4047, complete genomeconjugative transposon membrane protein5e-1166.6
NC_016048:2678205:270683827068382707005168Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein5e-0650.1