Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1306661 Clostridium difficile 630, complete genome

Start: 1306661, End: 1309090, Length: 2430

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018867:10238:2915829158314882331Dehalobacter sp. CF chromosome, complete genomeTrsE-like protein01144
NC_004668:2198027:2244004224400422464812478Enterococcus faecalis V583, complete genometraE protein, putative01121
NC_012781:3315614:3349227334922733514882262Eubacterium rectale ATCC 33656, complete genomehypothetical protein01104
NC_016630:434500:4425444425444450062463Filifactor alocis ATCC 35896 chromosome, complete genometype IV conjugative transfer system protein TraE01065
NC_016630:1247251:1288570128857012909632394Filifactor alocis ATCC 35896 chromosome, complete genometype IV conjugative transfer system protein TraE0928
NC_009089:478328:4870544870544894472394Clostridium difficile 630, complete genomeputative conjugal transfer protein0915
NC_013316:2033906:2089315208931520917082394Clostridium difficile R20291, complete genomeputative conjugal transfer protein0915
NC_012471:1197534:1259693125969312621192427Streptococcus equi subsp. equi 4047, complete genomeconjugal transfer protein0911
NC_012471:719000:7286357286357310642430Streptococcus equi subsp. equi 4047, complete genomeconjugal transfer protein0906
NC_009706:238160:2522582522582546212364Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein0900
NC_013164:67500:7061170611728542244Anaerococcus prevotii DSM 20548 plasmid pAPRE01, complete sequenceputative type IV secretory pathway VirB4 protein0892
NC_011837:238160:2522582522582545222265Clostridium kluyveri NBRC 12016, complete genomehypothetical protein0885
NC_012781:2552723:2583081258308125848381758Eubacterium rectale ATCC 33656, complete genomehypothetical protein0754
NC_012781:700226:7139217139217156781758Eubacterium rectale ATCC 33656, complete genomehypothetical protein0754
NC_018866:27878:4555845558478942337Dehalobacter sp. DCA chromosome, complete genomehypothetical protein4e-159562
NC_008023:1070986:1077345107734510797742430Streptococcus pyogenes MGAS2096, complete genomeTRSE protein9e-154544
NC_014624:224213:2242132242132265372325Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein6e-152538
NC_015738:3042000:3063295306329530656042310Eggerthella sp. YY7918, complete genomehypothetical protein3e-143509
NC_014246:57021:8641886418886402223Mobiluncus curtisii ATCC 43063 chromosome, complete genometransfer complex protein2e-132473
NC_015977:3424178:3501261350126135036392379Roseburia hominis A2-183 chromosome, complete genomeTRSE protein7e-122438
NC_006087:765081:7650817650817676062526Leifsonia xyli subsp. xyli str. CTCB07, complete genometransfer complex protein7e-120432
NC_004116:1276791:1300833130083313031632331Streptococcus agalactiae 2603V/R, complete genomeTn5252, Orf268e-114412
NC_004368:1386746:1413014141301414153742361Streptococcus agalactiae NEM316, complete genomehypothetical protein2e-112407
NC_016749:1371997:1394027139402713963752349Streptococcus macedonicus ACA-DC 198, complete genometrsE-like protein4e-112406
NC_004368:1160535:1181463118146311838652403Streptococcus agalactiae NEM316, complete genomehypothetical protein3e-95350
NC_021175:789958:8068378068378092002364Streptococcus oligofermentans AS 1.3089, complete genomehypothetical protein1e-92341
NC_016048:3063888:306472930647293065523795Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein4e-50200
NC_015312:1265797:1287412128741212893221911Pseudonocardia dioxanivorans CB1190 chromosome, complete genometype IV secretory pathway VirB4 components-like protein3e-36154
NC_013131:7889127:7910120791012079119461827Catenulispora acidiphila DSM 44928, complete genometype IV secretory pathway VirB4 protein-like protein3e-33144
NC_013131:9903320:9948989994898999507761788Catenulispora acidiphila DSM 44928, complete genometype IV secretory pathway VirB4 protein-like protein8e-28126
NC_009437:2815500:2832379283237928341511773Caldicellulosiruptor saccharolyticus DSM 8903, complete genomeAAA ATPase2e-26122
NC_016582:10159486:1016391410163914101657731860Streptomyces bingchenggensis BCW-1 chromosome, complete genometype IV secretory pathway VirB4 protein-like protein5e-26120
NC_014964:2272413:2285184228518422870191836Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completetype IV secretory pathway VirB4 components-like protein4e-25117
NC_014652:379833:3813053813053831641860Caldicellulosiruptor hydrothermalis 108 chromosome, completeaaa atpase5e-25117
NC_014391:1910273:1908453190845319102761824Micromonospora aurantiaca ATCC 27029 chromosome, complete genometype IV secretory pathway VirB4 protein-like protein1e-24115
