Pre_GI: BLASTP Hits

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Query: NC_009089:1283000:1303738 Clostridium difficile 630, complete genome

Start: 1303738, End: 1305678, Length: 1941

Host Lineage: Peptoclostridium difficile; Peptoclostridium; Peptostreptococcaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is the epidemic type X variant that has been extensively studied in research and clinical laboratories. It produces both toxin A, and B. Causative agent of pseudomembranous colitis. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This species is now recognized as the major causative agent of pseudomembranous colitis (inflammation of the colon) and diarrhea that may occur following antibiotic treatment. This bacterium causes a wide spectrum of disease, ranging from mild, self-limiting diarrhea to serious diarrhea and, in some cases, complications such as pseudomembrane formation, toxic megacolon (dilation of the colon) and peritonitis, which often lead to lethality among patients. The bacteria produce high molecular mass polypeptide cytotoxins, A and B. Some strains produce only one of the toxins, others produce both. Toxin A causes inflammatory reaction involving hypersecretion of fluid and hemorrhagic necrosis through triggering cytokine release by neutrophils. Alteration of intestinal microbial balance with antibiotic therapy and increased exposure to the bacterium in a hospital setting allows C. difficile to colonize susceptible individuals. Moreover, it has been shown that subinhibitory concentrations of antibiotics promote increased toxin production by C. difficile.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018867:10238:3252532525343211797Dehalobacter sp. CF chromosome, complete genomehypothetical protein5e-163575
NC_012781:700226:7119747119747136411668Eubacterium rectale ATCC 33656, complete genomeputative lipoprotein9e-67255
NC_012781:2552723:2585118258511825867851668Eubacterium rectale ATCC 33656, complete genomeputative lipoprotein9e-67255
NC_011837:238160:2502862502862522651980Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-55216
NC_009706:238160:2502862502862522651980Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-55216
NC_004668:2198027:2240101224010122428782778Enterococcus faecalis V583, complete genomepeptidase, M23/M37 family1e-45185
NC_016630:434500:4407164407164425571842Filifactor alocis ATCC 35896 chromosome, complete genomepeptidase, M23/M37 family5e-40166
NC_008023:1070986:1073455107345510752331779Streptococcus pyogenes MGAS2096, complete genomeantigen-like protein5e-40166
NC_015738:3042000:3061696306169630632731578Eggerthella sp. YY7918, complete genomehypothetical protein3e-39163
NC_012781:3315614:3322179332217933233691191Eubacterium rectale ATCC 33656, complete genomehypothetical protein2e-38160
NC_014624:224213:2265652265652284121848Eubacterium limosum KIST612 chromosome, complete genomeantigen-like protein5e-35149
NC_016630:1247251:1286269128626912885632295Filifactor alocis ATCC 35896 chromosome, complete genomeNlpC/P60 family protein2e-22107
NC_012471:1197534:1256412125641212587002289Streptococcus equi subsp. equi 4047, complete genomeconjugative transposon membrane protein2e-21104
NC_012471:719000:7310687310687331912124Streptococcus equi subsp. equi 4047, complete genomemembrane protein4e-1997.1
NC_012470:1390285:1431971143197114340942124Streptococcus equi subsp. zooepidemicus, complete genomemembrane protein2e-1895.1
NC_009089:478328:4894514894514915832133Clostridium difficile 630, complete genomehypothetical protein2e-1791.7
NC_009089:2150062:21362292136229218593049702Clostridium difficile 630, complete genome2e-1791.3
NC_013316:2033906:2091712209171220938442133Clostridium difficile R20291, complete genomehypothetical protein3e-1790.9
NC_013164:67500:7286272862754412580Anaerococcus prevotii DSM 20548 plasmid pAPRE01, complete sequenceNLP/P60 protein3e-1790.9
NC_012781:3315614:3346278334627833490792802Eubacterium rectale ATCC 33656, complete genomepeptidase, M23 family1e-1379
NC_015737:143428:1562601562601582091950Clostridium sp. SY8519, complete genomehypothetical protein5e-1376.6
NC_013510:2432879:2435585243558524366191035Thermomonospora curvata DSM 43183, complete genomeCHAP domain containing protein5e-1170.1
NC_014666:4118000:412803641280364128791756Frankia sp. EuI1c chromosome, complete genomePeptidoglycan-binding domain 1 protein1e-0758.5
NC_013510:39975:412074120742205999Thermomonospora curvata DSM 43183, complete genomePeptidoglycan-binding domain 1 protein3e-0653.9
NC_021184:4129419:413137641313764131858483Desulfotomaculum gibsoniae DSM 7213, complete genomeCHAP domain-containing protein5e-0653.5