NC_014538:2158131:2173861217386121756961836Thermoanaerobacter sp. X513 chromosome, complete genometype IV secretory pathway VirB4 components-like protein9e-25115
NC_016048:2678205:270642227064222706868447Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein8e-24112
NC_009921:8147947:8180935818093581829081974Frankia sp. EAN1pec, complete genomeType IV secretory pathway VirB4 protein-like protein3e-23110
NC_015434:2460053:2462503246250324642061704Verrucosispora maris AB-18-032 chromosome, complete genometype iv secretory pathway virb4 protein-like protein5e-23110
NC_010321:35855:5603356033578171785Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completeType IV secretory pathway VirB4 components-like protein9e-23109
NC_014964:35862:5604056040578241785Thermoanaerobacter brockii subsp. finnii Ako-1 chromosome, completetype IV secretory pathway VirB4 components-like protein9e-23109
NC_015603:1:4634463466522019Lactobacillus kefiranofaciens ZW3 plasmid pWW2, complete sequenceconjugal transfer protein Tra1e-21105
NC_014815:6616500:6688344668834466900951752Micromonospora sp. L5 chromosome, complete genometype iv secretory pathway virb4 protein-like protein1e-21105
NC_013926:1009718:1014731101473110164311701Aciduliprofundum boonei T469 chromosome, complete genomeType IV secretory pathway VirB4 protein-like protein8e-21103
NC_013849:376676:3905033905033923171815Ferroglobus placidus DSM 10642 chromosome, complete genomeType IV secretory pathway VirB4 protein-like protein2e-1895.5
NC_014721:2201790:2223973222397322258381866Caldicellulosiruptor kristjanssonii 177R1B chromosome, completeaaa atpase1e-1792.8
NC_011775:156673:1701331701331722232091Bacillus cereus G9842 plasmid pG9842_209, complete sequencehypothetical protein3e-1791.3
NC_015943:47000:5749357493598862394Haloarcula hispanica ATCC 33960 chromosome chromosome II, completeType IV secretory pathway VirB4 protein-like protein3e-1791.3
NC_011777:100631:1055611055611076602100Bacillus cereus AH820 plasmid pAH820_272, complete sequencehypothetical protein2e-1378.2
NC_005707:12735:2623726237283362100Bacillus cereus ATCC 10987 plasmid pBc10987, complete sequencehypothetical protein2e-1378.2
NC_015520:2567329:2587205258720525890491845Mahella australiensis 50-1 BON chromosome, complete genomeAAA ATPase6e-1376.6
NC_013792:109203:1244971244971265002004Bacillus pseudofirmus OF4 plasmid pBpOF4-01, complete sequencehypothetical protein1e-1276.3
NC_015589:3852217:3856599385659938584431845Desulfotomaculum ruminis DSM 2154 chromosome, complete genomehypothetical protein9e-1376.3
NC_015687:2145452:2156640215664021584931854Clostridium acetobutylicum DSM 1731 chromosome, complete genomeconjugative transfer TrsE , ATPase2e-1275.5
NC_012473:46000:7664576645787352091Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein2e-1275.1
NC_012656:67949:8962989629917282100Bacillus anthracis str. A0248 plasmid pXO1, complete sequence7e-1273.2
NC_007322:57710:8936589365914642100Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, complete7e-1273.2
NC_012579:72715:8968589685917842100Bacillus anthracis str. CDC 684 plasmid pX01, complete sequencehypothetical protein8e-1273.2
NC_014331:57769:8966189661917602100Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completehypothetical protein9e-1272.8
NC_017177:192933:2062232062232081451923Clostridium difficile BI1, complete genomeType IV secretory pathway VirB4 component-like protein1e-1172.8
NC_010381:35408:5125251252531471896Lysinibacillus sphaericus C3-41 plasmid pBsph, complete sequencehypothetical protein4e-1067.4
NC_009140:60806:8152081520839672448Salmonella enterica enterica sv Newport str. SL254, completetype IV conjugative transfer system protein TraC3e-0964.3
NC_014297:1037457:1047693104769310496451953Halalkalicoccus jeotgali B3 chromosome, complete genometransfer complex protein2e-0862
NC_013967:2103968:2144614214461421463801767Haloferax volcanii DS2 chromosome, complete genometransfer complex protein homolog5e-0860.5
NC_019964:2816990:2844630284463028479473318Halovivax ruber XH-70, complete genomehypothetical protein9e-0859.7
NC_015377:34445:3444534445370422598Burkholderia gladioli BSR3 plasmid bgla_2p, complete sequencehypothetical protein1e-0759.3
NC_017202:56000:630616306163882822Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT127,hypothetical protein2e-0655.5
NC_011035:829945:8787078787078812832577Neisseria gonorrhoeae NCCP11945 chromosome, complete genomeprotein TraC2e-0655.1
NC_016048:797762:8438798438798457081830Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein3e-0654.7